Glucagon-related peptides in the rat hypothalamus
Immunohistochemically, nerve fibers and terminals reacting with anti-N-terminal-specific but not with anti-C-terminal-specific glucagon antiserum were observed in the following rat hypothalamic regions: paraventricular nucleus, supraoptic nucleus, anterior hypothalamus, arcuate nucleus, ventromedial...
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| Veröffentlicht in: | Cell and tissue research 1986-01, Vol.246 (1), p.71-75 |
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| container_title | Cell and tissue research |
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| creator | INOKUCHI, A TOMIDA, Y YANAIHARA, C YUI, R OOMURA, Y KIMURA, H HASE, T MATSUMOTO, T YANAIHARA, N |
| description | Immunohistochemically, nerve fibers and terminals reacting with anti-N-terminal-specific but not with anti-C-terminal-specific glucagon antiserum were observed in the following rat hypothalamic regions: paraventricular nucleus, supraoptic nucleus, anterior hypothalamus, arcuate nucleus, ventromedial hypothalamic nucleus and median eminence. Few fibers and terminals were demonstrated in the lateral hypothalamic area and dorsomedial hypothalamic nucleus. Radioimmunoassay data indicated that the concentration of gut glucagon-like immunoreactivity was higher in the ventromedial nucleus than in the lateral hypothalamic area. In food-deprived conditions, this concentration increased in both these parts. This was also verified in immunostained preparations in which a marked enhancement of gut glucagon-like immunoreactivity-containing fibers and terminals was observed in many hypothalamic regions. Several immunoreactive cell bodies were found in the ventromedial and arcuate nuclei of starved rats. Both biochemical and morphological data suggest that glucagon-related peptides may act as neurotransmitters or neuromodulators in the hypothalamus and may be involved in the central regulatory mechanism related to feeding behavior and energy metabolism. |
| doi_str_mv | 10.1007/BF00219001 |
| format | Article |
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Few fibers and terminals were demonstrated in the lateral hypothalamic area and dorsomedial hypothalamic nucleus. Radioimmunoassay data indicated that the concentration of gut glucagon-like immunoreactivity was higher in the ventromedial nucleus than in the lateral hypothalamic area. In food-deprived conditions, this concentration increased in both these parts. This was also verified in immunostained preparations in which a marked enhancement of gut glucagon-like immunoreactivity-containing fibers and terminals was observed in many hypothalamic regions. Several immunoreactive cell bodies were found in the ventromedial and arcuate nuclei of starved rats. Both biochemical and morphological data suggest that glucagon-related peptides may act as neurotransmitters or neuromodulators in the hypothalamus and may be involved in the central regulatory mechanism related to feeding behavior and energy metabolism.</description><identifier>ISSN: 0302-766X</identifier><identifier>EISSN: 1432-0878</identifier><identifier>DOI: 10.1007/BF00219001</identifier><identifier>PMID: 3779802</identifier><identifier>CODEN: CTSRCS</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Biological and medical sciences ; Fasting ; Fundamental and applied biological sciences. Psychology ; Glucagon - immunology ; Glucagon-Like Peptides ; Hypothalamus - cytology ; Hypothalamus. Hypophysis. Epiphysis. Urophysis ; Immune Sera ; Immunoassay ; Morphology. Functional localizations ; Peptides - analysis ; Radioimmunoassay - methods ; Rats ; Vertebrates: endocrinology</subject><ispartof>Cell and tissue research, 1986-01, Vol.246 (1), p.71-75</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-911005b3b7fdac280b11d5e1ebc2a19bfd25f0c24f2c5c987b1c3fc5f8963cb83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8114923$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3779802$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>INOKUCHI, A</creatorcontrib><creatorcontrib>TOMIDA, Y</creatorcontrib><creatorcontrib>YANAIHARA, C</creatorcontrib><creatorcontrib>YUI, R</creatorcontrib><creatorcontrib>OOMURA, Y</creatorcontrib><creatorcontrib>KIMURA, H</creatorcontrib><creatorcontrib>HASE, T</creatorcontrib><creatorcontrib>MATSUMOTO, T</creatorcontrib><creatorcontrib>YANAIHARA, N</creatorcontrib><title>Glucagon-related peptides in the rat hypothalamus</title><title>Cell and tissue research</title><addtitle>Cell Tissue Res</addtitle><description>Immunohistochemically, nerve fibers and terminals reacting with anti-N-terminal-specific but not with anti-C-terminal-specific glucagon antiserum were observed in the following rat hypothalamic regions: paraventricular nucleus, supraoptic nucleus, anterior hypothalamus, arcuate nucleus, ventromedial