The imprinted H19 gene as a tumor marker in bladder carcinoma
Objectives. Genomic imprinting is a newly discovered mechanism in genetics that is involved in tumorigenesis. H19 is an imprinted gene in the human, expressed from the maternal allele. It is extensively transcribed in fetal life but is not translated and functions as an RNA molecule. It has been sug...
Gespeichert in:
| Veröffentlicht in: | Urology (Ridgewood, N.J.) N.J.), 1995-02, Vol.45 (2), p.335-338 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 338 |
|---|---|
| container_issue | 2 |
| container_start_page | 335 |
| container_title | Urology (Ridgewood, N.J.) |
| container_volume | 45 |
| creator | Ariel, Ilana Lustig, Orit Schneider, Tamar Pizov, Galina Sappir, Mally De-Groot, Nathan Hochberg, Abraham |
| description | Objectives. Genomic imprinting is a newly discovered mechanism in genetics that is involved in tumorigenesis. H19 is an imprinted gene in the human, expressed from the maternal allele. It is extensively transcribed in fetal life but is not translated and functions as an RNA molecule. It has been suggested as a candidate tumor suppressor gene. We studied the expression of H19 in human cancer arising from tissues expressing H19 fetal life, one of which is bladder mucosa.
Methods. In situ hybridization for H19 mRNA on paraffin sections of bladder carcinoma in different histologic grades.
Results. Low-grade (grade 1 of 3), noninvasive (Ta) papillary transitional cell bladder carcinoma did not express H19, but prominent expression was disclosed in higher grades, invasive transitional cell carcinomas (T1-T3/4). Expression was also evident in in situ bladder carcinoma (Tis), which tends to progress rapidly to invasive cancer.
Conclusions. We suggest that H19 can be used as a tumor marker in human bladder carcinoma, where its expression indicates a more malignant potential. |
| doi_str_mv | 10.1016/0090-4295(95)80030-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77146088</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0090429595800301</els_id><sourcerecordid>77146088</sourcerecordid><originalsourceid>FETCH-LOGICAL-c386t-369812f16b207f409bc83a67217bdc7273c6f45394f2f70777efcf31a439a0c33</originalsourceid><addsrcrecordid>eNp9kEtrGzEQgEVJcFwn_6ABHUJoD9uOVrt6HBIIpo0Lhl6cs9BqR4nSfbjSutB_Hzk2PhYGZmC-GWY-Qj4x-MqAiW8AGoqq1PVnXX9RABwK9oHMWV3KQmtdn5H5CbkgH1N6BQAhhJyRmVR1rZWck7vNC9LQb2MYJmzpimn6jANSm6il064fI-1t_I2RhoE2nW3bXDobXRjG3l6Sc2-7hFfHvCBPP75vlqti_evx5_JhXTiuxFRwoRUrPRNNCdJXoBunuBWyZLJpnSwld8JXNdeVL70EKSV65zmzFdcWHOcLcnvYu43jnx2myfQhOew6O-C4S0ZKVglQKoPVAXRxTCmiN_mz_MA_w8DsrZm9ErNXYnK8WzMsj10f9--aHtvT0FFT7t8c-zY52_loBxfSCeMVUwp0xu4PGGYXfwNGk1zAwWEbIrrJtGP4_x1vZoaFtg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77146088</pqid></control><display><type>article</type><title>The imprinted H19 gene as a tumor marker in bladder carcinoma</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Ariel, Ilana ; Lustig, Orit ; Schneider, Tamar ; Pizov, Galina ; Sappir, Mally ; De-Groot, Nathan ; Hochberg, Abraham</creator><creatorcontrib>Ariel, Ilana ; Lustig, Orit ; Schneider, Tamar ; Pizov, Galina ; Sappir, Mally ; De-Groot, Nathan ; Hochberg, Abraham</creatorcontrib><description>Objectives. Genomic imprinting is a newly discovered mechanism in genetics that is involved in tumorigenesis. H19 is an imprinted gene in the human, expressed from the maternal allele. It is extensively transcribed in fetal life but is not translated and functions as an RNA molecule. It has been suggested as a candidate tumor suppressor gene. We studied the expression of H19 in human cancer arising from tissues expressing H19 fetal life, one of which is bladder mucosa.
Methods. In situ hybridization for H19 mRNA on paraffin sections of bladder carcinoma in different histologic grades.
