Targeting expression of a dominant-negative retinoic acid receptor mutant in the epidermis of transgenic mice results in loss of barrier function

To study the effects of retinoic acid on the skin in vivo, we have subverted the activity of endogenous receptors by targeting expression of a dominant negative mutant of retinoic acid receptor alpha (RAR alpha) to the epidermis of transgenic mice. At birth, mice expressing the mutant RAR alpha tran...

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Veröffentlicht in:	Genes & development 1995-02, Vol.9 (3), p.317-329
Hauptverfasser:	Imakado, S, Bickenbach, J R, Bundman, D S, Rothnagel, J A, Attar, P S, Wang, X J, Walczak, V R, Wisniewski, S, Pote, J, Gordon, J S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Cells, Cultured Keratinocytes - metabolism Lipid Metabolism Mice Mice, Transgenic - metabolism Molecular Sequence Data Mutation Receptors, Retinoic Acid - biosynthesis Receptors, Retinoic Acid - genetics Skin - metabolism Skin - pathology Skin - ultrastructure Water - metabolism
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