Increased expression of IL-4 and IL-10 and decreased expression of IL-2 and interferon-γ in long-surviving mouse heart allografts after brief CD4-monoclonal antibody therapy

In a mouse model for vascularized heart transplantation, CBA recipients of BALB/c hearts were treated with 0.25 mg of anti-CD4 (GK1.5) given intraperitoneally on the day of grafting and on days 1, 2, and 3 thereafter. This reduced splenic CD4+ cells to < 1% and all grafts survived > 100 days,...

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Veröffentlicht in:	Transplantation 1995-02, Vol.59 (4), p.559-565
Hauptverfasser:	MOTTRAM, P. L, WEN-RUO HAN, PURCELL, L. J, MCKENZIE, I. F. C, HANCOCK, W. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - therapeutic use Biological and medical sciences CD4 Antigens - biosynthesis CD4 Antigens - immunology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology Graft Rejection - prevention & control Heart Transplantation Immunosuppression Interferon-gamma - antagonists & inhibitors Interferon-gamma - biosynthesis Interleukin-10 - biosynthesis Interleukin-2 - antagonists & inhibitors Interleukin-2 - biosynthesis Interleukin-4 - biosynthesis Medical sciences Mice Mice, Inbred BALB C Mice, Inbred CBA Skin Transplantation Spleen - immunology Spleen - pathology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Transplantation, Homologous
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