Tetrahydrofuran lignans from Nectandra megapotamica with trypanocidal activity

The phytochemical investigation of the crude ethanol extract of the leaves of Nectandra megapotamica afforded three new (2d, 3b, and 3c) and eight known (1a-d, 2a-c, and 3a) tetrahydrofuran lignans. Regarding the in vitro trypanocidal activity, the lignan-rich fraction, at a concentration of 2.0 mg/...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2004-01, Vol.67 (1), p.42-45
Hauptverfasser:	Silva Filho, A.A. da, Albuquerque, S, Silva, M.L.A, Eberlin, M.N, Tomazela, D.M, Bastos, J.K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brazil Furans - chemistry Furans - isolation & purification Furans - pharmacology General pharmacology Inhibitory Concentration 50 Lauraceae - chemistry Lignans - chemistry Lignans - isolation & purification Lignans - pharmacology Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Leaves - chemistry Plants, Medicinal - chemistry Stereoisomerism Structure-Activity Relationship Trypanocidal Agents - chemistry Trypanocidal Agents - isolation & purification Trypanocidal Agents - pharmacology Trypanosoma cruzi - drug effects
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