Induction of apoptosis in human acute leukemia Jurkat T cells by Albizzia julibrissin extract is mediated via mitochondria-dependent caspase-3 activation

To understand antitumor activity of Albizzia julibrissin Durazz (Leguminosae), which has been used as a traditional oriental medicine, the mechanism underlying cytotoxic effect of its extract on human acute leukemia Jurkat T cells were investigated. The methanol extract of the stripped barks (3 kg)...

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Veröffentlicht in:	Journal of ethnopharmacology 2006-07, Vol.106 (3), p.383-389
Hauptverfasser:	Won, Hae Jeung, Han, Chang Hee, Kim, Young Ho, Kwon, Hyun Ju, Kim, Byung Woo, Choi, Jae Soo, Kim, Kwang-Hyeon
Format:	Artikel
Sprache:	eng
Schlagworte:	Albizia julibrissin Albizzia Albizzia julibrissin Anticancer antineoplastic agents Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Apoptosis Apoptosis - drug effects bark Biological and medical sciences Caspase 3 Caspases - biosynthesis Cell Cycle - drug effects chemical constituents of plants Cytotoxicity Dose-Response Relationship, Drug ethnobotany Flow Cytometry General pharmacology herbal medicines human cell lines Humans In Situ Nick-End Labeling Jurkat Cells - drug effects Jurkat T cell leukemia Leukemia - drug therapy Leukocytes, Mononuclear - drug effects Medical sciences medicinal plants medicinal properties mitochondria Mitochondria - drug effects Mitochondria - metabolism Oriental traditional medicine Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use signal transduction
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