hypothalamic nucleus and median eminence. Few fibers and terminals were demonstrated in the lateral hypothalamic area and dorsomedial hypothalamic nucleus. Radioimmunoassay data indicated that the concentration of gut glucagon-like immunoreactivity was higher in the ventromedial nucleus than in the lateral hypothalamic area. In food-deprived conditions, this concentration increased in both these parts. This was also verified in immunostained preparations in which a marked enhancement of gut glucagon-like immunoreactivity-containing fibers and terminals was observed in many hypothalamic regions. Several immunoreactive cell bodies were found in the ventromedial and arcuate nuclei of starved rats. Both biochemical and morphological data suggest that glucagon-related peptides may act as neurotransmitters or neuromodulators in the hypothalamus and may be involved in the central regulatory mechanism related to feeding behavior and energy metabolism.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Fasting</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucagon - immunology</subject><subject>Glucagon-Like Peptides</subject><subject>Hypothalamus - cytology</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Immune Sera</subject><subject>Immunoassay</subject><subject>Morphology. 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Psychology</topic><topic>Glucagon - immunology</topic><topic>Glucagon-Like Peptides</topic><topic>Hypothalamus - cytology</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Immune Sera</topic><topic>Immunoassay</topic><topic>Morphology. Functional localizations</topic><topic>Peptides - analysis</topic><topic>Radioimmunoassay - methods</topic><topic>Rats</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>INOKUCHI, A</creatorcontrib><creatorcontrib>TOMIDA, Y</creatorcontrib><creatorcontrib>YANAIHARA, C</creatorcontrib><creatorcontrib>YUI, R</creatorcontrib><creatorcontrib>OOMURA, Y</creatorcontrib><creatorcontrib>KIMURA, H</creatorcontrib><creatorcontrib>HASE, T</creatorcontrib><creatorcontrib>MATSUMOTO, T</creatorcontrib><creatorcontrib>YANAIHARA, N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell and tissue research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>INOKUCHI, A</au><au>TOMIDA, Y</au><au>YANAIHARA, C</au><au>YUI, R</au><au>OOMURA, Y</au><au>KIMURA, H</au><au>HASE, T</au><au>MATSUMOTO, T</au><au>YANAIHARA, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glucagon-related peptides in the rat hypothalamus</atitle><jtitle>Cell and tissue research</jtitle><addtitle>Cell Tissue Res</addtitle><date>1986-01-01</date><risdate>1986</risdate><volume>246</volume><issue>1</issue><spage>71</spage><epage>75</epage><pages>71-75</pages><issn>0302-766X</issn><eissn>1432-0878</eissn><coden>CTSRCS</coden><abstract>Immunohistochemically, nerve fibers and terminals reacting with anti-N-terminal-specific but not with anti-C-terminal-specific glucagon antiserum were observed in the following rat hypothalamic regions: paraventricular nucleus, supraoptic nucleus, anterior hypothalamus, arcuate nucleus, ventromedial hypothalamic nucleus and median eminence. Few fibers and terminals were demonstrated in the lateral hypothalamic area and dorsomedial hypothalamic nucleus. Radioimmunoassay data indicated that the concentration of gut glucagon-like immunoreactivity was higher in the ventromedial nucleus than in the lateral hypothalamic area. In food-deprived conditions, this concentration increased in both these parts. This was also verified in immunostained preparations in which a marked enhancement of gut glucagon-like immunoreactivity-containing fibers and terminals was observed in many hypothalamic regions. Several immunoreactive cell bodies were found in the ventromedial and arcuate nuclei of starved rats. Both biochemical and morphological data suggest that glucagon-related peptides may act as neurotransmitters or neuromodulators in the hypothalamus and may be involved in the central regulatory mechanism related to feeding behavior and energy metabolism.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>3779802</pmid><doi>10.1007/BF00219001</doi><tpages>5</tpages></addata></record> |
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| ispartof | Cell and tissue research, 1986-01, Vol.246 (1), p.71-75 |
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| subjects | Animals Biological and medical sciences Fasting Fundamental and applied biological sciences. Psychology Glucagon - immunology Glucagon-Like Peptides Hypothalamus - cytology Hypothalamus. Hypophysis. Epiphysis. Urophysis Immune Sera Immunoassay Morphology. Functional localizations Peptides - analysis Radioimmunoassay - methods Rats Vertebrates: endocrinology |
| title | Glucagon-related peptides in the rat hypothalamus |
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