Spironolactone-reversible rickets associated with 11 β-hydroxysteroid dehydrogenase deficiency syndrome

A 7-year-old girl had growth retardation, hypertension, and hypokalemic alkalosis. Baseline serum aldosterone concentration and plasma renin activity were low and unresponsive to sodium deprivation and to orthostatic changes. Baseline serum progesterone, 17-hydroxyprogesterone, 11-deoxycortisol, and...

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Veröffentlicht in:	The Journal of pediatrics 1986-12, Vol.109 (6), p.989-993
Hauptverfasser:	Batista, Marcelo C., Mendonça, Berenice B., Kater, Cláudio E., Arnhold, Ivo J.P., Rocha, Antonino, Nicolau, Wilian, Bloise, Walter
Format:	Artikel
Sprache:	eng
Schlagworte:	11-beta-Hydroxysteroid Dehydrogenases Adrenocorticotropic Hormone - pharmacology Aldosterone - blood Alkalosis - complications Biological and medical sciences Bone and Bones - metabolism Child Female Hormones. Endocrine system Humans Hydroxysteroid Dehydrogenases - deficiency Hypertension - complications Hypokalemia - complications Medical sciences Minerals - metabolism Parathyroid Glands - physiopathology Pharmacology. Drug treatments Posture Renin - blood Rickets - complications Rickets - drug therapy Sodium - administration & dosage Spironolactone - administration & dosage Spironolactone - therapeutic use Steroids - urine Syndrome Triamterene - administration & dosage
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