Effects of opioids and opioid peptide on the release of substance P-like material induced by tooth pulp stimulation in the trigeminal nucleus caudalis of the rabbit
The superficial layer in subnucleus caudalis of the brain-stem trigeminal sensory nuclear complex (SpVc) in the rabbit was perfused with artificial cerebrospinal fluid using a push-pull perfusion cannula system. Immunoreactive substance P (iSP) and [Met 5]enkephalin (iME) released into the perfusate...
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| Veröffentlicht in: | European journal of pharmacology 1986-10, Vol.129 (3), p.209-216 |
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| creator | Yonehara, Norifumi Shibutani, Tooru Tsai, Huei-Yann Inoki, Reizo |
| description | The superficial layer in subnucleus caudalis of the brain-stem trigeminal sensory nuclear complex (SpVc) in the rabbit was perfused with artificial cerebrospinal fluid using a push-pull perfusion cannula system. Immunoreactive substance P (iSP) and [Met
5]enkephalin (iME) released into the perfusates following electrical stimulation of the lower incisor pulp were measured. An increase in the release of iSP and iME lasting for 1 h or more was observed following electrical stimulation with 40 V. The increase in iSP release depended on the intensity of stimulation. Systemic morphine (10 mg/kg i.v.) completely inhibited the stimulus-evoked iSP release and this inhibition was antagonized by pretreatment with naloxone (5 mg/kg i.v.). The stimulus-evoked iSP release was also inhibited by local application of morphine (10
−6 M) or the opioid peptide [D-Ala
2,Met
5]enkephalinamide (10
−4 M). However, the local application of naloxone (5 × 10
−7 M) only partially antagonized the inhibitory effect of locally applied morphine and the opioid peptide. These results suggest that ther is a functional interaction between SP and enkephalin system in the superficial layer of SpVc for the regulation of dental pain transmission. |
| doi_str_mv | 10.1016/0014-2999(86)90430-9 |
| format | Article |
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5]enkephalin (iME) released into the perfusates following electrical stimulation of the lower incisor pulp were measured. An increase in the release of iSP and iME lasting for 1 h or more was observed following electrical stimulation with 40 V. The increase in iSP release depended on the intensity of stimulation. Systemic morphine (10 mg/kg i.v.) completely inhibited the stimulus-evoked iSP release and this inhibition was antagonized by pretreatment with naloxone (5 mg/kg i.v.). The stimulus-evoked iSP release was also inhibited by local application of morphine (10
−6 M) or the opioid peptide [D-Ala
2,Met
5]enkephalinamide (10
−4 M). However, the local application of naloxone (5 × 10
−7 M) only partially antagonized the inhibitory effect of locally applied morphine and the opioid peptide. These results suggest that ther is a functional interaction between SP and enkephalin system in the superficial layer of SpVc for the regulation of dental pain transmission.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(86)90430-9</identifier><identifier>PMID: 2430813</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>[met 5]enkephalin-like material ; Animals ; Applied sciences ; Biological and medical sciences ; Dental Pulp - physiology ; Electric Stimulation ; Enkephalin, Methionine - analogs & derivatives ; Enkephalin, Methionine - metabolism ; Enkephalin, Methionine - pharmacology ; Exact sciences and technology ; Fundamental and applied biological sciences. Psychology ; In vivo release ; Male ; Morphine - pharmacology ; Naloxone - pharmacology ; Opioid and opioid peptide ; Other techniques and industries ; Pain - physiopathology ; Rabbits ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Subnucleus caudalis of the brain-stem trigeminal sensory nuclear complex ; Substance P - metabolism ; Substance P-like material ; Tooth pulp stimulation ; Trigeminal Nuclei - drug effects ; Trigeminal Nuclei - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>European journal of pharmacology, 1986-10, Vol.129 (3), p.209-216</ispartof><rights>1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-c36358568e3f2afa7b33c0be8443ab4f0a66944d813116d79f82f1e701821b83</citedby><cites>FETCH-LOGICAL-c481t-c36358568e3f2afa7b33c0be8443ab4f0a66944d813116d79f82f1e701821b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-2999(86)90430-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8320045$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8349513$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2430813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yonehara, Norifumi</creatorcontrib><creatorcontrib>Shibutani, Tooru</creatorcontrib><creatorcontrib>Tsai, Huei-Yann</creatorcontrib><creatorcontrib>Inoki, Reizo</creatorcontrib><title>Effects of opioids and opioid peptide on the release of substance P-like material induced by tooth pulp stimulation in the trigeminal nucleus caudalis of the rabbit</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The superficial layer in subnucleus caudalis of the brain-stem trigeminal sensory nuclear complex (SpVc) in the rabbit was perfused with artificial cerebrospinal fluid using a push-pull perfusion cannula system. Immunoreactive substance P (iSP) and [Met
5]enkephalin (iME) released into the perfusates following electrical stimulation of the lower incisor pulp were measured. An increase in the release of iSP and iME lasting for 1 h or more was observed following electrical stimulation with 40 V. The increase in iSP release depended on the intensity of stimulation. Systemic morphine (10 mg/kg i.v.) completely inhibited the stimulus-evoked iSP release and this inhibition was antagonized by pretreatment with naloxone (5 mg/kg i.v.). The stimulus-evoked iSP release was also inhibited by local application of morphine (10
−6 M) or the opioid peptide [D-Ala
2,Met
5]enkephalinamide (10
−4 M). However, the local application of naloxone (5 × 10
−7 M) only partially antagonized the inhibitory effect of locally applied morphine and the opioid peptide. These results suggest that ther is a functional interaction between SP and enkephalin system in the superficial layer of SpVc for the regulation of dental pain transmission.</description><subject>[met 5]enkephalin-like material</subject><subject>Animals</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Dental Pulp - physiology</subject><subject>Electric Stimulation</subject><subject>Enkephalin, Methionine - analogs & derivatives</subject><subject>Enkephalin, Methionine - metabolism</subject><subject>Enkephalin, Methionine - pharmacology</subject><subject>Exact sciences and technology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In vivo release</subject><subject>Male</subject><subject>Morphine - pharmacology</subject><subject>Naloxone - pharmacology</subject><subject>Opioid and opioid peptide</subject><subject>Other techniques and industries</subject><subject>Pain - physiopathology</subject><subject>Rabbits</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Subnucleus caudalis of the brain-stem trigeminal sensory nuclear complex</subject><subject>Substance P - metabolism</subject><subject>Substance P-like material</subject><subject>Tooth pulp stimulation</subject><subject>Trigeminal Nuclei - drug effects</subject><subject>Trigeminal Nuclei - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcuKFTEURYMo7bX1DxQyENFBaVJJVSUTQZr2AQ066HlIJSd2NFUp8xD6f_xQcx_coThK4Ky9c7I3Qs8peUsJHd8RQnnXSylfi_GNJJyRTj5AOyom2ZGJ9g_R7ow8Rk9y_kEIGWQ_XKCLvtGCsh36c-0cmJJxdDhuPnqbsV7t6Y432Iq3gOOKyx3gBAF0hj2c65yLXg3gb13wPwEvukDyOmC_2mrA4vkelxjLHd5q2HAufqlBF9-s_NGtJP8dFr82zVpNgJqx0dXq4A_rHB7U8-zLU_TI6ZDh2em8RLcfr2-vPnc3Xz99ufpw0xkuaOkMG9kghlEAc712epoZM2QGwTnTM3dEj6Pk3LaPUzraSTrROwoToaKns2CX6NXRdkvxV4Vc1OKzgRD0CrFmNU10HCY2NZAfQZNizgmc2pJfdLpXlKh9N2ofvNoHr8SoDt0o2WQvTv51XsCeRacy2vzlaa6z0cGlFq_PZ0wwLof_wXpC-NCw90cMWmK_PSSVjYdWmPWpNa5s9P9e9y-51blc</recordid><startdate>19861007</startdate><enddate>19861007</enddate><creator>Yonehara, Norifumi</creator><creator>Shibutani, Tooru</creator><creator>Tsai, Huei-Yann</creator><creator>Inoki, Reizo</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19861007</creationdate><title>Effects of opioids and opioid peptide on the release of substance P-like material induced by tooth pulp stimulation in the trigeminal nucleus caudalis of the rabbit</title><author>Yonehara, Norifumi ; Shibutani, Tooru ; Tsai, Huei-Yann ; Inoki, Reizo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-c36358568e3f2afa7b33c0be8443ab4f0a66944d813116d79f82f1e701821b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>[met 5]enkephalin-like