Mammosomatotroph adenoma of the pituitary associated with gigantism and hyperprolactinemia. A morphological study including immunoelectron microscopy
A 29-year old giantess with growth hormone excess and hyperprolactinemia underwent transsphenoidal surgery to remove her pituitary tumor. Electron microscopy revealed a mammosomatotroph adenoma composed of one cell type. Immunoelectron microscopy, using the immunogold technique, demonstrated predomi...
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| Veröffentlicht in: | Acta neuropathologica 1986-01, Vol.71 (1-2), p.76-82 |
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| container_title | Acta neuropathologica |
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| creator | Felix, I A Horvath, E Kovacs, K Smyth, H S Killinger, D W Vale, J |
| description | A 29-year old giantess with growth hormone excess and hyperprolactinemia underwent transsphenoidal surgery to remove her pituitary tumor. Electron microscopy revealed a mammosomatotroph adenoma composed of one cell type. Immunoelectron microscopy, using the immunogold technique, demonstrated predominantly growth hormone or prolactin or a varying mixture of both growth hormone and prolactin in the adenoma cells. The presence of growth hormone and prolactin was found not only in the cytoplasm of the same adenoma cells but also in the same secretory granules. In the nontumorous adenohypophysis, somatotrophs and lactotrophs showed ultrastructural signs of hyperactivity. This finding is in contrast with the presence of suppressed somatotrophs and lactotrophs seen in nontumorous portions of adult pituitaries harboring growth hormone or prolactin-secreting adenomas. Our morphological study reinforces the view that growth hormone-producing pituitary tumors, originating in childhood, are different from those of the adult gland. |
| doi_str_mv | 10.1007/BF00687965 |
| format | Article |
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In the nontumorous adenohypophysis, somatotrophs and lactotrophs showed ultrastructural signs of hyperactivity. This finding is in contrast with the presence of suppressed somatotrophs and lactotrophs seen in nontumorous portions of adult pituitaries harboring growth hormone or prolactin-secreting adenomas. Our morphological study reinforces the view that growth hormone-producing pituitary tumors, originating in childhood, are different from those of the adult gland.</description><identifier>ISSN: 0001-6322</identifier><identifier>EISSN: 1432-0533</identifier><identifier>DOI: 10.1007/BF00687965</identifier><identifier>PMID: 3776476</identifier><language>eng</language><publisher>Germany</publisher><subject>Adenoma - complications ; Adenoma - metabolism ; Adenoma - ultrastructure ; Adult ; Female ; Gigantism - etiology ; Growth Hormone - metabolism ; Humans ; Hyperprolactinemia - etiology ; Microscopy, Electron ; Pituitary Neoplasms - complications ; Pituitary Neoplasms - metabolism ; Pituitary Neoplasms - ultrastructure ; Prolactin - metabolism</subject><ispartof>Acta neuropathologica, 1986-01, Vol.71 (1-2), p.76-82</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c282t-407e083c8a93c66b99becb982ade1f0b927cc4f9ca2a6bd8445c19960c1d8e13</citedby><cites>FETCH-LOGICAL-c282t-407e083c8a93c66b99becb982ade1f0b927cc4f9ca2a6bd8445c19960c1d8e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3776476$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Felix, I A</creatorcontrib><creatorcontrib>Horvath, E</creatorcontrib><creatorcontrib>Kovacs, K</creatorcontrib><creatorcontrib>Smyth, H S</creatorcontrib><creatorcontrib>Killinger, D W</creatorcontrib><creatorcontrib>Vale, J</creatorcontrib><title>Mammosomatotroph adenoma of the pituitary associated with gigantism and hyperprolactinemia. A morphological study including immunoelectron microscopy</title><title>Acta neuropathologica</title><addtitle>Acta Neuropathol</addtitle><description>A 29-year old giantess with growth hormone excess and hyperprolactinemia underwent transsphenoidal surgery to remove her pituitary tumor. Electron microscopy revealed a mammosomatotroph adenoma composed of one cell type. Immunoelectron microscopy, using the immunogold technique, demonstrated predominantly growth hormone or prolactin or a varying mixture of both growth hormone and prolactin in the adenoma cells. The presence of growth hormone and prolactin was found not only in the cytoplasm of the same adenoma cells but also in the same secretory granules. In the nontumorous adenohypophysis, somatotrophs and lactotrophs showed ultrastructural signs of hyperactivity. This finding is in contrast with the presence of suppressed somatotrophs and lactotrophs seen in nontumorous portions of adult pituitaries harboring growth hormone or prolactin-secreting adenomas. Our morphological study reinforces the view that growth hormone-producing pituitary tumors, originating in childhood, are different from those of the adult gland.