Evaluation of the antimicrobial effects of several isothiocyanates on Helicobacter pylori
Abstract The antibacterial activity of sulforaphane [4-(methylsulfinyl)butyl isothiocyanate] has been previously described. We have analysed the activities of 12 isothiocyanates (ITC) including sulphoraphane on 25 strains of HELICOBACTER PYLORI using an agar dilution assay. In addition, bactericidal...
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| Veröffentlicht in: | Planta medica 2005-04, Vol.71 (4), p.326-330 |
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| creator | Haristoy, X Fahey, J.W Scholtus, I Lozniewski, A |
| description | Abstract
The antibacterial activity of sulforaphane [4-(methylsulfinyl)butyl isothiocyanate] has been previously described. We have analysed the activities of 12 isothiocyanates (ITC) including sulphoraphane on 25 strains of HELICOBACTER PYLORI using an agar dilution assay. In addition, bactericidal effects against H. PYLORI were determined for the 6 most active ITCs, both directly and against intracellular bacteria in cultured human epithelial (HEp-2) cells. The MIC
90
values for these ITCs ranged between 4 and 32 μg/mL and four of the most potent compounds exhibited bactericidal activity against both extra- and intracellular bacteria. Overall, our data indicate that ITCs have a potent antibacterial effect against H. PYLORI and these naturally occurring phytochemicals might have potential as novel therapeutic agents for H. PYLORI eradication. |
| doi_str_mv | 10.1055/s-2005-864098 |
| format | Article |
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The antibacterial activity of sulforaphane [4-(methylsulfinyl)butyl isothiocyanate] has been previously described. We have analysed the activities of 12 isothiocyanates (ITC) including sulphoraphane on 25 strains of HELICOBACTER PYLORI using an agar dilution assay. In addition, bactericidal effects against H. PYLORI were determined for the 6 most active ITCs, both directly and against intracellular bacteria in cultured human epithelial (HEp-2) cells. The MIC
90
values for these ITCs ranged between 4 and 32 μg/mL and four of the most potent compounds exhibited bactericidal activity against both extra- and intracellular bacteria. Overall, our data indicate that ITCs have a potent antibacterial effect against H. PYLORI and these naturally occurring phytochemicals might have potential as novel therapeutic agents for H. PYLORI eradication.</description><identifier>ISSN: 0032-0943</identifier><identifier>EISSN: 1439-0221</identifier><identifier>DOI: 10.1055/s-2005-864098</identifier><identifier>PMID: 15856408</identifier><identifier>CODEN: PLMEAA</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; antibacterial properties ; Biological and medical sciences ; Brassicaceae ; cultured cells ; General pharmacology ; Helicobacter Infections - drug therapy ; Helicobacter pylori ; Helicobacter pylori - drug effects ; Humans ; isothiocyanates ; Isothiocyanates - administration & dosage ; Isothiocyanates - pharmacology ; Isothiocyanates - therapeutic use ; Medical sciences ; Microbial Sensitivity Tests ; Moringa oleifera ; Original Paper ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; phytochemicals ; Phytotherapy ; Plants, Medicinal ; sulforaphane</subject><ispartof>Planta medica, 2005-04, Vol.71 (4), p.326-330</ispartof><rights>Georg Thieme Verlag KG Stuttgart · New York</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c376t-d0b885d41603236a5a2e96dfd9be90df264f0a44ee516c918acc35126e3da7433</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2005-864098.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2005-864098$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,776,780,3005,27901,27902,54534,54535</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16737599$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15856408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haristoy, X</creatorcontrib><creatorcontrib>Fahey, J.W</creatorcontrib><creatorcontrib>Scholtus, I</creatorcontrib><creatorcontrib>Lozniewski, A</creatorcontrib><title>Evaluation of the antimicrobial effects of several isothiocyanates on Helicobacter pylori</title><title>Planta medica</title><addtitle>Planta Med</addtitle><description>Abstract
The antibacterial activity of sulforaphane [4-(methylsulfinyl)butyl isothiocyanate] has been previously described. We have analysed the activities of 12 isothiocyanates (ITC) including sulphoraphane on 25 strains of HELICOBACTER PYLORI using an agar dilution assay. In addition, bactericidal effects against H. PYLORI were determined for the 6 most active ITCs, both directly and against intracellular bacteria in cultured human epithelial (HEp-2) cells. The MIC
90
