Exercise Prevents Fatigue and Improves Quality of Life in Prostate Cancer Patients Undergoing Radiotherapy
Abstract Monga U, Garber SL, Thornby J, Vallbona C, Kerrigan AJ, Monga TN, Zimmermann KP. Exercise prevents fatigue and improves quality of life in prostate cancer patients undergoing radiotherapy. Objective To show fatigue prevention and quality of life (QOL) improvement from cardiovascular exercis...
Gespeichert in:
| Veröffentlicht in: | Archives of physical medicine and rehabilitation 2007-11, Vol.88 (11), p.1416-1422 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1422 |
|---|---|
| container_issue | 11 |
| container_start_page | 1416 |
| container_title | Archives of physical medicine and rehabilitation |
| container_volume | 88 |
| creator | Monga, Uma, MD Garber, Susan L., MA, OTR Thornby, John, PhD Vallbona, Carlos, MD Kerrigan, Anthony J., PhD Monga, Trilok N., MD Zimmermann, Kuno P., DO, PhD |
| description | Abstract Monga U, Garber SL, Thornby J, Vallbona C, Kerrigan AJ, Monga TN, Zimmermann KP. Exercise prevents fatigue and improves quality of life in prostate cancer patients undergoing radiotherapy. Objective To show fatigue prevention and quality of life (QOL) improvement from cardiovascular exercise during radiotherapy. Design Prospective enrollment (n=21), randomized to exercise (n=11) and control groups (n=10), with pre- and post-radiotherapy between- and within-group comparisons. Setting Academic medical center. Participants Localized prostate cancer patients undergoing radiotherapy. Interventions The interventional group received radiotherapy plus aerobic exercise 3 times a week for 8 weeks whereas the control group received radiotherapy without exercise. Main Outcome Measures Pre- and post-radiotherapy differences in cardiac fitness, fatigue, depression, functional status, physical, social, and functional well-being, leg strength, and flexibility were examined within and between 2 groups. Results No significant differences existed between 2 groups at pre-radiotherapy assessment. At post-radiotherapy assessment, the exercise group showed significant within group improvements in: cardiac fitness ( P |
| doi_str_mv | 10.1016/j.apmr.2007.08.110 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_771782311</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0003999307014487</els_id><sourcerecordid>771782311</sourcerecordid><originalsourceid>FETCH-LOGICAL-c471t-77de67bd14c04046100884954494212248e6461527de9ee2181d6b9d19bff02d3</originalsourceid><addsrcrecordid>eNp9kl-L1DAUxYso7uzqF_BB8qI-teamaZOALMiwqwsDrn8WfAuZ5HZM7bRj0g47397UGVjwYZ9Cwu_ce3POzbJXQAugUL9vC7PbhoJRKgoqCwD6JFtAVbJcMvj5NFtQSstcKVWeZecxtulaVyU8z85AqJpLCYusvbrHYH1Echtwj_0YybUZ_WZCYnpHbra7MOwxkq-T6fx4IENDVr5B4vskGOJoRiRL01sM5Dbp_hW46x2GzeD7DflmnB_GXxjM7vAie9aYLuLL03mR3V1f_Vh-zldfPt0sP65yywWMuRAOa7F2wC3llNdAqZRcVZwrzoAxLrFOrxVLnEJkIMHVa-VArZuGMldeZO-OddPofyaMo976aLHrTI_DFLUQICQrARL59lGylpzzqpQJZEfQpj_HgI3eBb814aCB6jkL3eo5Cz1noanUKYsken2qPq236B4kJ_MT8OYEmGhN14Tko48PnGKloKAS9-HIYXJt7zHoaJPTFp0PaEftBv_4HJf_yW3ne586_sYDxnaYQp_y0KAj01R_n7dmXhqamnMuRfkXhmS7yg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68444538</pqid></control><display><type>article</type><title>Exercise Prevents Fatigue and Improves Quality of Life in Prostate Cancer Patients Undergoing Radiotherapy</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Monga, Uma, MD ; Garber, Susan L., MA, OTR ; Thornby, John, PhD ; Vallbona, Carlos, MD ; Kerrigan, Anthony J., PhD ; Monga, Trilok N., MD ; Zimmermann, Kuno P., DO, PhD</creator><creatorcontrib>Monga, Uma, MD ; Garber, Susan L., MA, OTR ; Thornby, John, PhD ; Vallbona, Carlos, MD ; Kerrigan, Anthony J., PhD ; Monga, Trilok N., MD ; Zimmermann, Kuno