Induction of RET Proto-Oncogene Expression in Neuroblastoma Cells Precedes Neuronal Differentiation and Is Not Mediated by Protein Synthesis

RET proto-oncogene products are involved in neural crest development, and constitutional RET mutations are associated with syndromes characterized by tumors of neural crest origin. To study the regulation of RET transcription during neuronal differentiation we analyzed RET expression in neuroblastom...

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Veröffentlicht in:	Experimental cell research 1995-03, Vol.217 (1), p.92-99
Hauptverfasser:	Bunone, Giuseppe, Borrello, Maria G., Picetti, Roberto, Bongarzone, Italia, Peverali, Fiorenzo A., de Franciscis, Vittorio, Valle, Giuliano Della, Pierotti, Marco A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Differentiation - drug effects Cell Differentiation - physiology Cycloheximide - pharmacology Drosophila Proteins Gene Expression Regulation, Neoplastic - physiology Humans Neuroblastoma - metabolism Neuroblastoma - pathology Neurons - cytology Protein Synthesis Inhibitors - pharmacology Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-ret Receptor Protein-Tyrosine Kinases - biosynthesis Receptor Protein-Tyrosine Kinases - genetics RNA, Messenger - biosynthesis RNA, Neoplasm - biosynthesis Transcription, Genetic - drug effects Tretinoin - pharmacology Tumor Cells, Cultured
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