Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism

Autism is a complex neurodevelopmental disorder that usually presents in early childhood and that is thought to be influenced by genetic and environmental factors. Although abnormal metabolism of methionine and homocysteine has been associated with other neurologic diseases, these pathways have not...

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Veröffentlicht in:	The American journal of clinical nutrition 2004-12, Vol.80 (6), p.1611-1617
Hauptverfasser:	James, S Jill, Cutler, Paul, Melnyk, Stepan, Jernigan, Stefanie, Janak, Laurette, Gaylor, David W, Neubrander, James A
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine Adenosine - blood Adenosine - metabolism amino acid derivatives amino acid metabolism Autism Autistic disorder Autistic Disorder - blood Autistic Disorder - drug therapy Autistic Disorder - metabolism Betaine - administration & dosage Biological and medical sciences biomarkers Biomarkers - blood blood chemistry Case-Control Studies Child Child clinical studies children Children & youth Chromatography, High Pressure Liquid - methods cystathionine Cystathionine - blood Cystathionine - metabolism cysteine Cysteine - blood Cysteine - metabolism Developmental disorders Female glutathione Glutathione - blood Glutathione - metabolism homocysteine Homocysteine - blood Homocysteine - metabolism Humans Infantile autism Leucovorin - administration & dosage Male Medical sciences methionine Methionine - blood Methionine - metabolism Methylation nervous system diseases Nutrition Oxidation oxidative stress Oxidative Stress - drug effects Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry S-adenosylhomocysteine S-Adenosylhomocysteine - blood S-Adenosylhomocysteine - metabolism S-adenosylmethionine S-Adenosylmethionine - blood S-Adenosylmethionine - metabolism Stress Vitamin B 12 - administration & dosage Vitamin B 12 - analogs & derivatives
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