Use of a Specific and Sensitive Assay to Determine Pentamidine Pharmacokinetics in Patients with AIDS

The first-dose pharmacokinetics of pentamidine were studied in patients with AIDS. Pentamidine isethionate (4 mg/kg) was administered intramuscularly or intravenously to two groups of six patients each. Serial plasma and urine concentrations were measured by high-performance liquid chromatography, w...

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Veröffentlicht in:	The Journal of infectious diseases 1986-12, Vol.154 (6), p.923-929
Hauptverfasser:	Conte, John E., Upton, Robert A., Phelps, Roger T., Wofsy, Constance B., Zurlinden, Elisabeth, Lin, Emil T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - metabolism Adult AIDS/HIV Amidines - metabolism Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Blood plasma Chromatography, High Pressure Liquid Creatinine - blood Dosage Excretion Half lives Health care administration Homosexuality Humans Infectious diseases Injections, Intramuscular Injections, Intravenous Internships Male Medical sciences Middle Aged Pentamidine - blood Pentamidine - metabolism Pentamidine - urine Pharmacokinetics Pharmacology. Drug treatments Pneumonia, Pneumocystis - metabolism Renal clearance Urine
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