P., DO, PhD</creatorcontrib><description>Abstract Monga U, Garber SL, Thornby J, Vallbona C, Kerrigan AJ, Monga TN, Zimmermann KP. Exercise prevents fatigue and improves quality of life in prostate cancer patients undergoing radiotherapy. Objective To show fatigue prevention and quality of life (QOL) improvement from cardiovascular exercise during radiotherapy. Design Prospective enrollment (n=21), randomized to exercise (n=11) and control groups (n=10), with pre- and post-radiotherapy between- and within-group comparisons. Setting Academic medical center. Participants Localized prostate cancer patients undergoing radiotherapy. Interventions The interventional group received radiotherapy plus aerobic exercise 3 times a week for 8 weeks whereas the control group received radiotherapy without exercise. Main Outcome Measures Pre- and post-radiotherapy differences in cardiac fitness, fatigue, depression, functional status, physical, social, and functional well-being, leg strength, and flexibility were examined within and between 2 groups. Results No significant differences existed between 2 groups at pre-radiotherapy assessment. At post-radiotherapy assessment, the exercise group showed significant within group improvements in: cardiac fitness ( P <.001), fatigue ( P =.02), Functional Assessment of Cancer Therapy–Prostate (FACT-P) ( P =.04), physical well-being ( P =.002), social well-being ( P =.02), flexibility ( P =.006), and leg strength ( P =.000). Within the control group, there was a significant increase in fatigue score ( P =.004) and a decline in social well-being ( P <.05) at post-radiotherapy assessment. Between-group differences at post-radiotherapy assessment were significant in cardiac fitness ( P =.006), strength ( P =.000), flexibility ( P <.01), fatigue ( P <.001), FACT-P ( P =.006), physical well-being ( P <.001), social well-being ( P =.002), and functional well-being ( P =.04). Conclusions An 8-week cardiovascular exercise program in patients with localized prostate cancer undergoing radiotherapy improved cardiovascular fitness, flexibility, muscle strength, and overall QOL and prevented fatigue.</description><identifier>ISSN: 0003-9993</identifier><identifier>EISSN: 1532-821X</identifier><identifier>DOI: 10.1016/j.apmr.2007.08.110</identifier><identifier>PMID: 17964881</identifier><identifier>CODEN: APMHAI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult and adolescent clinical studies ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Depression ; Exercise ; Exercise - psychology ; Exercise Test ; Fatigue - prevention & control ; Fatigue - psychology ; Gynecology. Andrology. Obstetrics ; Humans ; Male ; Male genital diseases ; Medical sciences ; Middle Aged ; Mood disorders ; Nephrology. Urinary tract diseases ; Physical Fitness - psychology ; Physical Medicine and Rehabilitation ; Pliability ; Prospective Studies ; Prostate cancer ; Prostatic Neoplasms - psychology ; Prostatic Neoplasms - radiotherapy ; Prostatic Neoplasms - rehabilitation ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Quality of life ; Quality of Life - psychology ; Rehabilitation ; Tumors ; Tumors of the urinary system ; Urinary tract. Prostate gland</subject><ispartof>Archives of physical medicine and rehabilitation, 2007-11, Vol.88 (11), p.1416-1422</ispartof><rights>American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation</rights><rights>2007 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-77de67bd14c04046100884954494212248e6461527de9ee2181d6b9d19bff02d3</citedby><cites>FETCH-LOGICAL-c471t-77de67bd14c04046100884954494212248e6461527de9ee2181d6b9d19bff02d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0003999307014487$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19237019$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17964881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Monga, Uma, MD</creatorcontrib><creatorcontrib>Garber, Susan