OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins

Recent biochemical and genetic studies indicate that in addition to the octamer-binding proteins Oct-1 and Oct-2, other B cell components are required for lymphoid-restricted, octamer site-mediated immunoglobulin gene promoter activity. Using a genetic screen in yeast, we have isolated B cell-derive...

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Veröffentlicht in:	Cell 1995-02, Vol.80 (3), p.497-506
Hauptverfasser:	Strubin, Michel, Newell, John W, Matthias, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence amino acid sequence prediction B-Lymphocytes cDNA Cell Line Cloning, Molecular DNA - metabolism DNA-Binding Proteins - metabolism gene expression Gene Expression Regulation - physiology Gene Library Genes, Immunoglobulin - genetics HeLa Cells Host Cell Factor C1 Humans immunoglobulins lymphocytes B man Molecular Sequence Data Oct-binding factor 1 Octamer Transcription Factor-1 Octamer Transcription Factor-2 octamer-binding protein Organ Specificity Promoter Regions, Genetic - genetics RNA RNA, Fungal - analysis RNA, Messenger - analysis Sequence Analysis, DNA Trans-Activators - genetics Trans-Activators - metabolism transcription factors Transcription Factors - metabolism Transcriptional Activation - genetics Yeasts - genetics
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