PROPIOXATINS A AND B, NEW ENKEPHALINASE B INHIBITORS: I. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIES
A soil isolate of actinomycete, strain SANK 60684, was found to produce new enkephalinase B inhibitors, propioxatins A and B. The presence of both LL- and meso-2, 6-diaminopimelic acid, glycine and galactose in the cell wall assigned this strain to genus Kitasatosporia. From the morphological, cultu...
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| Veröffentlicht in: | Journal of antibiotics 1986, Vol.39(10), pp.1368-1377 |
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| container_issue | 10 |
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| container_title | Journal of antibiotics |
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| creator | INAOKA, YOSHINORI TAMAOKI, HIDETSUNE TAKAHASHI, SHUJI ENOKITA, RYUZO OKAZAKI, TAKAO |
| description | A soil isolate of actinomycete, strain SANK 60684, was found to produce new enkephalinase B inhibitors, propioxatins A and B. The presence of both LL- and meso-2, 6-diaminopimelic acid, glycine and galactose in the cell wall assigned this strain to genus Kitasatosporia. From the morphological, cultural and physiological characteristics, this strain was determined to be Kitasatosporia setae. The Ki values of propioxatins A and B were 1.3×10-8 M and 1.1×10-7 M, respectively, for enkephalinase B. All other proteases examined except aminopeptidases, which were slightly inhibited, were not inhibited by these two compounds. |
| doi_str_mv | 10.7164/antibiotics.39.1368 |
| format | Article |
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TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIES</title><source>J-STAGE Free</source><source>MEDLINE</source><creator>INAOKA, YOSHINORI ; TAMAOKI, HIDETSUNE ; TAKAHASHI, SHUJI ; ENOKITA, RYUZO ; OKAZAKI, TAKAO</creator><creatorcontrib>INAOKA, YOSHINORI ; TAMAOKI, HIDETSUNE ; TAKAHASHI, SHUJI ; ENOKITA, RYUZO ; OKAZAKI, TAKAO</creatorcontrib><description>A soil isolate of actinomycete, strain SANK 60684, was found to produce new enkephalinase B inhibitors, propioxatins A and B. The presence of both LL- and meso-2, 6-diaminopimelic acid, glycine and galactose in the cell wall assigned this strain to genus Kitasatosporia. From the morphological, cultural and physiological characteristics, this strain was determined to be Kitasatosporia setae. The Ki values of propioxatins A and B were 1.3×10-8 M and 1.1×10-7 M, respectively, for enkephalinase B. All other proteases examined except aminopeptidases, which were slightly inhibited, were not inhibited by these two compounds.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.39.1368</identifier><identifier>PMID: 3536826</identifier><language>eng</language><publisher>Japan: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Actinomycetales - metabolism ; Animals ; Brain - enzymology ; Chromatography, High Pressure Liquid ; Dipeptides - isolation & purification ; Dipeptides - pharmacology ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - antagonists & inhibitors ; Endopeptidases - metabolism ; Enkephalins - metabolism ; Fermentation ; Magnetic Resonance Spectroscopy ; Male ; Protease Inhibitors - isolation & purification ; Protease Inhibitors - pharmacology ; Rats ; Rats, Inbred Strains ; Spectrophotometry, Infrared</subject><ispartof>The Journal of Antibiotics, 1986, Vol.39(10), pp.1368-1377</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4338-ce2750914f2f97b1a4f10a2c4863375819e2fd0137bc5e1e4364bd519d1ac0303</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3536826$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>INAOKA, YOSHINORI</creatorcontrib><creatorcontrib>TAMAOKI, HIDETSUNE</creatorcontrib><creatorcontrib>TAKAHASHI, SHUJI</creatorcontrib><creatorcontrib>ENOKITA, RYUZO</creatorcontrib><creatorcontrib>OKAZAKI, TAKAO</creatorcontrib><title>PROPIOXATINS A AND B, NEW ENKEPHALINASE B INHIBITORS: I. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIES</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>A soil isolate of actinomycete, strain SANK 60684, was found to produce new enkephalinase B inhibitors, propioxatins A and B. The presence of both LL- and meso-2, 6-diaminopimelic acid, glycine and galactose in the cell wall assigned this strain to genus Kitasatosporia. From the morphological, cultural and physiological characteristics, this strain was determined to be Kitasatosporia setae. The Ki values of propioxatins A and B were 1.3×10-8 M and 1.1×10-7 M, respectively, for enkephalinase B. All other proteases examined except aminopeptidases, which were slightly inhibited, were not inhibited by these two compounds.