Post-transcriptional Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme-A Reductase by Mevalonate

We have examined the mechanisms of sterol-independent regulation of the expression of 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase by mevalonate in Chinese hamster ovary (CHO) cells. Serum lipoproteins, 25-hydroxycholesterol, or mevalonate each repress HMG-CoA reductase activity by five...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1995-02, Vol.317 (1), p.235-243
Hauptverfasser:	Straka, M.S., Panini, S.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CHO Cells Cholesterol - metabolism Cricetinae Gene Transfer Techniques Hydroxymethylglutaryl CoA Reductases - genetics Hydroxymethylglutaryl CoA Reductases - metabolism Mevalonic Acid - metabolism Mevalonic Acid - pharmacology Promoter Regions, Genetic Receptors, LDL - genetics Receptors, LDL - metabolism RNA Processing, Post-Transcriptional RNA, Messenger - genetics RNA, Messenger - metabolism
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