Structures of Aromatic Inhibitors of Influenza Virus Neuraminidase

Neuraminidase (NA), a surface glycoprotein of influenza virus, is a potential target for design of antiinfluenza agents. The crystal structure of influenza virus neuraminidase showed that in the active site 11 residues are universally conserved among all strains known so far. Several potent inhibito...

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Veröffentlicht in:	Biochemistry (Easton) 1995-03, Vol.34 (10), p.3144-3151
Hauptverfasser:	Jedrzejas, Marek J, Singh, Sangeeta, Brouillette, Wayne J, Laver, W. Graeme, Air, Gillian M, Luo, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminobenzoates - chemical synthesis Aminobenzoates - chemistry Aminobenzoates - pharmacology Animals Binding Sites Electrochemistry influenza virus Models, Molecular Molecular Structure N-Acetylneuraminic Acid - analogs & derivatives Neuraminidase - antagonists & inhibitors Neuraminidase - chemistry Nitrobenzoates - chemical synthesis Nitrobenzoates - chemistry Nitrobenzoates - pharmacology Orthomyxoviridae - enzymology Protein Conformation Sialic Acids - chemistry Sialic Acids - pharmacology Structure-Activity Relationship
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