</description><subject>Actinomycetales - metabolism</subject><subject>Animals</subject><subject>Brain - enzymology</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Dipeptides - isolation & purification</subject><subject>Dipeptides - pharmacology</subject><subject>Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - antagonists & inhibitors</subject><subject>Endopeptidases - metabolism</subject><subject>Enkephalins - metabolism</subject><subject>Fermentation</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Protease Inhibitors - isolation & purification</subject><subject>Protease Inhibitors - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Spectrophotometry, Infrared</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkEFPwkAQhTdGg4j-AmPSkyeLO91td_dYsEojaQlg9LbZLlutKRS75eC_t0hDuMwc3nvfZB5Ct4CHDAL6qDZNkRVVU2g7JGIIJOBnqA-cgws0EOeoj7EHLucevkRX1n5jTBhhvId6xG_NXtBHdDZPZ3H6ES7jZOGETpg8OaMHJ4nenSh5jWaTcBon4SJyRk6cTOJRvEzni2t0kavSmptuD9Dbc7QcT9xp-hKPw6mrKSHc1cZjPhZAcy8XLANFc8DK05QHhDCfgzBevsJAWKZ9A4aSgGYrH8QKlMYEkwG6P3C3dfWzM7aR68JqU5ZqY6qdlYwBa1_krZEcjLqurK1NLrd1sVb1rwQs913Jk64kEXLfVZu66_C7bG1Wx0xXTqsnB_3bNurTHHVVt5jSnDJBBPyfi7u5P3A06i9VS7Mhf9rPfU0</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>INAOKA, YOSHINORI</creator><creator>TAMAOKI, HIDETSUNE</creator><creator>TAKAHASHI, SHUJI</creator><creator>ENOKITA, RYUZO</creator><creator>OKAZAKI, TAKAO</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1986</creationdate><title>PROPIOXATINS A AND B, NEW ENKEPHALINASE B INHIBITORS</title><author>INAOKA, YOSHINORI ; TAMAOKI, HIDETSUNE ; TAKAHASHI, SHUJI ; ENOKITA, RYUZO ; OKAZAKI, TAKAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4338-ce2750914f2f97b1a4f10a2c4863375819e2fd0137bc5e1e4364bd519d1ac0303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Actinomycetales - metabolism</topic><topic>Animals</topic><topic>Brain - enzymology</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Dipeptides - isolation & purification</topic><topic>Dipeptides - pharmacology</topic><topic>Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - antagonists & inhibitors</topic><topic>Endopeptidases - metabolism</topic><topic>Enkephalins - metabolism</topic><topic>Fermentation</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Protease Inhibitors - isolation & purification</topic><topic>Protease Inhibitors - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Spectrophotometry, Infrared</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>INAOKA, YOSHINORI</creatorcontrib><creatorcontrib>TAMAOKI, HIDETSUNE</creatorcontrib><creatorcontrib>TAKAHASHI, SHUJI</creatorcontrib><creatorcontrib>ENOKITA, RYUZO</creatorcontrib><creatorcontrib>OKAZAKI, TAKAO</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>INAOKA, YOSHINORI</au><au>TAMAOKI, HIDETSUNE</au><au>TAKAHASHI, SHUJI</au><au>ENOKITA, RYUZO</au><au>OKAZAKI, TAKAO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PROPIOXATINS A AND B, NEW ENKEPHALINASE B INHIBITORS: I. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIES</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1986</date><risdate>1986</risdate><volume>39</volume><issue>10</issue><spage>1368</spage><epage>1377</epage><pages>1368-1377</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>A soil isolate of actinomycete, strain SANK 60684, was found to produce new enkephalinase B inhibitors, propioxatins A and B. The presence of both LL- and meso-2, 6-diaminopimelic acid, glycine and galactose in the cell wall assigned this strain to genus Kitasatosporia. From the morphological, cultural and physiological characteristics, this strain was determined to be Kitasatosporia setae. The Ki values of propioxatins A and B were 1.3×10-8 M and 1.1×10-7 M, respectively, for enkephalinase B. All other proteases examined except aminopeptidases, which were slightly inhibited, were not inhibited by these two compounds.</abstract><cop>Japan</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>3536826</pmid><doi>10.7164/antibiotics.39.1368</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1986, Vol.39(10), pp.1368-1377 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77170028 |
| source | J-STAGE Free; MEDLINE |
| subjects | Actinomycetales - metabolism Animals Brain - enzymology Chromatography, High Pressure Liquid Dipeptides - isolation & purification Dipeptides - pharmacology Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - antagonists & inhibitors Endopeptidases - metabolism Enkephalins - metabolism Fermentation Magnetic Resonance Spectroscopy Male Protease Inhibitors - isolation & purification Protease Inhibitors - pharmacology Rats Rats, Inbred Strains Spectrophotometry, Infrared |
| title | PROPIOXATINS A AND B, NEW ENKEPHALINASE B INHIBITORS: I. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIES |
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