Urinary enzyme excretion after a single dose of phenacetin and paracetamol (acetaminophen) during antidiuresis and during water diuresis
2 g phenacetin or paracetamol in a single oral dose were administered to five healthy persons under the conditions of antidiuresis and subsequent water diuresis. Excretion of the brush border enzyme GGT, the cytoplasm enzyme LDH, and the lysosomal enzymes, NAG and GAL, was analysed before, during an...
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| Veröffentlicht in: | Clinica chimica acta 1986-10, Vol.160 (2), p.151-155 |
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| container_title | Clinica chimica acta |
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| creator | Metz, Ulrike Graben, Nikolaus Maruhn, Dieter Bock, Klaus Dietrich |
| description | 2 g phenacetin or paracetamol in a single oral dose were administered to five healthy persons under the conditions of antidiuresis and subsequent water diuresis. Excretion of the brush border enzyme GGT, the cytoplasm enzyme LDH, and the lysosomal enzymes, NAG and GAL, was analysed before, during and after ingestion of the analgesics. Increased excretion of LDH and GGT indicated a similar moderate damage of the tubular epithelia after phenacetin and paracetamol. The state of diuresis appeared to have no influence. |
| doi_str_mv | 10.1016/0009-8981(86)90136-1 |
| format | Article |
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Excretion of the brush border enzyme GGT, the cytoplasm enzyme LDH, and the lysosomal enzymes, NAG and GAL, was analysed before, during and after ingestion of the analgesics. Increased excretion of LDH and GGT indicated a similar moderate damage of the tubular epithelia after phenacetin and paracetamol. The state of diuresis appeared to have no influence.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/0009-8981(86)90136-1</identifier><identifier>PMID: 2877759</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acetaminophen - pharmacology ; Acetylglucosaminidase - urine ; Antidiuresis ; beta-Galactosidase - urine ; Diuresis ; Enzymes - urine ; gamma-Glutamyltransferase - urine ; Humans ; Kidney - drug effects ; Kidney - enzymology ; L-Lactate Dehydrogenase - urine ; Leucyl Aminopeptidase - urine ; Paracetamol ; Phenacetin ; Phenacetin - pharmacology ; Random Allocation ; Urinary enzymes ; Water - metabolism ; Water diuresis</subject><ispartof>Clinica chimica acta, 1986-10, Vol.160 (2), p.151-155</ispartof><rights>1986</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-87247184b1dc59fa7f684ebeaad96d040be25020da689e3835e577b053f7e84d3</citedby><cites>FETCH-LOGICAL-c357t-87247184b1dc59fa7f684ebeaad96d040be25020da689e3835e577b053f7e84d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0009898186901361$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2877759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Metz, Ulrike</creatorcontrib><creatorcontrib>Graben, Nikolaus</creatorcontrib><creatorcontrib>Maruhn, Dieter</creatorcontrib><creatorcontrib>Bock, Klaus Dietrich</creatorcontrib><title>Urinary enzyme excretion after a single dose of phenacetin and paracetamol (acetaminophen) during antidiuresis and during water diuresis</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>2 g phenacetin or paracetamol in a single oral dose were administered to five healthy persons under the conditions of antidiuresis and subsequent water diuresis. Excretion of the brush border enzyme GGT, the cytoplasm enzyme LDH, and the lysosomal enzymes, NAG and GAL, was analysed before, during and after ingestion of the analgesics. Increased excretion of LDH and GGT indicated a similar moderate damage of the tubular epithelia after phenacetin and paracetamol. The state of diuresis appeared to have no influence.