Cytokine secretion and eicosanoid production in the peripheral blood mononuclear cells of MS patients undergoing dietary supplementation with n-3 polyunsaturated fatty acids
To demonstrate the influence of n-3 PUFA supplementation on cytokine and eicosanoid production in peripheral blood mononuclear cells (PBMCs) of MS patients (MSP), we investigated the impact of a 6-month dietary supplementation with these fatty acids on the levels of interleukin-lbeta (IL-1β), IL-2,...
Gespeichert in:
| Veröffentlicht in: | Journal of neuroimmunology 1995-02, Vol.56 (2), p.143-153 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 153 |
|---|---|
| container_issue | 2 |
| container_start_page | 143 |
| container_title | Journal of neuroimmunology |
| container_volume | 56 |
| creator | Gallai, Virgilio Sarchielli, Paola Trequattrini, Alberto Franceschini, Maristella Floridi, Ardesio Firenze, Caterina Alberti, Andrea Benedetto, Daniela Di Stragliotto, Eduardo |
| description | To demonstrate the influence of
n-3 PUFA supplementation on cytokine and eicosanoid production in peripheral blood mononuclear cells (PBMCs) of MS patients (MSP), we investigated the impact of a 6-month dietary supplementation with these fatty acids on the levels of interleukin-lbeta (IL-1β), IL-2, interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) in the supernatants of stimulated PBMCs and serum soluble IL-2 receptors in a group of 20 relapsing-remitting (R-R) MSP and a group of 15 age-matched control individuals (CI). The production of PGE2 and LTB4 in the stimulated PBMCs was also assessed in patient and control groups supplemented with
n-3 PUFAs. In both groups,
n-3 PUFA supplementation led to a significant decrease in the levels of IL-1β and TNF-α, and this reduction was more pronounced in the 3rd and 6th month of supplementation. An analogous decrease was observed in the levels of IL-2 and IFN-γ produced by stimulated PBMCs, and in the levels of serum soluble IL-2 receptors,
n-3 PUFA supplementation also appeared to significantly affect prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) production in PBMCs, both in MSP and the control group. The reduced production of these proinflammatory eicosanoids, and the decrease of some cytokines with an immunohenancing effect as a consequence of
n-3 PUFA supplementation, could modulate some immune functions which have been demonstrated to be altered in MSP. |
| doi_str_mv | 10.1016/0165-5728(94)00140-J |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77146597</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>016557289400140J</els_id><sourcerecordid>77146597</sourcerecordid><originalsourceid>FETCH-LOGICAL-c357t-1afe74029ae3e52e65eaa3091e44a02f9406c1fe4bb93140a87434eca0ffc5b53</originalsourceid><addsrcrecordid>eNp9kc2O1DAQhC0EWmYX3gAknxB7CNiJHScXJDTib7WIA3C2OnZnx5DYwXZA81C8I54f7ZGD1YeqLqv6I-QZZ6844-3r8mQlVd297MU1Y1yw6uYB2fBO1VUnav6QbO4tj8llSj-KSTaivyAXqmuZ4mxD_m73Ofx0HmlCEzG74Cl4S9GZkMAHZ-kSg13NUXGe5h3SBaNbdhhhosMUgqVz8MGvZkKI1OA0JRpG-vkrXSA79DnR1VuMd8H5O2odZoh7mtZlmXAuMhyz_7i8o75q6BKm_eoT5DVCRktHyHlPwTibnpBHI0wJn57nFfn-_t237cfq9suHT9u3t5VppMoVhxGVYHUP2KCssZUI0LCeoxDA6rEXrDV8RDEMfVPuBp0SjUADbByNHGRzRV6cckv3XyumrGeXDsXAY1iTVoqLVvaqGMXJaGJIKeKol-jmUk9zpg-U9AGBPiDQvdBHSvqmrD0_56_DjPZ-6Yyl6G9OOpaSvx1GnUw5pEHrIpqsbXD__-AfnGam2w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77146597</pqid></control><display><type>article</type><title>Cytokine secretion and eicosanoid production in the peripheral blood mononuclear cells of MS patients undergoing dietary supplementation with n-3 polyunsaturated fatty acids</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Gallai, Virgilio ; Sarchielli, Paola ; Trequattrini, Alberto ; Franceschini, Maristella ; Floridi, Ardesio ; Firenze, Caterina ; Alberti, Andrea ; Benedetto, Daniela Di ; Stragliotto, Eduardo</creator><creatorcontrib>Gallai, Virgilio ; Sarchielli, Paola ; Trequattrini, Alberto ; Franceschini, Maristella ; Floridi, Ardesio ; Firenze, Caterina ; Alberti, Andrea ; Benedetto, Daniela Di ; Stragliotto, Eduardo</creatorcontrib><description>To demonstrate the influence of
