angiogenic activity of anterior pituitary tissue and growth hormone on the chick embryo chorio-allantoic membrane : A novel action of GH
A useful system to evaluate the angiogenic activity of hormones and growth factors is the chorioallantoic membrane (CAM) of chick embryos. The present studies examined the angiogenic activity of chicken anterior pituitary glands and both fibroblast growth factor (FGF) and growth hormone (GH). Grafts...
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| Veröffentlicht in: | Life sciences (1973) 1995, Vol.56 (8), p.587-594 |
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| container_title | Life sciences (1973) |
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| creator | Gould, Janet Aramburo, Carlos Capdevielle, Marie Scanes, Colin G. |
| description | A useful system to evaluate the angiogenic activity of hormones and growth factors is the chorioallantoic membrane (CAM) of chick embryos. The present studies examined the angiogenic activity of chicken anterior pituitary glands and both fibroblast growth factor (FGF) and growth hormone (GH). Grafts of anterior pituitary gland evoked an angiogenic response on the CAM which was lost if the adenohypophyseal tissue was first boiled. The magnitude of the angiogenic response to anterior pituitary glands increased with the age of the donor (from a minimum 15 days of embryonic development to a maximum between 2 and 6 weeks old). In view of the similarity of the profile of the angiogenic response and the reported changes in GH secretion, the angiogenic activity of GH was then examined. Considerable angiogenic responses were observed with GH; there being increases (P < 0.05) in number of new blood vessels on the CAM of chick embryos on which native chicken GH or native bovine GH or recombinant bovine GH were added. These data support GH having an angiogenic action. |
| doi_str_mv | 10.1016/0024-3205(94)00491-A |
| format | Article |
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The present studies examined the angiogenic activity of chicken anterior pituitary glands and both fibroblast growth factor (FGF) and growth hormone (GH). Grafts of anterior pituitary gland evoked an angiogenic response on the CAM which was lost if the adenohypophyseal tissue was first boiled. The magnitude of the angiogenic response to anterior pituitary glands increased with the age of the donor (from a minimum 15 days of embryonic development to a maximum between 2 and 6 weeks old). In view of the similarity of the profile of the angiogenic response and the reported changes in GH secretion, the angiogenic activity of GH was then examined. Considerable angiogenic responses were observed with GH; there being increases (P < 0.05) in number of new blood vessels on the CAM of chick embryos on which native chicken GH or native bovine GH or recombinant bovine GH were added. These data support GH having an angiogenic action.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(94)00491-A</identifier><identifier>PMID: 7532777</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Allantois - blood supply ; angiogenesis ; Angiogenesis Inducing Agents - pharmacology ; Animals ; Chick Embryo ; chorio-allantoic membrane estrogen ; Chorion - blood supply ; Epidermal Growth Factor - pharmacology ; growth hormone ; Growth Hormone - pharmacology ; Insulin-Like Growth Factor I - physiology ; Neovascularization, Pathologic ; Pituitary Gland, Anterior - physiology</subject><ispartof>Life sciences (1973), 1995, Vol.56 (8), p.587-594</ispartof><rights>1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c272t-d5f46a80363c09e1a8de4ee9b19df82b63e091905d454594356b9f3414cf35863</citedby><cites>FETCH-LOGICAL-c272t-d5f46a80363c09e1a8de4ee9b19df82b63e091905d454594356b9f3414cf35863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/002432059400491A$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7532777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gould, Janet</creatorcontrib><creatorcontrib>Aramburo, Carlos</creatorcontrib><creatorcontrib>Capdevielle, Marie</creatorcontrib><creatorcontrib>Scanes, Colin G.</creatorcontrib><title>angiogenic activity of anterior pituitary tissue and growth hormone on the chick embryo chorio-allantoic membrane : A novel action of GH</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>A useful system to evaluate the angiogenic activity of hormones and growth factors is the chorioallantoic membrane (CAM) of chick embryos. The present studies examined the angiogenic activity of chicken anterior pituitary glands and both fibroblast growth factor (FGF) and growth hormone (GH). Grafts of anterior pituitary gland evoked an angiogenic response on the CAM which was lost if the adenohypophyseal tissue was first boiled. The magnitude of the angiogenic response to anterior pituitary glands increased with the age of the donor (from a minimum 15 days of embryonic development to a maximum between 2 and 6 weeks old). In view of the similarity of the profile of the angiogenic response and the reported changes in GH secretion, the angiogenic activity of GH was then examined. Considerable angiogenic responses were observed with GH; there being increases (P < 0.05) in number of new blood vessels on the CAM of chick embryos on which native chicken GH or native bovine GH or recombinant bovine GH were added. These data support GH having an angiogenic action.