material</topic><topic>Animals</topic><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>Dental Pulp - physiology</topic><topic>Electric Stimulation</topic><topic>Enkephalin, Methionine - analogs & derivatives</topic><topic>Enkephalin, Methionine - metabolism</topic><topic>Enkephalin, Methionine - pharmacology</topic><topic>Exact sciences and technology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>In vivo release</topic><topic>Male</topic><topic>Morphine - pharmacology</topic><topic>Naloxone - pharmacology</topic><topic>Opioid and opioid peptide</topic><topic>Other techniques and industries</topic><topic>Pain - physiopathology</topic><topic>Rabbits</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Subnucleus caudalis of the brain-stem trigeminal sensory nuclear complex</topic><topic>Substance P - metabolism</topic><topic>Substance P-like material</topic><topic>Tooth pulp stimulation</topic><topic>Trigeminal Nuclei - drug effects</topic><topic>Trigeminal Nuclei - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yonehara, Norifumi</creatorcontrib><creatorcontrib>Shibutani, Tooru</creatorcontrib><creatorcontrib>Tsai, Huei-Yann</creatorcontrib><creatorcontrib>Inoki, Reizo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yonehara, Norifumi</au><au>Shibutani, Tooru</au><au>Tsai, Huei-Yann</au><au>Inoki, Reizo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of opioids and opioid peptide on the release of substance P-like material induced by tooth pulp stimulation in the trigeminal nucleus caudalis of the rabbit</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1986-10-07</date><risdate>1986</risdate><volume>129</volume><issue>3</issue><spage>209</spage><epage>216</epage><pages>209-216</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>The superficial layer in subnucleus caudalis of the brain-stem trigeminal sensory nuclear complex (SpVc) in the rabbit was perfused with artificial cerebrospinal fluid using a push-pull perfusion cannula system. Immunoreactive substance P (iSP) and [Met
5]enkephalin (iME) released into the perfusates following electrical stimulation of the lower incisor pulp were measured. An increase in the release of iSP and iME lasting for 1 h or more was observed following electrical stimulation with 40 V. The increase in iSP release depended on the intensity of stimulation. Systemic morphine (10 mg/kg i.v.) completely inhibited the stimulus-evoked iSP release and this inhibition was antagonized by pretreatment with naloxone (5 mg/kg i.v.). The stimulus-evoked iSP release was also inhibited by local application of morphine (10
−6 M) or the opioid peptide [D-Ala
2,Met
5]enkephalinamide (10
−4 M). However, the local application of naloxone (5 × 10
−7 M) only partially antagonized the inhibitory effect of locally applied morphine and the opioid peptide. These results suggest that ther is a functional interaction between SP and enkephalin system in the superficial layer of SpVc for the regulation of dental pain transmission.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2430813</pmid><doi>10.1016/0014-2999(86)90430-9</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 1986-10, Vol.129 (3), p.209-216 |
| issn | 0014-2999 1879-0712 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77165737 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | [met 5]enkephalin-like material Animals Applied sciences Biological and medical sciences Dental Pulp - physiology Electric Stimulation Enkephalin, Methionine - analogs & derivatives Enkephalin, Methionine - metabolism Enkephalin, Methionine - pharmacology Exact sciences and technology Fundamental and applied biological sciences. Psychology In vivo release Male Morphine - pharmacology Naloxone - pharmacology Opioid and opioid peptide Other techniques and industries Pain - physiopathology Rabbits Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Subnucleus caudalis of the brain-stem trigeminal sensory nuclear complex Substance P - metabolism Substance P-like material Tooth pulp stimulation Trigeminal Nuclei - drug effects Trigeminal Nuclei - metabolism Vertebrates: nervous system and sense organs |
| title | Effects of opioids and opioid peptide on the release of substance P-like material induced by tooth pulp stimulation in the trigeminal nucleus caudalis of the rabbit |
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