n-3 PUFA supplementation on cytokine and eicosanoid production in peripheral blood mononuclear cells (PBMCs) of MS patients (MSP), we investigated the impact of a 6-month dietary supplementation with these fatty acids on the levels of interleukin-lbeta (IL-1β), IL-2, interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) in the supernatants of stimulated PBMCs and serum soluble IL-2 receptors in a group of 20 relapsing-remitting (R-R) MSP and a group of 15 age-matched control individuals (CI). The production of PGE2 and LTB4 in the stimulated PBMCs was also assessed in patient and control groups supplemented with
n-3 PUFAs. In both groups,
n-3 PUFA supplementation led to a significant decrease in the levels of IL-1β and TNF-α, and this reduction was more pronounced in the 3rd and 6th month of supplementation. An analogous decrease was observed in the levels of IL-2 and IFN-γ produced by stimulated PBMCs, and in the levels of serum soluble IL-2 receptors,
n-3 PUFA supplementation also appeared to significantly affect prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) production in PBMCs, both in MSP and the control group. The reduced production of these proinflammatory eicosanoids, and the decrease of some cytokines with an immunohenancing effect as a consequence of
n-3 PUFA supplementation, could modulate some immune functions which have been demonstrated to be altered in MSP.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/0165-5728(94)00140-J</identifier><identifier>PMID: 7860710</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Cytokines ; Cytokines - biosynthesis ; Dinoprostone - biosynthesis ; Fatty Acids, Omega-3 - administration & dosage ; Humans ; Interferon-gamma - biosynthesis ; Interleukin-1 - biosynthesis ; Interleukin-2 - biosynthesis ; Leukocytes, Mononuclear - metabolism ; Leukotriene B4 ; Leukotriene B4 - biosynthesis ; Lipopolysaccharides - pharmacology ; Middle Aged ; Mononuclear cells ; Multiple sclerosis ; Multiple Sclerosis - metabolism ; n-3 PUFA supplementation ; Prostaglandin E2 ; Receptors, Interleukin-2 - analysis ; Soluble interleukin-2 receptors ; Tumor Necrosis Factor-alpha - biosynthesis</subject><ispartof>Journal of neuroimmunology, 1995-02, Vol.56 (2), p.143-153</ispartof><rights>1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-1afe74029ae3e52e65eaa3091e44a02f9406c1fe4bb93140a87434eca0ffc5b53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/016557289400140J$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7860710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gallai, Virgilio</creatorcontrib><creatorcontrib>Sarchielli, Paola</creatorcontrib><creatorcontrib>Trequattrini, Alberto</creatorcontrib><creatorcontrib>Franceschini, Maristella</creatorcontrib><creatorcontrib>Floridi, Ardesio</creatorcontrib><creatorcontrib>Firenze, Caterina</creatorcontrib><creatorcontrib>Alberti, Andrea</creatorcontrib><creatorcontrib>Benedetto, Daniela Di</creatorcontrib><creatorcontrib>Stragliotto, Eduardo</creatorcontrib><title>Cytokine secretion and eicosanoid production in the peripheral blood mononuclear cells of MS patients undergoing dietary supplementation with n-3 polyunsaturated fatty acids</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>To demonstrate the influence of
n-3 PUFA supplementation on cytokine and eicosanoid production in peripheral blood mononuclear cells (PBMCs) of MS patients (MSP), we investigated the impact of a 6-month dietary supplementation with these fatty acids on the levels of interleukin-lbeta (IL-1β), IL-2, interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) in the supernatants of stimulated PBMCs and serum soluble IL-2 receptors in a group of 20 relapsing-remitting (R-R) MSP and a group of 15 age-matched control individuals (CI). The production of PGE2 and LTB4 in the stimulated PBMCs was also assessed in patient and control groups supplemented with
n-3 PUFAs. In both groups,
n-3 PUFA supplementation led to a significant decrease in the levels of IL-1β and TNF-α, and this reduction was more pronounced in the 3rd and 6th month of supplementation. An analogous decrease was observed in the levels of IL-2 and IFN-γ produced by stimulated PBMCs, and in the levels of serum soluble IL-2 receptors,
