Meta-iodobenzylguanidine inhibits complex I and III of the respiratory chain in the human cell line molt-4

In this paper we report the effects of meta-iodobenzylguanidine (MIBG), a structural analogue of norepinephrine, on cell proliferation and several parameters related to mitochondrial respiration in Molt-4 cells. In micromolar concentrations, MIBG completely inhibited the proliferation of Molt-4 cell...

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Veröffentlicht in:	Biochemical pharmacology 1995-02, Vol.49 (4), p.471-477
Hauptverfasser:	Cornelissen, Jan, Wanders, Ronald J.A., van Gennip, Albert H., van den Bogert, Coby, Voûte, P.A., van Kuilenburg, AndréB.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Iodobenzylguanidine Adenosine Triphosphate - biosynthesis Antineoplastic agents ATP synthesis Biological and medical sciences Cell Division - drug effects cell proliferation Culture Media Electron Transport Complex III - antagonists & inhibitors enzyme inhibition General aspects Humans Iodobenzenes - pharmacology Lactates - analysis Lactic Acid Medical sciences meta-iodobenzylguanidine Molt-4 NAD(P)H Dehydrogenase (Quinone) - antagonists & inhibitors Pharmacology. Drug treatments Pyruvates - analysis Pyruvic Acid respiratory chain Tumor Cells, Cultured
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