</description><subject>Allantois - blood supply</subject><subject>angiogenesis</subject><subject>Angiogenesis Inducing Agents - pharmacology</subject><subject>Animals</subject><subject>Chick Embryo</subject><subject>chorio-allantoic membrane estrogen</subject><subject>Chorion - blood supply</subject><subject>Epidermal Growth Factor - pharmacology</subject><subject>growth hormone</subject><subject>Growth Hormone - pharmacology</subject><subject>Insulin-Like Growth Factor I - physiology</subject><subject>Neovascularization, Pathologic</subject><subject>Pituitary Gland, Anterior - physiology</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uc1u1DAQthCobAtvAJJPiB4C49iOYw6VVhW0SJW4wNlynMmuYRMvtrNo34DHxumueuQ0Gn1_9jeEvGHwgQFrPgLUouI1yPdaXAMIzar1M7JirdIVNJw9J6snyktymdJPAJBS8QtyoSSvlVIr8tdOGx82OHlHrcv-4PORhoHaKWP0IdK9z7PPNh5p9inNWJCebmL4k7d0G-IYJqRhonmL1G29-0Vx7OIxlCUUfWV3u2IVivu4ALawP9E1ncIBd4-BRVvi7u5fkReD3SV8fZ5X5MeXz99v76uHb3dfb9cPlatVnateDqKxLfCGO9DIbNujQNQd0_3Q1l3DETTTIHshhdSCy6bTAxdMuIHLtuFX5N3Jdx_D7xlTNqNPDpdnYpiTUYpJCbUuRHEiuhhSijiYffRjKcIwMMsBzNKuWdo1WpjHA5h1kb09-8_diP2T6Nx4wW9OOJZPHjxGk5zHyWHvI7ps-uD_H_APyAyWAw</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Gould, Janet</creator><creator>Aramburo, Carlos</creator><creator>Capdevielle, Marie</creator><creator>Scanes, Colin G.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>angiogenic activity of anterior pituitary tissue and growth hormone on the chick embryo chorio-allantoic membrane : A novel action of GH</title><author>Gould, Janet ; Aramburo, Carlos ; Capdevielle, Marie ; Scanes, Colin G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-d5f46a80363c09e1a8de4ee9b19df82b63e091905d454594356b9f3414cf35863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Allantois - blood supply</topic><topic>angiogenesis</topic><topic>Angiogenesis Inducing Agents - pharmacology</topic><topic>Animals</topic><topic>Chick Embryo</topic><topic>chorio-allantoic membrane estrogen</topic><topic>Chorion - blood supply</topic><topic>Epidermal Growth Factor - pharmacology</topic><topic>growth hormone</topic><topic>Growth Hormone - pharmacology</topic><topic>Insulin-Like Growth Factor I - physiology</topic><topic>Neovascularization, Pathologic</topic><topic>Pituitary Gland, Anterior - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gould, Janet</creatorcontrib><creatorcontrib>Aramburo, Carlos</creatorcontrib><creatorcontrib>Capdevielle, Marie</creatorcontrib><creatorcontrib>Scanes, Colin G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gould, Janet</au><au>Aramburo, Carlos</au><au>Capdevielle, Marie</au><au>Scanes, Colin G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>angiogenic activity of anterior pituitary tissue and growth hormone on the chick embryo chorio-allantoic membrane : A novel action of GH</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1995</date><risdate>1995</risdate><volume>56</volume><issue>8</issue><spage>587</spage><epage>594</epage><pages>587-594</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>A useful system to evaluate the angiogenic activity of hormones and growth factors is the chorioallantoic membrane (CAM) of chick embryos. The present studies examined the angiogenic activity of chicken anterior pituitary glands and both fibroblast growth factor (FGF) and growth hormone (GH). Grafts of anterior pituitary gland evoked an angiogenic response on the CAM which was lost if the adenohypophyseal tissue was first boiled. The magnitude of the angiogenic response to anterior pituitary glands increased with the age of the donor (from a minimum 15 days of embryonic development to a maximum between 2 and 6 weeks old). In view of the similarity of the profile of the angiogenic response and the reported changes in GH secretion, the angiogenic activity of GH was then examined. Considerable angiogenic responses were observed with GH; there being increases (P < 0.05) in number of new blood vessels on the CAM of chick embryos on which native chicken GH or native bovine GH or recombinant bovine GH were added. These data support GH having an angiogenic action.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>7532777</pmid><doi>10.1016/0024-3205(94)00491-A</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 1995, Vol.56 (8), p.587-594 |
| issn | 0024-3205 1879-0631 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Allantois - blood supply angiogenesis Angiogenesis Inducing Agents - pharmacology Animals Chick Embryo chorio-allantoic membrane estrogen Chorion - blood supply Epidermal Growth Factor - pharmacology growth hormone Growth Hormone - pharmacology Insulin-Like Growth Factor I - physiology Neovascularization, Pathologic Pituitary Gland, Anterior - physiology |
| title | angiogenic activity of anterior pituitary tissue and growth hormone on the chick embryo chorio-allantoic membrane : A novel action of GH |
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