Human genetic defect in leukotriene C4 synthesis
Normal human platelets metabolise [3H]-LTA4 into [3H]-LTC4. Platelets from patients with glutathione synthetase deficiency possessing 10-30% of normal levels of cellular glutathione showed marked reduction in capacity to form [3H]-LTC4 (8-10% of normal) even though exogenous reduced glutathione was...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1986-11, Vol.140 (3), p.857-860 |
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| container_title | Biochemical and biophysical research communications |
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| creator | PACE-ASCIAK, C. R KLEIN, J SPIELBERG, S. P |
| description | Normal human platelets metabolise [3H]-LTA4 into [3H]-LTC4. Platelets from patients with glutathione synthetase deficiency possessing 10-30% of normal levels of cellular glutathione showed marked reduction in capacity to form [3H]-LTC4 (8-10% of normal) even though exogenous reduced glutathione was added to the incubation medium. To our knowledge this is the first demonstration of a genetic defect in LTC4 synthetase coupled to a defect in cellular glutathione levels. |
| doi_str_mv | 10.1016/0006-291X(86)90713-8 |
| format | Article |
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To our knowledge this is the first demonstration of a genetic defect in LTC4 synthetase coupled to a defect in cellular glutathione levels.</description><subject>Applied sciences</subject><subject>Arachidonic Acids - blood</subject><subject>Blood Platelets - enzymology</subject><subject>Child</subject><subject>Exact sciences and technology</subject><subject>Glutathione - metabolism</subject><subject>Glutathione Synthase - deficiency</subject><subject>Glutathione Synthase - genetics</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Leukotriene A4</subject><subject>Male</subject><subject>Metabolism, Inborn Errors - genetics</subject><subject>Other techniques and industries</subject><subject>SRS-A - biosynthesis</subject><subject>SRS-A - genetics</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLw0AUhQdRaq3-A4UsRHQRvfPInclSilqh4EbB3TCZ3Gg0D80ki_57Uxu6unDPd87iY-ycwy0HjncAgLFI-fu1wZsUNJexOWBzDinEgoM6ZPM9csxOQvgC4FxhOmMzCUJoqecMVkPtmuiDGupLH-VUkO-jsokqGr7bvivHIFqqKGya_pNCGU7ZUeGqQGfTXbC3x4fX5Spevzw9L-_XsRcK-zjVpFMg1B5yI1WBhQEkRBSJTnI0SSYzRE6QSeIuF06oRCaF48JzIcbvgl3tdn-69neg0Nu6DJ6qyjXUDsFqzRORIIyg2oG-a0PoqLA_XVm7bmM52K0ou7VgtxasQfsvypqxdjHtD1lN-b40mRnzyyl3wbuq6Fzjy7DHjMREjUt_InFuHQ</recordid><startdate>19861114</startdate><enddate>19861114</enddate><creator>PACE-ASCIAK, C. 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| fulltext | fulltext |
| identifier | ISSN: 0006-291X |
| ispartof | Biochemical and biophysical research communications, 1986-11, Vol.140 (3), p.857-860 |
| issn | 0006-291X 1090-2104 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77152560 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Applied sciences Arachidonic Acids - blood Blood Platelets - enzymology Child Exact sciences and technology Glutathione - metabolism Glutathione Synthase - deficiency Glutathione Synthase - genetics Humans In Vitro Techniques Leukotriene A4 Male Metabolism, Inborn Errors - genetics Other techniques and industries SRS-A - biosynthesis SRS-A - genetics |
| title | Human genetic defect in leukotriene C4 synthesis |
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