Comparison of solution structures of dihydrofolate reductases and enzyme-ligand complexes using cross-reacting antibodies

Polyclonal antibodies against dihydrofolate reductase (DHFR) from the human lymphoblastoid cell line WIL-2/M4 were used as probes to compare the antigenic structures in solution of native DHFRs obtained from a broad range of species and their complexes with substrate, cofactor, and folate antagonist...

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Veröffentlicht in:	Biochemistry (Easton) 1986-09, Vol.25 (19), p.5453-5459
Hauptverfasser:	Ratnam, Manohar, Delcamp, Tavner J, Freisheim, James H
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Antibodies Antigen-Antibody Complex Biological and medical sciences Cell Line Cross Reactions Enzymes and enzyme inhibitors Epitopes - analysis Fundamental and applied biological sciences. Psychology Humans Kinetics Ligands Oxidoreductases Protein Binding Tetrahydrofolate Dehydrogenase - immunology Tetrahydrofolate Dehydrogenase - metabolism
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