</description><subject>Adenoma - complications</subject><subject>Adenoma - metabolism</subject><subject>Adenoma - ultrastructure</subject><subject>Adult</subject><subject>Female</subject><subject>Gigantism - etiology</subject><subject>Growth Hormone - metabolism</subject><subject>Humans</subject><subject>Hyperprolactinemia - etiology</subject><subject>Microscopy, Electron</subject><subject>Pituitary Neoplasms - complications</subject><subject>Pituitary Neoplasms - metabolism</subject><subject>Pituitary Neoplasms - ultrastructure</subject><subject>Prolactin - metabolism</subject><issn>0001-6322</issn><issn>1432-0533</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUtLxDAUhYMoOo5u3AtZuRCqebRJsxzFFyhuZl_S23QaaZLapMj8EP-vHRx0dTnwce659yB0QckNJUTe3j0SIkqpRHGAFjTnLCMF54doQQihmeCMnaDTGD9mxWReHKNjLqXIpVig7zftXIjB6RTSGIYO68b4WeLQ4tQZPNg02aTHLdYxBrA6mQZ_2dThjd1on2x0WPsGd9vBjMMYeg3JeuOsvsEr7MI4dKEPGwu6xzFNzRZbD_3UWL_B1rnJB9MbmFd77CyMIUIYtmfoqNV9NOf7uUTrx4f1_XP2-v70cr96zYCVLGU5kYaUHEqtOAhRK1UbqFXJ5htoS2rFJEDeKtBMi7op87wAqpQgQJvSUL5EV7-2c-7PycRUORvB9L32JkyxkpIWRAo2g9e_4C5gHE1bDaN181MqSqpdBdV_BTN8uXedameaP3T_c_4DN9yGSA</recordid><startdate>19860101</startdate><enddate>19860101</enddate><creator>Felix, I A</creator><creator>Horvath, E</creator><creator>Kovacs, K</creator><creator>Smyth, H S</creator><creator>Killinger, D W</creator><creator>Vale, J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860101</creationdate><title>Mammosomatotroph adenoma of the pituitary associated with gigantism and hyperprolactinemia. A morphological study including immunoelectron microscopy</title><author>Felix, I A ; Horvath, E ; Kovacs, K ; Smyth, H S ; Killinger, D W ; Vale, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-407e083c8a93c66b99becb982ade1f0b927cc4f9ca2a6bd8445c19960c1d8e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adenoma - complications</topic><topic>Adenoma - metabolism</topic><topic>Adenoma - ultrastructure</topic><topic>Adult</topic><topic>Female</topic><topic>Gigantism - etiology</topic><topic>Growth Hormone - metabolism</topic><topic>Humans</topic><topic>Hyperprolactinemia - etiology</topic><topic>Microscopy, Electron</topic><topic>Pituitary Neoplasms - complications</topic><topic>Pituitary Neoplasms - metabolism</topic><topic>Pituitary Neoplasms - ultrastructure</topic><topic>Prolactin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Felix, I A</creatorcontrib><creatorcontrib>Horvath, E</creatorcontrib><creatorcontrib>Kovacs, K</creatorcontrib><creatorcontrib>Smyth, H S</creatorcontrib><creatorcontrib>Killinger, D W</creatorcontrib><creatorcontrib>Vale, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neuropathologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Felix, I A</au><au>Horvath, E</au><au>Kovacs, K</au><au>Smyth, H S</au><au>Killinger, D W</au><au>Vale, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mammosomatotroph adenoma of the pituitary associated with gigantism and hyperprolactinemia. A morphological study including immunoelectron microscopy</atitle><jtitle>Acta neuropathologica</jtitle><addtitle>Acta Neuropathol</addtitle><date>1986-01-01</date><risdate>1986</risdate><volume>71</volume><issue>1-2</issue><spage>76</spage><epage>82</epage><pages>76-82</pages><issn>0001-6322</issn><eissn>1432-0533</eissn><abstract>A 29-year old giantess with growth hormone excess and hyperprolactinemia underwent transsphenoidal surgery to remove her pituitary tumor. Electron microscopy revealed a mammosomatotroph adenoma composed of one cell type. Immunoelectron microscopy, using the immunogold technique, demonstrated predominantly growth hormone or prolactin or a varying mixture of both growth hormone and prolactin in the adenoma cells. The presence of growth hormone and prolactin was found not only in the cytoplasm of the same adenoma cells but also in the same secretory granules. In the nontumorous adenohypophysis, somatotrophs and lactotrophs showed ultrastructural signs of hyperactivity. This finding is in contrast with the presence of suppressed somatotrophs and lactotrophs seen in nontumorous portions of adult pituitaries harboring growth hormone or prolactin-secreting adenomas. Our morphological study reinforces the view that growth hormone-producing pituitary tumors, originating in childhood, are different from those of the adult gland.</abstract><cop>Germany</cop><pmid>3776476</pmid><doi>10.1007/BF00687965</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-6322 |
| ispartof | Acta neuropathologica, 1986-01, Vol.71 (1-2), p.76-82 |
| issn | 0001-6322 1432-0533 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adenoma - complications Adenoma - metabolism Adenoma - ultrastructure Adult Female Gigantism - etiology Growth Hormone - metabolism Humans Hyperprolactinemia - etiology Microscopy, Electron Pituitary Neoplasms - complications Pituitary Neoplasms - metabolism Pituitary Neoplasms - ultrastructure Prolactin - metabolism |
| title | Mammosomatotroph adenoma of the pituitary associated with gigantism and hyperprolactinemia. A morphological study including immunoelectron microscopy |
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