n-3 PUFA supplementation also appeared to significantly affect prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) production in PBMCs, both in MSP and the control group. The reduced production of these proinflammatory eicosanoids, and the decrease of some cytokines with an immunohenancing effect as a consequence of
n-3 PUFA supplementation, could modulate some immune functions which have been demonstrated to be altered in MSP.</description><subject>Adult</subject><subject>Cytokines</subject><subject>Cytokines - biosynthesis</subject><subject>Dinoprostone - biosynthesis</subject><subject>Fatty Acids, Omega-3 - administration & dosage</subject><subject>Humans</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Interleukin-1 - biosynthesis</subject><subject>Interleukin-2 - biosynthesis</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Leukotriene B4</subject><subject>Leukotriene B4 - biosynthesis</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Middle Aged</subject><subject>Mononuclear cells</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - metabolism</subject><subject>n-3 PUFA supplementation</subject><subject>Prostaglandin E2</subject><subject>Receptors, Interleukin-2 - analysis</subject><subject>Soluble interleukin-2 receptors</subject><subject>Tumor Necrosis Factor-alpha - biosynthesis</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2O1DAQhC0EWmYX3gAknxB7CNiJHScXJDTib7WIA3C2OnZnx5DYwXZA81C8I54f7ZGD1YeqLqv6I-QZZ6844-3r8mQlVd297MU1Y1yw6uYB2fBO1VUnav6QbO4tj8llSj-KSTaivyAXqmuZ4mxD_m73Ofx0HmlCEzG74Cl4S9GZkMAHZ-kSg13NUXGe5h3SBaNbdhhhosMUgqVz8MGvZkKI1OA0JRpG-vkrXSA79DnR1VuMd8H5O2odZoh7mtZlmXAuMhyz_7i8o75q6BKm_eoT5DVCRktHyHlPwTibnpBHI0wJn57nFfn-_t237cfq9suHT9u3t5VppMoVhxGVYHUP2KCssZUI0LCeoxDA6rEXrDV8RDEMfVPuBp0SjUADbByNHGRzRV6cckv3XyumrGeXDsXAY1iTVoqLVvaqGMXJaGJIKeKol-jmUk9zpg-U9AGBPiDQvdBHSvqmrD0_56_DjPZ-6Yyl6G9OOpaSvx1GnUw5pEHrIpqsbXD__-AfnGam2w</recordid><startdate>19950201</startdate><enddate>19950201</enddate><creator>Gallai, Virgilio</creator><creator>Sarchielli, Paola</creator><creator>Trequattrini, Alberto</creator><creator>Franceschini, Maristella</creator><creator>Floridi, Ardesio</creator><creator>Firenze, Caterina</creator><creator>Alberti, Andrea</creator><creator>Benedetto, Daniela Di</creator><creator>Stragliotto, Eduardo</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950201</creationdate><title>Cytokine secretion and eicosanoid production in the peripheral blood mononuclear cells of MS patients undergoing dietary supplementation with n-3 polyunsaturated fatty acids</title><author>Gallai, Virgilio ; Sarchielli, Paola ; Trequattrini, Alberto ; Franceschini, Maristella ; Floridi, Ardesio ; Firenze, Caterina ; Alberti, Andrea ; Benedetto, Daniela Di ; Stragliotto, Eduardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-1afe74029ae3e52e65eaa3091e44a02f9406c1fe4bb93140a87434eca0ffc5b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Cytokines</topic><topic>Cytokines - biosynthesis</topic><topic>Dinoprostone - biosynthesis</topic><topic>Fatty Acids, Omega-3 - administration & dosage</topic><topic>Humans</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Interleukin-1 - biosynthesis</topic><topic>Interleukin-2 - biosynthesis</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Leukotriene B4</topic><topic>Leukotriene B4 - biosynthesis</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Middle Aged</topic><topic>Mononuclear cells</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - metabolism</topic><topic>n-3 PUFA supplementation</topic><topic>Prostaglandin E2</topic><topic>Receptors, Interleukin-2 - analysis</topic><topic>Soluble interleukin-2 receptors</topic><topic>Tumor Necrosis Factor-alpha - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gallai, Virgilio</creatorcontrib><creatorcontrib>Sarchielli, Paola</creatorcontrib><creatorcontrib>Trequattrini, Alberto</creatorcontrib><creatorcontrib>Franceschini, Maristella</creatorcontrib><creatorcontrib>Floridi, Ardesio</creatorcontrib><creatorcontrib>Firenze, Caterina</creatorcontrib><creatorcontrib>Alberti, Andrea</creatorcontrib><creatorcontrib>Benedetto, Daniela