Substrate Specificity and Assembly of the Catalytic Center Derived from two Structures of Ligated Uridylate Kinase

Two crystal structures of ligated uridylate kinase fromSaccharomyces cerevisiaewere determined by X-ray analyses. The ligands were ADP and AMP. Cocrystallization with ATP yielded crystals with ADP at the ATP site and a mixture of AMp and ADP at the NMP site. Cocrystallization with ADP gave rise to a...

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Veröffentlicht in:	Journal of molecular biology 1995-03, Vol.246 (4), p.522-530
Hauptverfasser:	Muüller-Dieckmann, Hans-Joachim, Schulz, Georg E.
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine diphosphate Adenosine Diphosphate - metabolism adenosine monophosphate Adenosine Monophosphate - metabolism Amino Acid Sequence Binding Sites Catalysis catalytic center crystal structure Crystallization enzyme activity induced-fit kinases Models, Molecular molecular conformation Molecular Sequence Data Nucleoside-Phosphate Kinase - metabolism pdb/1uky pdb/1ukz Protein Structure, Secondary refined X-ray structure Saccharomyces cerevisiae Substrate Specificity Uridine Monophosphate - metabolism uridylate kinase X-ray diffraction
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