Results. Low-grade (grade 1 of 3), noninvasive (Ta) papillary transitional cell bladder carcinoma did not express H19, but prominent expression was disclosed in higher grades, invasive transitional cell carcinomas (T1-T3/4). Expression was also evident in in situ bladder carcinoma (Tis), which tends to progress rapidly to invasive cancer.
Conclusions. We suggest that H19 can be used as a tumor marker in human bladder carcinoma, where its expression indicates a more malignant potential.</description><identifier>ISSN: 0090-4295</identifier><identifier>EISSN: 1527-9995</identifier><identifier>DOI: 10.1016/0090-4295(95)80030-1</identifier><identifier>PMID: 7855987</identifier><identifier>CODEN: URGYAZ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Biomarkers, Tumor - genetics ; Carcinoma, Transitional Cell - genetics ; Gene Expression Regulation, Neoplastic - genetics ; Genes - genetics ; Genomic Imprinting ; Humans ; Medical sciences ; Nephrology. Urinary tract diseases ; RNA, Messenger - biosynthesis ; Tumors of the urinary system ; Urinary Bladder Neoplasms - genetics ; Urinary tract. Prostate gland</subject><ispartof>Urology (Ridgewood, N.J.), 1995-02, Vol.45 (2), p.335-338</ispartof><rights>1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-369812f16b207f409bc83a67217bdc7273c6f45394f2f70777efcf31a439a0c33</citedby><cites>FETCH-LOGICAL-c386t-369812f16b207f409bc83a67217bdc7273c6f45394f2f70777efcf31a439a0c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0090-4295(95)80030-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3418809$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7855987$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ariel, Ilana</creatorcontrib><creatorcontrib>Lustig, Orit</creatorcontrib><creatorcontrib>Schneider, Tamar</creatorcontrib><creatorcontrib>Pizov, Galina</creatorcontrib><creatorcontrib>Sappir, Mally</creatorcontrib><creatorcontrib>De-Groot, Nathan</creatorcontrib><creatorcontrib>Hochberg, Abraham</creatorcontrib><title>The imprinted H19 gene as a tumor marker in bladder carcinoma</title><title>Urology (Ridgewood, N.J.)</title><addtitle>Urology</addtitle><description>Objectives. Genomic imprinting is a newly discovered mechanism in genetics that is involved in tumorigenesis. H19 is an imprinted gene in the human, expressed from the maternal allele. It is extensively transcribed in fetal life but is not translated and functions as an RNA molecule. It has been suggested as a candidate tumor suppressor gene. We studied the expression of H19 in human cancer arising from tissues expressing H19 fetal life, one of which is bladder mucosa.
Methods. In situ hybridization for H19 mRNA on paraffin sections of bladder carcinoma in different histologic grades.
Results. Low-grade (grade 1 of 3), noninvasive (Ta) papillary transitional cell bladder carcinoma did not express H19, but prominent expression was disclosed in higher grades, invasive transitional cell carcinomas (T1-T3/4). Expression was also evident in in situ bladder carcinoma (Tis), which tends to progress rapidly to invasive cancer.
Conclusions. We suggest that H19 can be used as a tumor marker in human bladder carcinoma, where its expression indicates a more malignant potential.</description><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Carcinoma, Transitional Cell - genetics</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Genes - genetics</subject><subject>Genomic Imprinting</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Tumors of the urinary system</subject><subject>Urinary Bladder Neoplasms - genetics</subject><subject>Urinary tract. Prostate gland</subject><issn>0090-4295</issn><issn>1527-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtrGzEQgEVJcFwn_6ABHUJoD9uOVrt6HBIIpo0Lhl6cs9BqR4nSfbjSutB_Hzk2PhYGZmC-GWY-Qj4x-MqAiW8AGoqq1PVnXX9RABwK9oHMWV3KQmtdn5H5CbkgH1N6BQAhhJyRmVR1rZWck7vNC9LQb2MYJmzpimn6jANSm6il064fI-1t_I2RhoE2nW3bXDobXRjG3l6Sc2-7hFfHvCBPP75vlqti_evx5_JhXTiuxFRwoRUrPRNNCdJXoBunuBWyZLJpnSwld8JXNdeVL70EKSV65zmzFdcWHOcLcnvYu43jnx2myfQhOew6O-C4S0ZKVglQKoPVAXRxTCmiN_mz_MA_w8DsrZm9ErNXYnK8WzMsj10f9--aHtvT0FFT7t8c-zY52_loBxfSCeMVUwp0xu4PGGYXfwNGk1zAwWEbIrrJtGP4_x1vZoaFtg</recordid><startdate>19950201</startdate><enddate>19950201</enddate><creator>Ariel, Ilana</creator><creator>Lustig, Orit</creator><creator>Schneider, Tamar</creator><creator>Pizov, Galina</creator><creator>Sappir, Mally</creator><creator>De-Groot, Nathan</creator><creator>Hochberg, Abraham</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950201</creationdate><title>The