</description><subject>Acetaminophen - pharmacology</subject><subject>Acetylglucosaminidase - urine</subject><subject>Antidiuresis</subject><subject>beta-Galactosidase - urine</subject><subject>Diuresis</subject><subject>Enzymes - urine</subject><subject>gamma-Glutamyltransferase - urine</subject><subject>Humans</subject><subject>Kidney - drug effects</subject><subject>Kidney - enzymology</subject><subject>L-Lactate Dehydrogenase - urine</subject><subject>Leucyl Aminopeptidase - urine</subject><subject>Paracetamol</subject><subject>Phenacetin</subject><subject>Phenacetin - pharmacology</subject><subject>Random Allocation</subject><subject>Urinary enzymes</subject><subject>Water - metabolism</subject><subject>Water diuresis</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctOxSAQhonR6PHyBpqwMrqoQlsK3ZiYE2-JiRtdEwpTxbRwhNbbE_jYUs_RpSuYmW_-yfyD0D4lJ5TQ6pQQUmeiFvRIVMc1oUWV0TU0o4IXWVHW-Tqa_SFbaDvG5xSWpKKbaDMXnHNWz9DXQ7BOhQ8M7vOjBwzvOsBgvcOqHSBghaN1jx1g4yNg3-LFEzilE5IIZ_BChSlSve_w0fJnnZ-gY2zGpP2YsMEaOwaINv70rPJvahrwW9lFG63qIuyt3h30cHlxP7_Obu-ububnt5kuGB8ywfOSU1E21GhWt4q3lSihAaVMXZm0XgM5IzkxqhI1FKJgwDhvCCtaDqI0xQ46XOougn8ZIQ6yt1FD1ykHfoySc8pYnucJLJegDj7GAK1cBNsnqyQlcjqAnNyVk7tSVPLnAJKmtoOV_tj0YP6aVo6n-tmyDmnJVwtBRm3BaTA2gB6k8fb_Ad9V4pev</recordid><startdate>19861031</startdate><enddate>19861031</enddate><creator>Metz, Ulrike</creator><creator>Graben, Nikolaus</creator><creator>Maruhn, Dieter</creator><creator>Bock, Klaus Dietrich</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19861031</creationdate><title>Urinary enzyme excretion after a single dose of phenacetin and paracetamol (acetaminophen) during antidiuresis and during water diuresis</title><author>Metz, Ulrike ; Graben, Nikolaus ; Maruhn, Dieter ; Bock, Klaus Dietrich</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-87247184b1dc59fa7f684ebeaad96d040be25020da689e3835e577b053f7e84d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Acetaminophen - pharmacology</topic><topic>Acetylglucosaminidase - urine</topic><topic>Antidiuresis</topic><topic>beta-Galactosidase - urine</topic><topic>Diuresis</topic><topic>Enzymes - urine</topic><topic>gamma-Glutamyltransferase - urine</topic><topic>Humans</topic><topic>Kidney - drug effects</topic><topic>Kidney - enzymology</topic><topic>L-Lactate Dehydrogenase - urine</topic><topic>Leucyl Aminopeptidase - urine</topic><topic>Paracetamol</topic><topic>Phenacetin</topic><topic>Phenacetin - pharmacology</topic><topic>Random Allocation</topic><topic>Urinary enzymes</topic><topic>Water - metabolism</topic><topic>Water diuresis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Metz, Ulrike</creatorcontrib><creatorcontrib>Graben, Nikolaus</creatorcontrib><creatorcontrib>Maruhn, Dieter</creatorcontrib><creatorcontrib>Bock, Klaus Dietrich</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Metz, Ulrike</au><au>Graben, Nikolaus</au><au>Maruhn, Dieter</au><au>Bock, Klaus Dietrich</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary enzyme excretion after a single dose of phenacetin and paracetamol (acetaminophen) during antidiuresis and during water diuresis</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>1986-10-31</date><risdate>1986</risdate><volume>160</volume><issue>2</issue><spage>151</spage><epage>155</epage><pages>151-155</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>2 g phenacetin or paracetamol in a single oral dose were administered to five healthy persons under the conditions of antidiuresis and subsequent water diuresis. Excretion of the brush border enzyme GGT, the cytoplasm enzyme LDH, and the lysosomal enzymes, NAG and GAL, was analysed before, during and after ingestion of the analgesics. Increased excretion of LDH and GGT indicated a similar moderate damage of the tubular epithelia after phenacetin and paracetamol. The state of diuresis appeared to have no influence.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>2877759</pmid><doi>10.1016/0009-8981(86)90136-1</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-8981 |
| ispartof | Clinica chimica acta, 1986-10, Vol.160 (2), p.151-155 |
| issn | 0009-8981 1873-3492 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77155222 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetaminophen - pharmacology Acetylglucosaminidase - urine Antidiuresis beta-Galactosidase - urine Diuresis Enzymes - urine gamma-Glutamyltransferase - urine Humans Kidney - drug effects Kidney - enzymology L-Lactate Dehydrogenase - urine Leucyl Aminopeptidase - urine Paracetamol Phenacetin Phenacetin - pharmacology Random Allocation Urinary enzymes Water - metabolism Water diuresis |
| title | Urinary enzyme excretion after a single dose of phenacetin and paracetamol (acetaminophen) during antidiuresis and during water diuresis |
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