Effect of oral colchicine on T cell subsets, monocytes and concanavalin A-induced suppressor cell function in asthmatic patients
Summary Asthmatic patients have a deficiency of concanavalin A‐(Con A) induced suppressor cell function. We tested whether oral colchicine 0·5 mg twice daily for 7 days could correct this immunoregulatory abnormality. Peripheral blood mononuclear cells were incubated with Con A and then suppression...
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| Veröffentlicht in: | Clinical allergy 1986-09, Vol.16 (5), p.407-416 |
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| creator | ILFELD, D. N. MAZAR, A. GARTY, M. FINK, G. SPITZER, S. PECHT, M. NETZER, L. TRAININ, N. KUPERMAN, O. |
| description | Summary
Asthmatic patients have a deficiency of concanavalin A‐(Con A) induced suppressor cell function. We tested whether oral colchicine 0·5 mg twice daily for 7 days could correct this immunoregulatory abnormality. Peripheral blood mononuclear cells were incubated with Con A and then suppression of proliferation was measured by co‐culture of these cells with healthy volunteers’mononuclear cells and phytohaemagglutinin. Sixteen asthmatic patients had significantly (P < 0·002) decreased Con A‐induced suppressor cell function (17·0±17·2%, mean ± s.d.) as compared to 13 healthy volunteers (37·9±14·9%). Oral colchicine significantly (P < 0·05) increased, though only partially corrected, these 16 asthmatic patients’Con A‐induced suppressor cell function (28·1±14·3%). Asthmatic patients had an increased number of monocytes (691±289 vs 388±271/mm3 for normals, P < 0·01) and a normal number of lymphocytes, Leu 4+ total T cells, Leu 3+ helper/inducer T cells, and Leu 2+ suppressor/cytotoxic T cells as well as a normal Leu 3/Leu 2 ratio. Oral colchicine significantly (P < 0·005) decreased the number of monocytes (451±255/mm3) without significantly affecting the number of lymphocytes, Leu 4+, Leu 3+, or Leu 2+ T cells, or the Leu 3/Leu 2 ratio. These results are consistent with the hypothesis that the deficiency of Con A‐induced suppressor cell function in asthmatic patients may be due, in part, to an increased number and/or abnormal activity of monocytes. If so, then oral colchicine may have partially corrected the deficiency of Con A‐induced suppressor cell function by decreasing the number and/or modulating the activity of monocytes. |
| doi_str_mv | 10.1111/j.1365-2222.1986.tb01975.x |
| format | Article |
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Asthmatic patients have a deficiency of concanavalin A‐(Con A) induced suppressor cell function. We tested whether oral colchicine 0·5 mg twice daily for 7 days could correct this immunoregulatory abnormality. Peripheral blood mononuclear cells were incubated with Con A and then suppression of proliferation was measured by co‐culture of these cells with healthy volunteers’mononuclear cells and phytohaemagglutinin. Sixteen asthmatic patients had significantly (P < 0·002) decreased Con A‐induced suppressor cell function (17·0±17·2%, mean ± s.d.) as compared to 13 healthy volunteers (37·9±14·9%). Oral colchicine significantly (P < 0·05) increased, though only partially corrected, these 16 asthmatic patients’Con A‐induced suppressor cell function (28·1±14·3%). Asthmatic patients had an increased number of monocytes (691±289 vs 388±271/mm3 for normals, P < 0·01) and a normal number of lymphocytes, Leu 4+ total T cells, Leu 3+ helper/inducer T cells, and Leu 2+ suppressor/cytotoxic T cells as well as a normal Leu 3/Leu 2 ratio. Oral colchicine significantly (P < 0·005) decreased the number of monocytes (451±255/mm3) without significantly affecting the number of lymphocytes, Leu 4+, Leu 3+, or Leu 2+ T cells, or the Leu 3/Leu 2 ratio. These results are consistent with the hypothesis that the deficiency of Con A‐induced suppressor cell function in asthmatic patients may be due, in part, to an increased number and/or abnormal activity of monocytes. If so, then oral colchicine may have partially corrected the deficiency of Con A‐induced suppressor cell function by decreasing the number and/or modulating the activity of monocytes.</description><identifier>ISSN: 0954-7894</identifier><identifier>ISSN: 0009-9090</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1111/j.1365-2222.1986.tb01975.x</identifier><identifier>PMID: 2877755</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Asthma - blood ; Asthma - drug therapy ; Asthma - immunology ; Biological and medical sciences ; Colchicine - therapeutic use ; Concanavalin A - pharmacology ; Cyclic AMP - blood ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Monocytes - drug effects ; Monocytes - immunology ; Pharmacology. Drug treatments ; Respiratory system ; T-Lymphocytes - drug effects ; T-Lymphocytes - immunology ; T-Lymphocytes, Regulatory - drug effects ; T-Lymphocytes, Regulatory - immunology</subject><ispartof>Clinical allergy, 1986-09, Vol.16 (5), p.407-416</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5067-180139ef23d9957d87a8b6071e01dac009133ba184ad87d680bc1d44f66cfc6c3</citedby><cites>FETCH-LOGICAL-c5067-180139ef23d9957d87a8b6071e01dac009133ba184ad87d680bc1d44f66cfc6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2222.1986.tb01975.