values for these ITCs ranged between 4 and 32 μg/mL and four of the most potent compounds exhibited bactericidal activity against both extra- and intracellular bacteria. Overall, our data indicate that ITCs have a potent antibacterial effect against H. PYLORI and these naturally occurring phytochemicals might have potential as novel therapeutic agents for H. PYLORI eradication.</description><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>antibacterial properties</subject><subject>Biological and medical sciences</subject><subject>Brassicaceae</subject><subject>cultured cells</subject><subject>General pharmacology</subject><subject>Helicobacter Infections - drug therapy</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - drug effects</subject><subject>Humans</subject><subject>isothiocyanates</subject><subject>Isothiocyanates - administration & dosage</subject><subject>Isothiocyanates - pharmacology</subject><subject>Isothiocyanates - therapeutic use</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Moringa oleifera</subject><subject>Original Paper</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>phytochemicals</subject><subject>Phytotherapy</subject><subject>Plants, Medicinal</subject><subject>sulforaphane</subject><issn>0032-0943</issn><issn>1439-0221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90U1v1DAQBmALgei2cOQKuVAuBMbxV3xEVUuRKvVQeuBkTZwJdZXEi51U2n9fr3YRN06WPI9H1vsy9o7DFw5Kfc11A6DqVkuw7Qu24VLYGpqGv2QbANHUYKU4Yac5PwJwaQFesxOuWlUetBv26_IJxxWXEOcqDtXyQBXOS5iCT7ELOFY0DOSXvB9meqJUrkKOy0OIfoczLlRGc3VNY_CxQ79Qqra7Mabwhr0acMz09niesfury58X1_XN7fcfF99uai-MXuoeurZVveS6fFZoVNiQ1f3Q244s9EOj5QAoJZHi2lveovdC8UaT6NFIIc7Yp8PebYp_VsqLm0L2NI44U1yzM4br1kplijz_r9TGtFqALvD9Ea7dRL3bpjBh2rm_sRXw8QgwexyHhLMP-Z_TRhhlbXGfD67kRRO5x7imuYThOLh9ey67fXvu0F7hHw58wOjwdyor7-8a4AI4gJFgxDPZYJL9</recordid><startdate>20050401</startdate><enddate>20050401</enddate><creator>Haristoy, X</creator><creator>Fahey, J.W</creator><creator>Scholtus, I</creator><creator>Lozniewski, A</creator><general>Thieme</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20050401</creationdate><title>Evaluation of the antimicrobial effects of several isothiocyanates on Helicobacter pylori</title><author>Haristoy, X ; Fahey, J.W ; Scholtus, I ; Lozniewski, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c376t-d0b885d41603236a5a2e96dfd9be90df264f0a44ee516c918acc35126e3da7433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>antibacterial properties</topic><topic>Biological and medical sciences</topic><topic>Brassicaceae</topic><topic>cultured cells</topic><topic>General pharmacology</topic><topic>Helicobacter Infections - drug therapy</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - drug effects</topic><topic>Humans</topic><topic>isothiocyanates</topic><topic>Isothiocyanates - administration & dosage</topic><topic>Isothiocyanates - pharmacology</topic><topic>Isothiocyanates - therapeutic use</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Moringa oleifera</topic><topic>Original Paper</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>phytochemicals</topic><topic>Phytotherapy</topic><topic>Plants, Medicinal</topic><topic>sulforaphane</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haristoy, X</creatorcontrib><creatorcontrib>Fahey, J.W</creatorcontrib><creatorcontrib>Scholtus, I</creatorcontrib><creatorcontrib>Lozniewski, A</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Planta medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haristoy, X</au><au>Fahey, J.W</au><au>Scholtus, I</au><au>Lozniewski, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the antimicrobial effects of several isothiocyanates on Helicobacter pylori</atitle><jtitle>Planta medica</jtitle><addtitle>Planta Med</addtitle><date>2005-04-01</date><risdate>2005</risdate><volume>71</volume><issue>4</issue><spage>326</spage><epage>330</epage><pages>326-330</pages><issn>0032-0943</issn><eissn>1439-0221</eissn><coden>PLMEAA</coden><abstract>Abstract
The antibacterial activity of sulforaphane [4-(methylsulfinyl)butyl isothiocyanate] has been previously described. We have analysed the activities of 12 isothiocyanates (ITC) including sulphoraphane on 25 strains of HELICOBACTER PYLORI using an agar dilution assay. In addition, bactericidal effects against H. PYLORI were determined for the 6 most active ITCs, both directly and against intracellular bacteria in cultured human epithelial (HEp-2) cells. The MIC
90
values for these ITCs ranged between 4 and 32 μg/mL and four of the most potent compounds exhibited bactericidal activity against both extra- and intracellular bacteria. Overall, our data indicate that ITCs have a potent antibacterial effect against H. PYLORI and these naturally occurring phytochemicals might have potential as novel therapeutic agents for H. PYLORI eradication.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>15856408</pmid><doi>10.1055/s-2005-864098</doi><tpages>5</tpages></addata></record> |
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| subjects | Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use antibacterial properties Biological and medical sciences Brassicaceae cultured cells General pharmacology Helicobacter Infections - drug therapy Helicobacter pylori Helicobacter pylori - drug effects Humans isothiocyanates Isothiocyanates - administration & dosage Isothiocyanates - pharmacology Isothiocyanates - therapeutic use Medical sciences Microbial Sensitivity Tests Moringa oleifera Original Paper Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytochemicals Phytotherapy Plants, Medicinal sulforaphane |
| title | Evaluation of the antimicrobial effects of several isothiocyanates on Helicobacter pylori |
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