Anaplastic carcinoma of the thyroid: A 24-year experience
Background. Anaplastic carcinoma of the thyroid gland is a lethal entity; few patients live more than 12 months following diagnosis. We retrospectively reviewed the experience with this entity at our cancer institute and identified a subgroup of patients with complete resection who have a 60% 5‐year...
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| Veröffentlicht in: | Head & neck 1995-01, Vol.17 (1), p.41-48 |
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| creator | Tan, Raymond K. Finley III, Robert K. Driscoll, Deborah Bakamjian, Vahram Hicks Jr, Wesley L. Shedd, Donald P. |
| description | Background. Anaplastic carcinoma of the thyroid gland is a lethal entity; few patients live more than 12 months following diagnosis. We retrospectively reviewed the experience with this entity at our cancer institute and identified a subgroup of patients with complete resection who have a 60% 5‐year survival.
Methods. Twenty‐one cases of anaplastic carcinoma of the thyroid gland were analyzed retorspectively with respect to prognostic factors influencing survival. This represents 2.7% of 771 cases of thyroid cancer seen at our institution from 1968 to 1992. The median age at presentation was 65.1 years; male/female ratio was 1:1.1; and the most common symptom was a rapidly enlarging neck mass (76%).
Results. Estimated 5‐year survival was 10% (median: 4.5 months). Tumor size less than 6.0 cm (p = .004) and female gender (p = .02) were significant prognostic factors. Five patients who underwent complete resection had an estimated 5‐year survival of 60% (median: 131 months). Four of these patients had postoperative radiotherapy with or without sequential chemotherapy. Two of these patients survived more than 10 years, and a third remains alive without disease at 26 months.
Conclusions. Complete resection and multimodality therapy result in long‐term survival for a subgroup of patients with anaplastic thyroid carcinoma. © 1995 Jons Wiley & Sons, Inc. |
| doi_str_mv | 10.1002/hed.2880170109 |
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Methods. Twenty‐one cases of anaplastic carcinoma of the thyroid gland were analyzed retorspectively with respect to prognostic factors influencing survival. This represents 2.7% of 771 cases of thyroid cancer seen at our institution from 1968 to 1992. The median age at presentation was 65.1 years; male/female ratio was 1:1.1; and the most common symptom was a rapidly enlarging neck mass (76%).
Results. Estimated 5‐year survival was 10% (median: 4.5 months). Tumor size less than 6.0 cm (p = .004) and female gender (p = .02) were significant prognostic factors. Five patients who underwent complete resection had an estimated 5‐year survival of 60% (median: 131 months). Four of these patients had postoperative radiotherapy with or without sequential chemotherapy. Two of these patients survived more than 10 years, and a third remains alive without disease at 26 months.
Conclusions. Complete resection and multimodality therapy result in long‐term survival for a subgroup of patients with anaplastic thyroid carcinoma. © 1995 Jons Wiley & Sons, Inc.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.2880170109</identifier><identifier>PMID: 7883548</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma - mortality ; Carcinoma - pathology ; Carcinoma - surgery ; Carcinoma, Giant Cell - mortality ; Cause of Death ; Combined Modality Therapy ; Disease-Free Survival ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; New York - epidemiology ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology ; Prognosis ; Retrospective Studies ; Sex Factors ; Survival Rate ; Thyroid Neoplasms - mortality ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - surgery ; Thyroidectomy ; Treatment Outcome ; Tumors</subject><ispartof>Head & neck, 1995-01, Vol.17 (1), p.41-48</ispartof><rights>Copyright © 1995 Wiley Periodicals, Inc., A Wiley Company</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4739-db9bc4005706bbac6984e3258f03404305821dc224e1f961e82481a270eda67e3</citedby><cites>FETCH-LOGICAL-c4739-db9bc4005706bbac6984e3258f03404305821dc224e1f961e82481a270eda67e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.2880170109$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.2880170109$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4009,27902,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3469769$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7883548$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, Raymond K.</creatorcontrib><creatorcontrib>Finley III, Robert K.</creatorcontrib><creatorcontrib>Driscoll, Deborah</creatorcontrib><creatorcontrib>Bakamjian, Vahram</creatorcontrib><creatorcontrib>Hicks Jr, Wesley L.</creatorcontrib><creatorcontrib>Shedd, Donald P.</creatorcontrib><title>Anaplastic carcinoma of the thyroid: A 24-year experience</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background. Anaplastic carcinoma of the thyroid gland is a lethal entity; few patients live more than 12 months following diagnosis. We retrospectively reviewed the experience with this entity at our cancer institute and identified a subgroup of patients with complete resection who have a 60% 5‐year survival.
Methods. Twenty‐one cases of anaplastic carcinoma of the thyroid gland were analyzed retorspectively with respect to prognostic factors influencing survival. This represents 2.7% of 771 cases of thyroid cancer seen at our institution from 1968 to 1992. The median age at presentation was 65.1 years; male/female ratio was 1:1.1; and the most common symptom was a rapidly enlarging neck mass (76%).
Results. Estimated 5‐year survival was 10% (median: 4.5 months). Tumor size less than 6.0 cm (p = .004) and female gender (p = .02) were significant prognostic factors. Five patients who underwent complete resection had an estimated 5‐year survival of 60% (median: 131 months). Four of these patients had postoperative radiotherapy with or without sequential chemotherapy. Two of these patients survived more than 10 years, and a third remains alive without disease at 26 months.
