Metabolite profiling and chemopreventive bioactivity of plant extracts from Bidens pilosa
Bidens pilosa has been used as a folk medicine in various medications and as a popular ingredient in herb teas. Chemopreventive activities of crude and fractionated plant extracts of Bidens pilosa were evaluated in this study. Ethyl acetate and butanolic fractions, partitioned from the total crude e...
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| Veröffentlicht in: | Journal of ethnopharmacology 2004-12, Vol.95 (2), p.409-419 |
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| creator | Chiang, Yi-Ming Chuang, Da-Yung Wang, Sheng-Yang Kuo, Yueh-Hsiung Tsai, Pi-Wen Shyur, Lie-Fen |
| description | Bidens pilosa has been used as a folk medicine in various medications and as a popular ingredient in herb teas. Chemopreventive activities of crude and fractionated plant extracts of
Bidens pilosa were evaluated in this study. Ethyl acetate and butanolic fractions, partitioned from the total crude extract of
Bidens pilosa, exhibited significant scavenging free radical activity (IC
50 values ≅ 14–17
μg/mL) comparable to that of α-tocopherol. Strong effects on the inhibition of LPS-mediated nitric oxide production in RAW 264.7 cells were also observed for the EA and BuOH fractions. Detectable cytotoxicity on RAW 264.7 cells, however, was observed for the EA fraction at a dose >100
μg/ml. The metabolite profile and major constituents of the BuOH fraction were studied and characterized using various spectroscopic analyses. A new compound, heptanyl 2-
O-β-xylofuranosyl-(1→6)-β-glucopyranoside (
1), and eight phenolic compounds, namely quercetin 3-
O-rabinobioside (
2), quercetin 3-
O-rutinoside (
3), chlorogenic acid (
4), 3,4-di-
O-caffeoylquinic acid (
5), 3,5-di-
O-caffeoylquinic acid (
6), 4,5-di-
O-caffeoylquinic acid (
7), jacein (
8), centaurein (
9) were for the first time isolated from
Bidens pilosa. Compounds
2–7 are the major antioxidative constituents in the
Bidens pilosa extract. |
| doi_str_mv | 10.1016/j.jep.2004.08.010 |
| format | Article |
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Bidens pilosa were evaluated in this study. Ethyl acetate and butanolic fractions, partitioned from the total crude extract of
Bidens pilosa, exhibited significant scavenging free radical activity (IC
50 values ≅ 14–17
μg/mL) comparable to that of α-tocopherol. Strong effects on the inhibition of LPS-mediated nitric oxide production in RAW 264.7 cells were also observed for the EA and BuOH fractions. Detectable cytotoxicity on RAW 264.7 cells, however, was observed for the EA fraction at a dose >100
μg/ml. The metabolite profile and major constituents of the BuOH fraction were studied and characterized using various spectroscopic analyses. A new compound, heptanyl 2-
O-β-xylofuranosyl-(1→6)-β-glucopyranoside (
1), and eight phenolic compounds, namely quercetin 3-
O-rabinobioside (
2), quercetin 3-
O-rutinoside (
3), chlorogenic acid (
4), 3,4-di-
O-caffeoylquinic acid (
5), 3,5-di-
O-caffeoylquinic acid (
6), 4,5-di-
O-caffeoylquinic acid (
7), jacein (
8), centaurein (
9) were for the first time isolated from
Bidens pilosa. Compounds
2–7 are the major antioxidative constituents in the
Bidens pilosa extract.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2004.08.010</identifier><identifier>PMID: 15507368</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; antioxidant activity ; Antioxidants - isolation & purification ; Antioxidants - metabolism ; Antioxidants - pharmacology ; Bidens - metabolism ; Bidens pilosa ; Biological and medical sciences ; Cell Line ; Cell Survival - drug effects ; Cell Survival - physiology ; Chemoprevention ; Chemopreventive bioactivities ; Dose-Response Relationship, Drug ; General pharmacology ; Medical sciences ; medicinal plants ; Medicine, Chinese Traditional ; Metabolite profile ; Mice ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phenolic compounds ; phytochemicals ; plant extracts ; Plant Extracts - isolation & purification ; Plant Extracts - metabolism ; Plant Extracts - pharmacology ; Plant Structures ; traditional medicine</subject><ispartof>Journal of ethnopharmacology, 2004-12, Vol.95 (2), p.409-419</ispartof><rights>2004 Elsevier