Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor

ALTHOUGH pharmacological doses of retinoic acid (RA) have a wide variety of actions in vivo 1 , experimental difficulties have prevented a definitive assignment of its physiological functions. We recently made a dominant-negative retinoic acid receptor (RAR>) by a single amino-acid substitution 2...

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Veröffentlicht in:	Nature (London) 1995-03, Vol.374 (6518), p.159-162
Hauptverfasser:	Saitou, Mitinori, Sugai, Satoshi, Tanaka, Toshihiro, Shimouchi, Koji, Fuchs, Elaine, Narumiya, Shuh, Kakizuka, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Biochemistry Biological and medical sciences Embryology: invertebrates and vertebrates. Teratology Embryonic and Fetal Development - physiology Epidermis Experimental organogenesis Female Fetuses Fundamental and applied biological sciences. Psychology Genes, Dominant Hormones Humanities and Social Sciences Keratins - biosynthesis letter Mice Mice, Transgenic multidisciplinary Mutation Organogenesis. Physiological fonctions Receptors, Retinoic Acid - genetics Receptors, Retinoic Acid - physiology Receptors, Thyroid Hormone - genetics Receptors, Thyroid Hormone - physiology Rodents Science Science (multidisciplinary) Skin Skin - embryology Skin - pathology Skin Physiological Phenomena Thyroid Tretinoin - pharmacology
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