Comparison of the effects of atropine and glycopyrrolate on pulmonary mechanics in patients undergoing fiberoptic bronchoscopy
The effects of atropine and glycopyrrolate on forced vital capacity (FVC), forced expired volume in one second (FEV1), the FEV1/FVC ratio, and peak expiratory flow (PFL) were compared in 44 patients undergoing fiberoptic bronchoscopy under general anesthesia. Both anticholinergic agents improved pul...
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Veröffentlicht in: | Anesthesia and analgesia 1986-12, Vol.65 (12), p.1285-1289 |
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creator | THORBURN, J. R JAMES, M. F. M FELDMAN, C MOYES, D. G DU TOIT, P. S |
description | The effects of atropine and glycopyrrolate on forced vital capacity (FVC), forced expired volume in one second (FEV1), the FEV1/FVC ratio, and peak expiratory flow (PFL) were compared in 44 patients undergoing fiberoptic bronchoscopy under general anesthesia. Both anticholinergic agents improved pulmonary function equally before general anesthesia, but in both groups there was a small and again equal deterioration in pulmonary function after the procedure. The protective effects of the two drugs were not significantly different. Because of the lower incidence of undesirable side effects, glycopyrrolate is recommended as the anticholinergic agent of choice for bronchoscopy. |
doi_str_mv | 10.1213/00000539-198612000-00006 |
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Because of the lower incidence of undesirable side effects, glycopyrrolate is recommended as the anticholinergic agent of choice for bronchoscopy.</description><identifier>ISSN: 0003-2999</identifier><identifier>EISSN: 1526-7598</identifier><identifier>DOI: 10.1213/00000539-198612000-00006</identifier><identifier>PMID: 3777458</identifier><identifier>CODEN: AACRAT</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Anesthetics. Neuromuscular blocking agents ; Atropine - pharmacology ; Biological and medical sciences ; Bronchoscopy ; Female ; Fiber Optic Technology ; Glycopyrrolate - pharmacology ; Humans ; Lung - drug effects ; Male ; Medical sciences ; Neuropharmacology ; Pharmacology. 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R</creatorcontrib><creatorcontrib>JAMES, M. F. M</creatorcontrib><creatorcontrib>FELDMAN, C</creatorcontrib><creatorcontrib>MOYES, D. G</creatorcontrib><creatorcontrib>DU TOIT, P. S</creatorcontrib><title>Comparison of the effects of atropine and glycopyrrolate on pulmonary mechanics in patients undergoing fiberoptic bronchoscopy</title><title>Anesthesia and analgesia</title><addtitle>Anesth Analg</addtitle><description>The effects of atropine and glycopyrrolate on forced vital capacity (FVC), forced expired volume in one second (FEV1), the FEV1/FVC ratio, and peak expiratory flow (PFL) were compared in 44 patients undergoing fiberoptic bronchoscopy under general anesthesia. Both anticholinergic agents improved pulmonary function equally before general anesthesia, but in both groups there was a small and again equal deterioration in pulmonary function after the procedure. The protective effects of the two drugs were not significantly different. Because of the lower incidence of undesirable side effects, glycopyrrolate is recommended as the anticholinergic agent of choice for bronchoscopy.</description><subject>Anesthetics. Neuromuscular blocking agents</subject><subject>Atropine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Bronchoscopy</subject><subject>Female</subject><subject>Fiber Optic Technology</subject><subject>Glycopyrrolate - pharmacology</subject><subject>Humans</subject><subject>Lung - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pulmonary Ventilation - drug effects</subject><subject>Pyrrolidines - pharmacology</subject><subject>Random Allocation</subject><issn>0003-2999</issn><issn>1526-7598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UE1v1DAUtFBRWQo_AckH1FsgL_6Kj2jVAtJKXOAcOc7zrlFiBzs57KW_vQ7d7rs8zbyZsTyEUKi_QAPsa72NYLoC3UpoCqg2Rr4hOxCNrJTQ7Q3ZFYpVjdb6HXmf898CoW7lLbllSiku2h152sdpNsnnGGh0dDkhRefQLnmDZklx9gGpCQM9jmcb53NKcTQL0mKY13GKwaQzndCeTPA2U19os3gMJWENA6Zj9OFIne-xZC3e0j7FYE8xb2EfyFtnxowfL_uO_Hl8-L3_UR1-ff-5_3aoLGv1Ug1olFacy1b0VjIpuJZD3VuhjRicQmvB6EZzDo0zHJgCUA4GoZxzSqiB3ZH7l9w5xX8r5qWbfLY4jiZgXHOnFHAtZF2E7YvQpphzQtfNyU_lix3U3VZ991p9d63-PyWL9dPljbWfcLgaL12X--fL3WRrRpdMsD5fZUrzGqBhzyeqjqc</recordid><startdate>19861201</startdate><enddate>19861201</enddate><creator>THORBURN, J. R</creator><creator>JAMES, M. F. 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Neuromuscular blocking agents</topic><topic>Atropine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Bronchoscopy</topic><topic>Female</topic><topic>Fiber Optic Technology</topic><topic>Glycopyrrolate - pharmacology</topic><topic>Humans</topic><topic>Lung - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pulmonary Ventilation - drug effects</topic><topic>Pyrrolidines - pharmacology</topic><topic>Random Allocation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>THORBURN, J. R</creatorcontrib><creatorcontrib>JAMES, M. F. M</creatorcontrib><creatorcontrib>FELDMAN, C</creatorcontrib><creatorcontrib>MOYES, D. G</creatorcontrib><creatorcontrib>DU TOIT, P. 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S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the effects of atropine and glycopyrrolate on pulmonary mechanics in patients undergoing fiberoptic bronchoscopy</atitle><jtitle>Anesthesia and analgesia</jtitle><addtitle>Anesth Analg</addtitle><date>1986-12-01</date><risdate>1986</risdate><volume>65</volume><issue>12</issue><spage>1285</spage><epage>1289</epage><pages>1285-1289</pages><issn>0003-2999</issn><eissn>1526-7598</eissn><coden>AACRAT</coden><abstract>The effects of atropine and glycopyrrolate on forced vital capacity (FVC), forced expired volume in one second (FEV1), the FEV1/FVC ratio, and peak expiratory flow (PFL) were compared in 44 patients undergoing fiberoptic bronchoscopy under general anesthesia. Both anticholinergic agents improved pulmonary function equally before general anesthesia, but in both groups there was a small and again equal deterioration in pulmonary function after the procedure. The protective effects of the two drugs were not significantly different. Because of the lower incidence of undesirable side effects, glycopyrrolate is recommended as the anticholinergic agent of choice for bronchoscopy.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>3777458</pmid><doi>10.1213/00000539-198612000-00006</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Anesthetics. Neuromuscular blocking agents Atropine - pharmacology Biological and medical sciences Bronchoscopy Female Fiber Optic Technology Glycopyrrolate - pharmacology Humans Lung - drug effects Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Pulmonary Ventilation - drug effects Pyrrolidines - pharmacology Random Allocation |
title | Comparison of the effects of atropine and glycopyrrolate on pulmonary mechanics in patients undergoing fiberoptic bronchoscopy |
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