Ireland Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-cf35551126c0fe1362ea0ded6d21433a1f407ac218902df2be4a26e1e2af14973</citedby><cites>FETCH-LOGICAL-c435t-cf35551126c0fe1362ea0ded6d21433a1f407ac218902df2be4a26e1e2af14973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378874104003812$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16238714$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15507368$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chiang, Yi-Ming</creatorcontrib><creatorcontrib>Chuang, Da-Yung</creatorcontrib><creatorcontrib>Wang, Sheng-Yang</creatorcontrib><creatorcontrib>Kuo, Yueh-Hsiung</creatorcontrib><creatorcontrib>Tsai, Pi-Wen</creatorcontrib><creatorcontrib>Shyur, Lie-Fen</creatorcontrib><title>Metabolite profiling and chemopreventive bioactivity of plant extracts from Bidens pilosa</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Bidens pilosa has been used as a folk medicine in various medications and as a popular ingredient in herb teas. Chemopreventive activities of crude and fractionated plant extracts of
Bidens pilosa were evaluated in this study. Ethyl acetate and butanolic fractions, partitioned from the total crude extract of
Bidens pilosa, exhibited significant scavenging free radical activity (IC
50 values ≅ 14–17
μg/mL) comparable to that of α-tocopherol. Strong effects on the inhibition of LPS-mediated nitric oxide production in RAW 264.7 cells were also observed for the EA and BuOH fractions. Detectable cytotoxicity on RAW 264.7 cells, however, was observed for the EA fraction at a dose >100
μg/ml. The metabolite profile and major constituents of the BuOH fraction were studied and characterized using various spectroscopic analyses. A new compound, heptanyl 2-
O-β-xylofuranosyl-(1→6)-β-glucopyranoside (
1), and eight phenolic compounds, namely quercetin 3-
O-rabinobioside (
2), quercetin 3-
O-rutinoside (
3), chlorogenic acid (
4), 3,4-di-
O-caffeoylquinic acid (
5), 3,5-di-
O-caffeoylquinic acid (
6), 4,5-di-
O-caffeoylquinic acid (
7), jacein (
8), centaurein (
9) were for the first time isolated from
Bidens pilosa. Compounds
2–7 are the major antioxidative constituents in the
Bidens pilosa extract.</description><subject>Animals</subject><subject>antioxidant activity</subject><subject>Antioxidants - isolation & purification</subject><subject>Antioxidants - metabolism</subject><subject>Antioxidants - pharmacology</subject><subject>Bidens - metabolism</subject><subject>Bidens pilosa</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Cell Survival - drug effects</subject><subject>Cell Survival - physiology</subject><subject>Chemoprevention</subject><subject>Chemopreventive bioactivities</subject><subject>Dose-Response Relationship, Drug</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>Medicine, Chinese Traditional</subject><subject>Metabolite profile</subject><subject>Mice</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenolic compounds</subject><subject>phytochemicals</subject><subject>plant extracts</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - metabolism</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Structures</subject><subject>traditional medicine</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90U1v1DAQBmALgehS-AFcwBfKKWHGTuysOEHFl1TEAXrgZHmdcfEqiVM7u2r_PV7tSr31ZMt6ZvTqNWOvEWoEVB-29ZbmWgA0NXQ1IDxhK-y0qHSr5VO2Aqm7qtMNnrEXOW8BQGMDz9kZti1oqboV-_uTFruJQ1iIzyn6MITphtup5-4fjXFOtKdpCXvimxCtK7ew3PPo-TzYaeF0t6TymrlPceSfQ09T5nMYYrYv2TNvh0yvTuc5u_765c_l9-rq17cfl5-uKtfIdqmcl23bIgrlwBNKJchCT73qBTZSWvQNaOsEdmsQvRcbaqxQhCSsx2at5Tl7f9xb4t_uKC9mDNnRUPJR3GWjNSrVKBRFXjwqlQaUCAeIR-hSzDmRN3MKo033BsEcmjdbU5o3h-YNdKY0X2benJbvNiP1DxOnqgt4dwI2Ozv4ZCcX8oNTQnble4p7e3TeRmNvUjHXv0VJBrDuAAQW8fEoqNS6D5RMdoEmR31I5BbTx_BI0P-nHqpH</recordid><startdate>20041201</startdate><enddate>20041201</enddate><creator>Chiang, Yi-Ming</creator><creator>Chuang, Da-Yung</creator><creator>Wang, Sheng-Yang</creator><creator>Kuo, Yueh-Hsiung</creator><creator>Tsai, Pi-Wen</creator><creator>Shyur, Lie-Fen</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041201</creationdate><title>Metabolite profiling and chemopreventive bioactivity of plant extracts from Bidens pilosa</title><author>Chiang, Yi-Ming ; Chuang, Da-Yung ; Wang, Sheng-Yang ; Kuo, Yueh-Hsiung ; Tsai, Pi-Wen ; Shyur, Lie-Fen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-cf35551126c0fe1362ea0ded6d21433a1f407ac218902df2be4a26e1e2af14973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>antioxidant