L., MA, OTR</creatorcontrib><creatorcontrib>Thornby, John, PhD</creatorcontrib><creatorcontrib>Vallbona, Carlos, MD</creatorcontrib><creatorcontrib>Kerrigan, Anthony J., PhD</creatorcontrib><creatorcontrib>Monga, Trilok N., MD</creatorcontrib><creatorcontrib>Zimmermann, Kuno P., DO, PhD</creatorcontrib><title>Exercise Prevents Fatigue and Improves Quality of Life in Prostate Cancer Patients Undergoing Radiotherapy</title><title>Archives of physical medicine and rehabilitation</title><addtitle>Arch Phys Med Rehabil</addtitle><description>Abstract Monga U, Garber SL, Thornby J, Vallbona C, Kerrigan AJ, Monga TN, Zimmermann KP. Exercise prevents fatigue and improves quality of life in prostate cancer patients undergoing radiotherapy. Objective To show fatigue prevention and quality of life (QOL) improvement from cardiovascular exercise during radiotherapy. Design Prospective enrollment (n=21), randomized to exercise (n=11) and control groups (n=10), with pre- and post-radiotherapy between- and within-group comparisons. Setting Academic medical center. Participants Localized prostate cancer patients undergoing radiotherapy. Interventions The interventional group received radiotherapy plus aerobic exercise 3 times a week for 8 weeks whereas the control group received radiotherapy without exercise. Main Outcome Measures Pre- and post-radiotherapy differences in cardiac fitness, fatigue, depression, functional status, physical, social, and functional well-being, leg strength, and flexibility were examined within and between 2 groups. Results No significant differences existed between 2 groups at pre-radiotherapy assessment. At post-radiotherapy assessment, the exercise group showed significant within group improvements in: cardiac fitness ( P <.001), fatigue ( P =.02), Functional Assessment of Cancer Therapy–Prostate (FACT-P) ( P =.04), physical well-being ( P =.002), social well-being ( P =.02), flexibility ( P =.006), and leg strength ( P =.000). Within the control group, there was a significant increase in fatigue score ( P =.004) and a decline in social well-being ( P <.05) at post-radiotherapy assessment. Between-group differences at post-radiotherapy assessment were significant in cardiac fitness ( P =.006), strength ( P =.000), flexibility ( P <.01), fatigue ( P <.001), FACT-P ( P =.006), physical well-being ( P <.001), social well-being ( P =.002), and functional well-being ( P =.04). Conclusions An 8-week cardiovascular exercise program in patients with localized prostate cancer undergoing radiotherapy improved cardiovascular fitness, flexibility, muscle strength, and overall QOL and prevented fatigue.</description><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Depression</subject><subject>Exercise</subject><subject>Exercise - psychology</subject><subject>Exercise Test</subject><subject>Fatigue - prevention & control</subject><subject>Fatigue - psychology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Physical Fitness - psychology</subject><subject>Physical Medicine and Rehabilitation</subject><subject>Pliability</subject><subject>Prospective Studies</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - psychology</subject><subject>Prostatic Neoplasms - radiotherapy</subject><subject>Prostatic Neoplasms - rehabilitation</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Quality of life</subject><subject>Quality of Life - psychology</subject><subject>Rehabilitation</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. Prostate