The compatibility and stability of octreotide acetate in the presence of diamorphine hydrochloride in polypropylene syringes
Varying concentrations of octreotide acetate (Sandostatin®) and diamorphine hydrochloride were prepared and stored in polypropylene syringes at 37°C in the dark. The solutions were analysed for octreotide acetate content using a validated HPLC method at regular intervals over a 48-h period. The resu...
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| Veröffentlicht in: | Palliative medicine 2000-05, Vol.14 (3), p.205-208 |
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| container_title | Palliative medicine |
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| creator | Fielding, H Kyaterekera, N Skellern, G G Tettey, J N McDade, J R Msuya, Z Watson, D G Urie, J |
| description | Varying concentrations of octreotide acetate (Sandostatin®) and diamorphine hydrochloride were prepared and stored in polypropylene syringes at 37°C in the dark. The solutions were analysed for octreotide acetate content using a validated HPLC method at regular intervals over a 48-h period. The results indicate that octreotide acetate remains stable in the presence of diamorphine hydrochloride at 37°C for 24 h. In addition, the solutions prepared maintained their clarity, with no signs of precipitation upon visual examination under normal light conditions. |
| doi_str_mv | 10.1191/026921600666997498 |
| format | Article |
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Organ gift and preservation</subject><subject>Drug Combinations</subject><subject>Drug Stability</subject><subject>Drug Storage</subject><subject>Gastrointestinal Agents - chemistry</subject><subject>Heroin - chemistry</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Octreotide - chemistry</subject><subject>Palliative Care</subject><subject>Syringes</subject><issn>0269-2163</issn><issn>1477-030X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>BENPR</sourceid><recordid>eNp90ctq3DAUBmBRGprJJC_QRTClpCsnulmXZRiSNhDIZgrdGVk-zijYlitpFoY-fGVmICWFrITQ9x8d6SD0meBrQjS5wVRoSgTGQgitJdfqA1oRLmWJGf71Ea0WUGbBTtFZjC8YE4YF_4ROCVaVUlSt0J_tDgrrh8kk17jepbkwY1vEZI473xXepgA-uRYKYyGZBIUbi5SDU4AIo4VFtc4MPkw7N0Kxm9vg7a73YQllPPl-noKf5h7ycZyDG58hnqOTzvQRLo7rGv28v9tufpSPT98fNrePpeWapVJXncBcayGB6w40cNZAxVplbWMYU0ppLiTnlLWGCF4BdJWkXAJjHWksY2v07VA3t_B7DzHVg4sW-t6M4PexlpJwwXQlsrx6Xy4fL-QCv7yBL34fxvyKmhKpKKaMZkQPyAYfY4CunoIbTJhrguulUv3_CHPo8lh53wzQ_hM5zCyDr0dgojV9F8xoXXx1rMqleWY3BxbNM7x2987NfwG5xbIA</recordid><startdate>20000501</startdate><enddate>20000501</enddate><creator>Fielding, H</creator><creator>Kyaterekera, N</creator><creator>Skellern, G G</creator><creator>Tettey, J N</creator><creator>McDade, J R</creator><creator>Msuya, Z</creator><creator>Watson, D G</creator><creator>Urie, J</creator><general>Sage Publications</general><general>Turpin</general><general>Sage Publications Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QJ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>POGQB</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PRQQA</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20000501</creationdate><title>The compatibility and stability of octreotide acetate in the presence of diamorphine hydrochloride in polypropylene syringes</title><author>Fielding, H ; Kyaterekera, N ; Skellern, G G ; Tettey, J N ; McDade, J R ; Msuya, Z ; Watson, D G ; Urie, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-95f6049967e49fe9e43be53d8ccba3388894674423da1645eef57247e33f1bc33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Analgesics, Opioid - chemistry</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Clinical death. Palliative care. Organ gift and preservation</topic><topic>Drug Combinations</topic><topic>Drug Stability</topic><topic>Drug Storage</topic><topic>Gastrointestinal Agents - chemistry</topic><topic>Heroin - chemistry</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Octreotide - chemistry</topic><topic>Palliative Care</topic><topic>Syringes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fielding, H</creatorcontrib><creatorcontrib>Kyaterekera, N</creatorcontrib><creatorcontrib>Skellern, G G</creatorcontrib><creatorcontrib>Tettey, J N</creatorcontrib><creatorcontrib>McDade, J R</creatorcontrib><creatorcontrib>Msuya, Z</creatorcontrib><creatorcontrib>Watson, D G</creatorcontrib><creatorcontrib>Urie, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Sociology Collection</collection><collection>British Nursing Index</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Sociology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest Sociology & Social Sciences Collection</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Social Sciences</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Palliative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fielding, H</au><au>Kyaterekera, N</au><au>Skellern, G G</au><au>Tettey, J N</au><au>McDade, J R</au><au>Msuya, Z</au><au>Watson, D G</au><au>Urie, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The compatibility and stability of octreotide acetate in the presence of diamorphine hydrochloride in polypropylene syringes</atitle><jtitle>Palliative medicine</jtitle><addtitle>Palliat Med</addtitle><date>2000-05-01</date><risdate>2000</risdate><volume>14</volume><issue>3</issue><spage>205</spage><epage>208</epage><pages>205-208</pages><issn>0269-2163</issn><eissn>1477-030X</eissn><abstract>Varying concentrations of octreotide acetate (Sandostatin®) and diamorphine hydrochloride were prepared and stored in polypropylene syringes at 37°C in the dark. The solutions were analysed for octreotide acetate content using a validated HPLC method at regular intervals over a 48-h period. The results indicate that octreotide acetate remains stable in the presence of diamorphine hydrochloride at 37°C for 24 h. In addition, the solutions prepared maintained their clarity, with no signs of precipitation upon visual examination under normal light conditions.</abstract><cop>Thousand Oaks, CA</cop><pub>Sage Publications</pub><pmid>10858828</pmid><doi>10.1191/026921600666997498</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0269-2163 |
| ispartof | Palliative medicine, 2000-05, Vol.14 (3), p.205-208 |
| issn | 0269-2163 1477-030X |
| language | eng |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; SAGE Complete |
| subjects | Analgesics, Opioid - chemistry Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Clinical death. Palliative care. Organ gift and preservation Drug Combinations Drug Stability Drug Storage Gastrointestinal Agents - chemistry Heroin - chemistry Humans Medical sciences Octreotide - chemistry Palliative Care Syringes |
| title | The compatibility and stability of octreotide acetate in the presence of diamorphine hydrochloride in polypropylene syringes |
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