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2222.1986.tb01975.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7922199$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2877755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ILFELD, D. N.</creatorcontrib><creatorcontrib>MAZAR, A.</creatorcontrib><creatorcontrib>GARTY, M.</creatorcontrib><creatorcontrib>FINK, G.</creatorcontrib><creatorcontrib>SPITZER, S.</creatorcontrib><creatorcontrib>PECHT, M.</creatorcontrib><creatorcontrib>NETZER, L.</creatorcontrib><creatorcontrib>TRAININ, N.</creatorcontrib><creatorcontrib>KUPERMAN, O.</creatorcontrib><title>Effect of oral colchicine on T cell subsets, monocytes and concanavalin A-induced suppressor cell function in asthmatic patients</title><title>Clinical allergy</title><addtitle>Clin Allergy</addtitle><description>Summary
Asthmatic patients have a deficiency of concanavalin A‐(Con A) induced suppressor cell function. We tested whether oral colchicine 0·5 mg twice daily for 7 days could correct this immunoregulatory abnormality. Peripheral blood mononuclear cells were incubated with Con A and then suppression of proliferation was measured by co‐culture of these cells with healthy volunteers’mononuclear cells and phytohaemagglutinin. Sixteen asthmatic patients had significantly (P < 0·002) decreased Con A‐induced suppressor cell function (17·0±17·2%, mean ± s.d.) as compared to 13 healthy volunteers (37·9±14·9%). Oral colchicine significantly (P < 0·05) increased, though only partially corrected, these 16 asthmatic patients’Con A‐induced suppressor cell function (28·1±14·3%). Asthmatic patients had an increased number of monocytes (691±289 vs 388±271/mm3 for normals, P < 0·01) and a normal number of lymphocytes, Leu 4+ total T cells, Leu 3+ helper/inducer T cells, and Leu 2+ suppressor/cytotoxic T cells as well as a normal Leu 3/Leu 2 ratio. Oral colchicine significantly (P < 0·005) decreased the number of monocytes (451±255/mm3) without significantly affecting the number of lymphocytes, Leu 4+, Leu 3+, or Leu 2+ T cells, or the Leu 3/Leu 2 ratio. These results are consistent with the hypothesis that the deficiency of Con A‐induced suppressor cell function in asthmatic patients may be due, in part, to an increased number and/or abnormal activity of monocytes. If so, then oral colchicine may have partially corrected the deficiency of Con A‐induced suppressor cell function by decreasing the number and/or modulating the activity of monocytes.</description><subject>Adult</subject><subject>Asthma - blood</subject><subject>Asthma - drug therapy</subject><subject>Asthma - immunology</subject><subject>Biological and medical sciences</subject><subject>Colchicine - therapeutic use</subject><subject>Concanavalin A - pharmacology</subject><subject>Cyclic AMP - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Monocytes - drug effects</subject><subject>Monocytes - immunology</subject><subject>Pharmacology. Drug treatments</subject><subject>Respiratory system</subject><subject>T-Lymphocytes - drug effects</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes, Regulatory - drug effects</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><issn>0954-7894</issn><issn>0009-9090</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF-L1DAUxYMo6-zqRxCCiE-2Jv2TND4IwzC7KyyKsLq-hTRN2IxtUpNUZ9786Ka0zLv3IXk4v3Pu5QDwGqMcp3l_yHFJ6qxIk2PWkDy2CDNa58cnYHOWnoINYnWV0YZVz8FlCAeEUFmz5gJcFA2ltK434O9eayUjdBo6L3ooXS8fjTRWQWfhPZSq72GY2qBieAcHZ508RRWgsF1irRRW_Ba9sXCbGdtNUnWJHkevQnB-cevJymhSWqJEiI-DiEbCMb3KxvACPNOiD-rl-l-Bb9f7-91tdvfl5tNue5fJGhGa4QbhkildlB1jNe0aKpqWIIoVwp2QCDFclq3ATSWS1pEGtRJ3VaUJkVoSWV6Bt0vu6N2vSYXIBxPm-4RVbgqcUlxjWqAEflhA6V0IXmk-ejMIf-IY8bl-fuBzx3zumM_187V-fkzmV-uWqR1Ud7aufSf9zaqLIEWvvbDShDNGWVFgxhL2ccH-mF6d_uMAvttvK0RTQLYEmBDV8Rwg_E9OaJnIh883nBD64_vD7VdOyn-MRbKw</recordid><startdate>198609</startdate><enddate>198609</enddate><creator>ILFELD, D. N.</creator><creator>MAZAR, A.</creator><creator>GARTY, M.</creator><creator>FINK, G.</creator><creator>SPITZER, S.</creator><creator>PECHT, M.</creator><creator>NETZER, L.</creator><creator>TRAININ, N.</creator><creator>KUPERMAN, O.