Di</creatorcontrib><creatorcontrib>Stragliotto, Eduardo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gallai, Virgilio</au><au>Sarchielli, Paola</au><au>Trequattrini, Alberto</au><au>Franceschini, Maristella</au><au>Floridi, Ardesio</au><au>Firenze, Caterina</au><au>Alberti, Andrea</au><au>Benedetto, Daniela Di</au><au>Stragliotto, Eduardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytokine secretion and eicosanoid production in the peripheral blood mononuclear cells of MS patients undergoing dietary supplementation with n-3 polyunsaturated fatty acids</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>1995-02-01</date><risdate>1995</risdate><volume>56</volume><issue>2</issue><spage>143</spage><epage>153</epage><pages>143-153</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>To demonstrate the influence of
n-3 PUFA supplementation on cytokine and eicosanoid production in peripheral blood mononuclear cells (PBMCs) of MS patients (MSP), we investigated the impact of a 6-month dietary supplementation with these fatty acids on the levels of interleukin-lbeta (IL-1β), IL-2, interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) in the supernatants of stimulated PBMCs and serum soluble IL-2 receptors in a group of 20 relapsing-remitting (R-R) MSP and a group of 15 age-matched control individuals (CI). The production of PGE2 and LTB4 in the stimulated PBMCs was also assessed in patient and control groups supplemented with
n-3 PUFAs. In both groups,
n-3 PUFA supplementation led to a significant decrease in the levels of IL-1β and TNF-α, and this reduction was more pronounced in the 3rd and 6th month of supplementation. An analogous decrease was observed in the levels of IL-2 and IFN-γ produced by stimulated PBMCs, and in the levels of serum soluble IL-2 receptors,
n-3 PUFA supplementation also appeared to significantly affect prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) production in PBMCs, both in MSP and the control group. The reduced production of these proinflammatory eicosanoids, and the decrease of some cytokines with an immunohenancing effect as a consequence of
n-3 PUFA supplementation, could modulate some immune functions which have been demonstrated to be altered in MSP.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>7860710</pmid><doi>10.1016/0165-5728(94)00140-J</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-5728 |
| ispartof | Journal of neuroimmunology, 1995-02, Vol.56 (2), p.143-153 |
| issn | 0165-5728 1872-8421 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77146597 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Cytokines Cytokines - biosynthesis Dinoprostone - biosynthesis Fatty Acids, Omega-3 - administration & dosage Humans Interferon-gamma - biosynthesis Interleukin-1 - biosynthesis Interleukin-2 - biosynthesis Leukocytes, Mononuclear - metabolism Leukotriene B4 Leukotriene B4 - biosynthesis Lipopolysaccharides - pharmacology Middle Aged Mononuclear cells Multiple sclerosis Multiple Sclerosis - metabolism n-3 PUFA supplementation Prostaglandin E2 Receptors, Interleukin-2 - analysis Soluble interleukin-2 receptors Tumor Necrosis Factor-alpha - biosynthesis |
| title | Cytokine secretion and eicosanoid production in the peripheral blood mononuclear cells of MS patients undergoing dietary supplementation with n-3 polyunsaturated fatty acids |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T13%3A43%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cytokine%20secretion%20and%20eicosanoid%20production%20in%20the%20peripheral%20blood%20mononuclear%20cells%20of%20MS%20patients%20undergoing%20dietary%20supplementation%20with%20n-3%20polyunsaturated%20fatty%20acids&rft.jtitle=Journal%20of%20neuroimmunology&rft.au=Gallai,%20Virgilio&rft.date=1995-02-01&rft.volume=56&rft.issue=2&rft.spage=143&rft.epage=153&rft.pages=143-153&rft.issn=0165-5728&rft.eissn=1872-8421&rft_id=info:doi/10.1016/0165-5728(94)00140-J&rft_dat=%3Cproquest_cross%3E77146597%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77146597&rft_id=info:pmid/7860710&rft_els_id=016557289400140J&rfr_iscdi=true |