Backbone Dynamics of Escherichia coli Ribonuclease HI: Correlations with Structure and Function in an Active Enzyme

Ribonuclease H is an endonuclease that hydrolyzes the RNA moiety of RNA–DNA duplex molecules. Escherichia coliribonuclease H is involved in DNA replication, and retroviral ribonuclease H is essential for reverse transcription of the viral genome. To characterize the intramolcular dynamical propertie...

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Veröffentlicht in:	Journal of molecular biology 1995-02, Vol.246 (1), p.144-163
Hauptverfasser:	Mandel, Arthur M., Akke, Mikael, Palmer, III, Arthur G.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Binding Sites Escherichia coli Escherichia coli - enzymology HIV Reverse Transcriptase HIV-1 - enzymology Humans Magnetic Resonance Spectroscopy Models, Molecular molecular dynamics Molecular Structure NMR spectroscopy order parameter Protein Structure, Secondary ribonuclease H Ribonuclease H - chemistry Ribonuclease H - metabolism RNA-Directed DNA Polymerase - chemistry spin relaxation Structure-Activity Relationship
Online-Zugang:	Volltext
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