Evidence for cortical disconnection as a mechanism of age-related cognitive decline

Normal aging is accompanied by a decline of cognitive abilities, and executive skills may be affected selectively, but the underlying mechanisms remain obscure and preventive strategies are lacking. It has been suggested that cortical "disconnection" due to the loss of white matter fibers...

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Veröffentlicht in:	Neurology 2001-08, Vol.57 (4), p.632-638
Hauptverfasser:	O'SULLIVAN, M, JONES, D. K, SUMMERS, P. E, MORRIS, R. G, WILLIAMS, S. C. R, MARKUS, H. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aging - pathology Aging - psychology Biological and medical sciences Cerebral Cortex - pathology Corpus Callosum - pathology Female Humans Magnetic Resonance Imaging - methods Male Medical sciences Memory Disorders - pathology Memory Disorders - psychology Middle Aged Nerve Fibers, Myelinated - pathology Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Trail Making Test
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