activity</topic><topic>Antioxidants - isolation & purification</topic><topic>Antioxidants - metabolism</topic><topic>Antioxidants - pharmacology</topic><topic>Bidens - metabolism</topic><topic>Bidens pilosa</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Cell Survival - drug effects</topic><topic>Cell Survival - physiology</topic><topic>Chemoprevention</topic><topic>Chemopreventive bioactivities</topic><topic>Dose-Response Relationship, Drug</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>Medicine, Chinese Traditional</topic><topic>Metabolite profile</topic><topic>Mice</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenolic compounds</topic><topic>phytochemicals</topic><topic>plant extracts</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - metabolism</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Structures</topic><topic>traditional medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chiang, Yi-Ming</creatorcontrib><creatorcontrib>Chuang, Da-Yung</creatorcontrib><creatorcontrib>Wang, Sheng-Yang</creatorcontrib><creatorcontrib>Kuo, Yueh-Hsiung</creatorcontrib><creatorcontrib>Tsai, Pi-Wen</creatorcontrib><creatorcontrib>Shyur, Lie-Fen</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chiang, Yi-Ming</au><au>Chuang, Da-Yung</au><au>Wang, Sheng-Yang</au><au>Kuo, Yueh-Hsiung</au><au>Tsai, Pi-Wen</au><au>Shyur, Lie-Fen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolite profiling and chemopreventive bioactivity of plant extracts from Bidens pilosa</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2004-12-01</date><risdate>2004</risdate><volume>95</volume><issue>2</issue><spage>409</spage><epage>419</epage><pages>409-419</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>Bidens pilosa has been used as a folk medicine in various medications and as a popular ingredient in herb teas. Chemopreventive activities of crude and fractionated plant extracts of
Bidens pilosa were evaluated in this study. Ethyl acetate and butanolic fractions, partitioned from the total crude extract of
Bidens pilosa, exhibited significant scavenging free radical activity (IC
50 values ≅ 14–17
μg/mL) comparable to that of α-tocopherol. Strong effects on the inhibition of LPS-mediated nitric oxide production in RAW 264.7 cells were also observed for the EA and BuOH fractions. Detectable cytotoxicity on RAW 264.7 cells, however, was observed for the EA fraction at a dose >100
μg/ml. The metabolite profile and major constituents of the BuOH fraction were studied and characterized using various spectroscopic analyses. A new compound, heptanyl 2-
O-β-xylofuranosyl-(1→6)-β-glucopyranoside (
1), and eight phenolic compounds, namely quercetin 3-
O-rabinobioside (
2), quercetin 3-
O-rutinoside (
3), chlorogenic acid (
4), 3,4-di-
O-caffeoylquinic acid (
5), 3,5-di-
O-caffeoylquinic acid (
6), 4,5-di-
O-caffeoylquinic acid (
7), jacein (
8), centaurein (
9) were for the first time isolated from
Bidens pilosa. Compounds
2–7 are the major antioxidative constituents in the
Bidens pilosa extract.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>15507368</pmid><doi>10.1016/j.jep.2004.08.010</doi><tpages>11</tpages></addata></record> |
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| ispartof | Journal of ethnopharmacology, 2004-12, Vol.95 (2), p.409-419 |
| issn | 0378-8741 1872-7573 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals antioxidant activity Antioxidants - isolation & purification Antioxidants - metabolism Antioxidants - pharmacology Bidens - metabolism Bidens pilosa Biological and medical sciences Cell Line Cell Survival - drug effects Cell Survival - physiology Chemoprevention Chemopreventive bioactivities Dose-Response Relationship, Drug General pharmacology Medical sciences medicinal plants Medicine, Chinese Traditional Metabolite profile Mice Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenolic compounds phytochemicals plant extracts Plant Extracts - isolation & purification Plant Extracts - metabolism Plant Extracts - pharmacology Plant Structures traditional medicine |
| title | Metabolite profiling and chemopreventive bioactivity of plant extracts from Bidens pilosa |
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