gland</subject><issn>0003-9993</issn><issn>1532-821X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kl-L1DAUxYso7uzqF_BB8qI-teamaZOALMiwqwsDrn8WfAuZ5HZM7bRj0g47397UGVjwYZ9Cwu_ce3POzbJXQAugUL9vC7PbhoJRKgoqCwD6JFtAVbJcMvj5NFtQSstcKVWeZecxtulaVyU8z85AqJpLCYusvbrHYH1Echtwj_0YybUZ_WZCYnpHbra7MOwxkq-T6fx4IENDVr5B4vskGOJoRiRL01sM5Dbp_hW46x2GzeD7DflmnB_GXxjM7vAie9aYLuLL03mR3V1f_Vh-zldfPt0sP65yywWMuRAOa7F2wC3llNdAqZRcVZwrzoAxLrFOrxVLnEJkIMHVa-VArZuGMldeZO-OddPofyaMo976aLHrTI_DFLUQICQrARL59lGylpzzqpQJZEfQpj_HgI3eBb814aCB6jkL3eo5Cz1noanUKYsken2qPq236B4kJ_MT8OYEmGhN14Tko48PnGKloKAS9-HIYXJt7zHoaJPTFp0PaEftBv_4HJf_yW3ne586_sYDxnaYQp_y0KAj01R_n7dmXhqamnMuRfkXhmS7yg</recordid><startdate>20071101</startdate><enddate>20071101</enddate><creator>Monga, Uma, MD</creator><creator>Garber, Susan L., MA, OTR</creator><creator>Thornby, John, PhD</creator><creator>Vallbona, Carlos, MD</creator><creator>Kerrigan, Anthony J., PhD</creator><creator>Monga, Trilok N., MD</creator><creator>Zimmermann, Kuno P., DO, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071101</creationdate><title>Exercise Prevents Fatigue and Improves Quality of Life in Prostate Cancer Patients Undergoing Radiotherapy</title><author>Monga, Uma, MD ; Garber, Susan L., MA, OTR ; Thornby, John, PhD ; Vallbona, Carlos, MD ; Kerrigan, Anthony J., PhD ; Monga, Trilok N., MD ; Zimmermann, Kuno P., DO, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-77de67bd14c04046100884954494212248e6461527de9ee2181d6b9d19bff02d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Depression</topic><topic>Exercise</topic><topic>Exercise - psychology</topic><topic>Exercise Test</topic><topic>Fatigue - prevention & control</topic><topic>Fatigue - psychology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Physical Fitness - psychology</topic><topic>Physical Medicine and Rehabilitation</topic><topic>Pliability</topic><topic>Prospective Studies</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - psychology</topic><topic>Prostatic Neoplasms - radiotherapy</topic><topic>Prostatic Neoplasms - rehabilitation</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Quality of life</topic><topic>Quality of Life - psychology</topic><topic>Rehabilitation</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Monga, Uma, MD</creatorcontrib><creatorcontrib>Garber, Susan L., MA, OTR</creatorcontrib><creatorcontrib>Thornby, John, PhD</creatorcontrib><creatorcontrib>Vallbona, Carlos, MD</creatorcontrib><creatorcontrib>Kerrigan, Anthony J., PhD</creatorcontrib><creatorcontrib>Monga, Trilok N., MD</creatorcontrib><creatorcontrib>Zimmermann, Kuno P., DO, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of physical medicine and rehabilitation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Monga, Uma, MD</au><au>Garber, Susan L., MA, OTR</au><au>Thornby, John, PhD</au><au>Vallbona, Carlos, MD</au><au>Kerrigan, Anthony J., PhD</au><au>Monga, Trilok N., MD</au><au>Zimmermann, Kuno P., DO, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise Prevents Fatigue and Improves Quality of Life in Prostate Cancer Patients Undergoing Radiotherapy</atitle><jtitle>Archives of physical medicine and rehabilitation</jtitle><addtitle>Arch Phys Med Rehabil</addtitle><date>2007-11-01</date><risdate>2007</risdate><volume>88</volume><issue>11</issue><spage>1416</spage><epage>1422</epage><pages>1416-1422</pages><issn>0003-9993</issn><eissn>1532-821X</eissn><coden>APMHAI</coden><abstract>Abstract Monga U, Garber SL, Thornby J, Vallbona C, Kerrigan AJ, Monga TN, Zimmermann KP. Exercise prevents fatigue and improves quality of life in prostate cancer patients undergoing radiotherapy. Objective To show fatigue prevention and quality of life (QOL) improvement from cardiovascular exercise during radiotherapy. Design Prospective enrollment (n=21), randomized to exercise (n=11) and control groups (n=10), with pre- and post-radiotherapy between- and within-group comparisons. Setting Academic medical center. Participants Localized prostate cancer patients undergoing radiotherapy. Interventions The interventional group received radiotherapy plus aerobic exercise 3 times a week for 8 weeks whereas the control group received radiotherapy without exercise. Main Outcome Measures Pre- and post-radiotherapy differences in cardiac fitness, fatigue, depression, functional status, physical, social, and functional well-being, leg strength, and flexibility were examined within and between 2 groups. Results No significant differences existed between 2 groups at pre-radiotherapy assessment. At post-radiotherapy assessment, the exercise group showed significant within group improvements in: cardiac fitness ( P <.001), fatigue ( P =.02), Functional Assessment of Cancer Therapy–Prostate (FACT-P) ( P =.04), physical well-being ( P =.002), social well-being ( P =.02), flexibility ( P =.006), and leg strength ( P =.000). Within the control group, there was a significant increase in fatigue score ( P =.004) and a decline in social well-being ( P <.05) at post-radiotherapy assessment. Between-group differences at post-radiotherapy assessment were significant in cardiac fitness ( P =.006), strength ( P =.000), flexibility ( P <.01), fatigue ( P <.001), FACT-P ( P =.006), physical well-being ( P <.001), social well-being ( P =.002), and functional well-being ( P =.04). Conclusions An 8-week cardiovascular exercise program in patients with localized prostate cancer undergoing radiotherapy improved cardiovascular fitness, flexibility, muscle strength, and overall QOL and prevented fatigue.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17964881</pmid><doi>10.1016/j.apmr.2007.08.110</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-9993 |
| ispartof | Archives of physical medicine and rehabilitation, 2007-11, Vol.88 (11), p.1416-1422 |
| issn | 0003-9993 1532-821X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_771782311 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult and adolescent clinical studies Aged Aged, 80 and over Biological and medical sciences Depression Exercise Exercise - psychology Exercise Test Fatigue - prevention & control Fatigue - psychology Gynecology. Andrology. Obstetrics Humans Male Male genital diseases Medical sciences Middle Aged Mood disorders Nephrology. Urinary tract diseases Physical Fitness - psychology Physical Medicine and Rehabilitation Pliability Prospective Studies Prostate cancer Prostatic Neoplasms - psychology Prostatic Neoplasms - radiotherapy Prostatic Neoplasms - rehabilitation Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Quality of life Quality of Life - psychology Rehabilitation Tumors Tumors of the urinary system Urinary tract. Prostate gland |
| title | Exercise Prevents Fatigue and Improves Quality of Life in Prostate Cancer Patients Undergoing Radiotherapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-18T22%3A47%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Exercise%20Prevents%20Fatigue%20and%20Improves%20Quality%20of%20Life%20in%20Prostate%20Cancer%20Patients%20Undergoing%20Radiotherapy&rft.jtitle=Archives%20of%20physical%20medicine%20and%20rehabilitation&rft.au=Monga,%20Uma,%20MD&rft.date=2007-11-01&rft.volume=88&rft.issue=11&rft.spage=1416&rft.epage=1422&rft.pages=1416-1422&rft.issn=0003-9993&rft.eissn=1532-821X&rft.coden=APMHAI&rft_id=info:doi/10.1016/j.apmr.2007.08.110&rft_dat=%3Cproquest_cross%3E771782311%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68444538&rft_id=info:pmid/17964881&rft_els_id=1_s2_0_S0003999307014487&rfr_iscdi=true |