An automated and fully validated LC-MS/MS procedure for the simultaneous determination of 11 opioids used in palliative care, with 5 of their metabolites

A fully validated liquid chromatographic procedure coupled with electrospray ionization–tandem mass spectrometry (LC‐ESI‐MS/MS) is presented for quantitative determination of the opioids buprenorphine, codeine, fentanyl, hydromorphone, methadone, morphine, oxycodone, oxymorphone, piritramide, tilidi...

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Veröffentlicht in:	Journal of mass spectrometry. 2006-05, Vol.41 (5), p.633-640
Hauptverfasser:	Musshoff, F., Trafkowski, J., Kuepper, U., Madea, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - analysis Analgesics, Opioid - blood Analgesics, Opioid - pharmacokinetics Analysis Biological and medical sciences blood plasma Chromatography, Liquid - methods Chromatography, Liquid - standards drug monitoring Fentanyl - analogs & derivatives Fentanyl - analysis Fentanyl - blood General pharmacology Humans LC-MS/MS Medical sciences Morphine Derivatives - analysis Morphine Derivatives - blood opioids Palliative Care Patient Compliance Pharmacology. Drug treatments solid-phase extraction Spectrometry, Mass, Electrospray Ionization - methods Spectrometry, Mass, Electrospray Ionization - standards Tilidine - analogs & derivatives Tilidine - analysis Tilidine - blood
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