imprinted H19 gene as a tumor marker in bladder carcinoma</title><author>Ariel, Ilana ; Lustig, Orit ; Schneider, Tamar ; Pizov, Galina ; Sappir, Mally ; De-Groot, Nathan ; Hochberg, Abraham</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-369812f16b207f409bc83a67217bdc7273c6f45394f2f70777efcf31a439a0c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Carcinoma, Transitional Cell - genetics</topic><topic>Gene Expression Regulation, Neoplastic - genetics</topic><topic>Genes - genetics</topic><topic>Genomic Imprinting</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Tumors of the urinary system</topic><topic>Urinary Bladder Neoplasms - genetics</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ariel, Ilana</creatorcontrib><creatorcontrib>Lustig, Orit</creatorcontrib><creatorcontrib>Schneider, Tamar</creatorcontrib><creatorcontrib>Pizov, Galina</creatorcontrib><creatorcontrib>Sappir, Mally</creatorcontrib><creatorcontrib>De-Groot, Nathan</creatorcontrib><creatorcontrib>Hochberg, Abraham</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Urology (Ridgewood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ariel, Ilana</au><au>Lustig, Orit</au><au>Schneider, Tamar</au><au>Pizov, Galina</au><au>Sappir, Mally</au><au>De-Groot, Nathan</au><au>Hochberg, Abraham</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The imprinted H19 gene as a tumor marker in bladder carcinoma</atitle><jtitle>Urology (Ridgewood, N.J.)</jtitle><addtitle>Urology</addtitle><date>1995-02-01</date><risdate>1995</risdate><volume>45</volume><issue>2</issue><spage>335</spage><epage>338</epage><pages>335-338</pages><issn>0090-4295</issn><eissn>1527-9995</eissn><coden>URGYAZ</coden><abstract>Objectives. Genomic imprinting is a newly discovered mechanism in genetics that is involved in tumorigenesis. H19 is an imprinted gene in the human, expressed from the maternal allele. It is extensively transcribed in fetal life but is not translated and functions as an RNA molecule. It has been suggested as a candidate tumor suppressor gene. We studied the expression of H19 in human cancer arising from tissues expressing H19 fetal life, one of which is bladder mucosa.
Methods. In situ hybridization for H19 mRNA on paraffin sections of bladder carcinoma in different histologic grades.
Results. Low-grade (grade 1 of 3), noninvasive (Ta) papillary transitional cell bladder carcinoma did not express H19, but prominent expression was disclosed in higher grades, invasive transitional cell carcinomas (T1-T3/4). Expression was also evident in in situ bladder carcinoma (Tis), which tends to progress rapidly to invasive cancer.
Conclusions. We suggest that H19 can be used as a tumor marker in human bladder carcinoma, where its expression indicates a more malignant potential.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>7855987</pmid><doi>10.1016/0090-4295(95)80030-1</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0090-4295 |
| ispartof | Urology (Ridgewood, N.J.), 1995-02, Vol.45 (2), p.335-338 |
| issn | 0090-4295 1527-9995 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77146088 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Biomarkers, Tumor - genetics Carcinoma, Transitional Cell - genetics Gene Expression Regulation, Neoplastic - genetics Genes - genetics Genomic Imprinting Humans Medical sciences Nephrology. Urinary tract diseases RNA, Messenger - biosynthesis Tumors of the urinary system Urinary Bladder Neoplasms - genetics Urinary tract. Prostate gland |
| title | The imprinted H19 gene as a tumor marker in bladder carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T06%3A36%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20imprinted%20H19%20gene%20as%20a%20tumor%20marker%20in%20bladder%20carcinoma&rft.jtitle=Urology%20(Ridgewood,%20N.J.)&rft.au=Ariel,%20Ilana&rft.date=1995-02-01&rft.volume=45&rft.issue=2&rft.spage=335&rft.epage=338&rft.pages=335-338&rft.issn=0090-4295&rft.eissn=1527-9995&rft.coden=URGYAZ&rft_id=info:doi/10.1016/0090-4295(95)80030-1&rft_dat=%3Cproquest_cross%3E77146088%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77146088&rft_id=info:pmid/7855987&rft_els_id=0090429595800301&rfr_iscdi=true |