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198609</creationdate><title>Effect of oral colchicine on T cell subsets, monocytes and concanavalin A-induced suppressor cell function in asthmatic patients</title><author>ILFELD, D. N. ; MAZAR, A. ; GARTY, M. ; FINK, G. ; SPITZER, S. ; PECHT, M. ; NETZER, L. ; TRAININ, N. ; KUPERMAN, O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5067-180139ef23d9957d87a8b6071e01dac009133ba184ad87d680bc1d44f66cfc6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Asthma - blood</topic><topic>Asthma - drug therapy</topic><topic>Asthma - immunology</topic><topic>Biological and medical sciences</topic><topic>Colchicine - therapeutic use</topic><topic>Concanavalin A - pharmacology</topic><topic>Cyclic AMP - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Monocytes - drug effects</topic><topic>Monocytes - immunology</topic><topic>Pharmacology. Drug treatments</topic><topic>Respiratory system</topic><topic>T-Lymphocytes - drug effects</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes, Regulatory - drug effects</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ILFELD, D. N.</creatorcontrib><creatorcontrib>MAZAR, A.</creatorcontrib><creatorcontrib>GARTY, M.</creatorcontrib><creatorcontrib>FINK, G.</creatorcontrib><creatorcontrib>SPITZER, S.</creatorcontrib><creatorcontrib>PECHT, M.</creatorcontrib><creatorcontrib>NETZER, L.</creatorcontrib><creatorcontrib>TRAININ, N.</creatorcontrib><creatorcontrib>KUPERMAN, O.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ILFELD, D. N.</au><au>MAZAR, A.</au><au>GARTY, M.</au><au>FINK, G.</au><au>SPITZER, S.</au><au>PECHT, M.</au><au>NETZER, L.</au><au>TRAININ, N.</au><au>KUPERMAN, O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of oral colchicine on T cell subsets, monocytes and concanavalin A-induced suppressor cell function in asthmatic patients</atitle><jtitle>Clinical allergy</jtitle><addtitle>Clin Allergy</addtitle><date>1986-09</date><risdate>1986</risdate><volume>16</volume><issue>5</issue><spage>407</spage><epage>416</epage><pages>407-416</pages><issn>0954-7894</issn><issn>0009-9090</issn><eissn>1365-2222</eissn><abstract>Summary
Asthmatic patients have a deficiency of concanavalin A‐(Con A) induced suppressor cell function. We tested whether oral colchicine 0·5 mg twice daily for 7 days could correct this immunoregulatory abnormality. Peripheral blood mononuclear cells were incubated with Con A and then suppression of proliferation was measured by co‐culture of these cells with healthy volunteers’mononuclear cells and phytohaemagglutinin. Sixteen asthmatic patients had significantly (P < 0·002) decreased Con A‐induced suppressor cell function (17·0±17·2%, mean ± s.d.) as compared to 13 healthy volunteers (37·9±14·9%). Oral colchicine significantly (P < 0·05) increased, though only partially corrected, these 16 asthmatic patients’Con A‐induced suppressor cell function (28·1±14·3%). Asthmatic patients had an increased number of monocytes (691±289 vs 388±271/mm3 for normals, P < 0·01) and a normal number of lymphocytes, Leu 4+ total T cells, Leu 3+ helper/inducer T cells, and Leu 2+ suppressor/cytotoxic T cells as well as a normal Leu 3/Leu 2 ratio. Oral colchicine significantly (P < 0·005) decreased the number of monocytes (451±255/mm3) without significantly affecting the number of lymphocytes, Leu 4+, Leu 3+, or Leu 2+ T cells, or the Leu 3/Leu 2 ratio. These results are consistent with the hypothesis that the deficiency of Con A‐induced suppressor cell function in asthmatic patients may be due, in part, to an increased number and/or abnormal activity of monocytes. If so, then oral colchicine may have partially corrected the deficiency of Con A‐induced suppressor cell function by decreasing the number and/or modulating the activity of monocytes.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2877755</pmid><doi>10.1111/j.1365-2222.1986.tb01975.x</doi><tpages>10</tpages></addata></record> |
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| ispartof | Clinical allergy, 1986-09, Vol.16 (5), p.407-416 |
| issn | 0954-7894 0009-9090 1365-2222 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Adult Asthma - blood Asthma - drug therapy Asthma - immunology Biological and medical sciences Colchicine - therapeutic use Concanavalin A - pharmacology Cyclic AMP - blood Female Humans Male Medical sciences Middle Aged Monocytes - drug effects Monocytes - immunology Pharmacology. Drug treatments Respiratory system T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology |
| title | Effect of oral colchicine on T cell subsets, monocytes and concanavalin A-induced suppressor cell function in asthmatic patients |
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