Conclusions. Complete resection and multimodality therapy result in long‐term survival for a subgroup of patients with anaplastic thyroid carcinoma. © 1995 Jons Wiley & Sons, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma - mortality</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma - surgery</subject><subject>Carcinoma, Giant Cell - mortality</subject><subject>Cause of Death</subject><subject>Combined Modality Therapy</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>New York - epidemiology</subject><subject>Otorhinolaryngology (head neck, general aspects and miscellaneous)</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Sex Factors</subject><subject>Survival Rate</subject><subject>Thyroid Neoplasms - mortality</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroidectomy</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUDtPIzEQthCI44CW7qQtEN2G8WP9uC7ieQqCJojS8npnhWGzm7MTQf49jpIDXUUxHkvfYz59hJxQGFEAdv6MzYhpDVQBBbNDDvKrSuBC7a7_gpcclPhBfqb0AgBcCrZP9pXWvBL6gJhx7-adS4vgC--iD_0wc8XQFotnzLOKQ2h-F-OCiXKFLhb4PscYsPd4RPZa1yU83u5D8nh9Nb24Le8ebv5cjO9KLxQ3ZVOb2guASoGsa-el0QI5q3SbM-Z4UGlGG8-YQNoaSVEzoaljCrBxUiE_JGcb33kc_i4xLewsJI9d53oclskqRaU2XGfiaEP0cUgpYmvnMcxcXFkKdt2VzV3Zr66y4NfWeVnPMvSPvi0n46db3CXvuja63of0SeNCGiXXNmZDewsdrr45am-vLv-LUG60IS3w_VPr4quViqvKPt3fWJhMpnJ6PbGafwC0U45W</recordid><startdate>199501</startdate><enddate>199501</enddate><creator>Tan, Raymond K.</creator><creator>Finley III, Robert K.</creator><creator>Driscoll, Deborah</creator><creator>Bakamjian, Vahram</creator><creator>Hicks Jr, Wesley L.</creator><creator>Shedd, Donald P.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>John Wiley & Sons</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199501</creationdate><title>Anaplastic carcinoma of the thyroid: A 24-year experience</title><author>Tan, Raymond K. ; Finley III, Robert K. ; Driscoll, Deborah ; Bakamjian, Vahram ; Hicks Jr, Wesley L. ; Shedd, Donald P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4739-db9bc4005706bbac6984e3258f03404305821dc224e1f961e82481a270eda67e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma - mortality</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma - surgery</topic><topic>Carcinoma, Giant Cell - mortality</topic><topic>Cause of Death</topic><topic>Combined Modality Therapy</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>New York - epidemiology</topic><topic>Otorhinolaryngology (head neck, general aspects and miscellaneous)</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Sex Factors</topic><topic>Survival Rate</topic><topic>Thyroid Neoplasms - mortality</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroidectomy</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, Raymond K.</creatorcontrib><creatorcontrib>Finley III, Robert K.</creatorcontrib><creatorcontrib>Driscoll, Deborah</creatorcontrib><creatorcontrib>Bakamjian, Vahram</creatorcontrib><creatorcontrib>Hicks Jr, Wesley L.</creatorcontrib><creatorcontrib>Shedd, Donald P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, Raymond K.</au><au>Finley III, Robert K.</au><au>Driscoll, Deborah</au><au>Bakamjian, Vahram</au><au>Hicks Jr, Wesley L.</au><au>Shedd, Donald P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anaplastic carcinoma of the thyroid: A 24-year experience</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>1995-01</date><risdate>1995</risdate><volume>17</volume><issue>1</issue><spage>41</spage><epage>48</epage><pages>41-48</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background. Anaplastic carcinoma of the thyroid gland is a lethal entity; few patients live more than 12 months following diagnosis. We retrospectively reviewed the experience with this entity at our cancer institute and identified a subgroup of patients with complete resection who have a 60% 5‐year survival.
Methods. Twenty‐one cases of anaplastic carcinoma of the thyroid gland were analyzed retorspectively with respect to prognostic factors influencing survival. This represents 2.7% of 771 cases of thyroid cancer seen at our institution from 1968 to 1992. The median age at presentation was 65.1 years; male/female ratio was 1:1.1; and the most common symptom was a rapidly enlarging neck mass (76%).
Results. Estimated 5‐year survival was 10% (median: 4.5 months). Tumor size less than 6.0 cm (p = .004) and female gender (p = .02) were significant prognostic factors. Five patients who underwent complete resection had an estimated 5‐year survival of 60% (median: 131 months). Four of these patients had postoperative radiotherapy with or without sequential chemotherapy. Two of these patients survived more than 10 years, and a third remains alive without disease at 26 months.
Conclusions. Complete resection and multimodality therapy result in long‐term survival for a subgroup of patients with anaplastic thyroid carcinoma. © 1995 Jons Wiley & Sons, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>7883548</pmid><doi>10.1002/hed.2880170109</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma - mortality Carcinoma - pathology Carcinoma - surgery Carcinoma, Giant Cell - mortality Cause of Death Combined Modality Therapy Disease-Free Survival Female Humans Male Medical sciences Middle Aged New York - epidemiology Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Prognosis Retrospective Studies Sex Factors Survival Rate Thyroid Neoplasms - mortality Thyroid Neoplasms - pathology Thyroid Neoplasms - surgery Thyroidectomy Treatment Outcome Tumors |
| title | Anaplastic carcinoma of the thyroid: A 24-year experience |
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