Evidence for a second pathway in the action mechanism of 2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD) : Significance of Ah-receptor mediated activation of protein kinase under cell-free conditions

2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD) when administered directly to a nuclear-free subcellular homogenate of guinea pig adipose tissue, caused a significant rise in protein kinase activities within 1–10 min. Such a rapid response was not expected, based on the classic transcriptional mechanism...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical pharmacology 1995-01, Vol.49 (2), p.249-261
Hauptverfasser:	Enan, Essam, Matsumura, Fumio
Format:	Artikel
Sprache:	eng
Schlagworte:	adipose tissue Adipose Tissue - metabolism Adipose Tissue - ultrastructure Ah-receptor Amino Acid Sequence Animals Base Sequence Biological and medical sciences cell-free Cell-Free System Chemical and industrial products toxicology. Toxic occupational diseases Dose-Response Relationship, Drug Enzyme Activation - drug effects gel-retardation Genistein Guinea Pigs Isoflavones - pharmacology kinases Male Medical sciences Molecular Sequence Data Phosphoprotein Phosphatases - antagonists & inhibitors Phosphorylation Polychlorinated Dibenzodioxins - antagonists & inhibitors Polychlorinated Dibenzodioxins - metabolism Polychlorinated Dibenzodioxins - pharmacology Protein-Tyrosine Kinases - metabolism Receptors, Aryl Hydrocarbon - antagonists & inhibitors Receptors, Aryl Hydrocarbon - drug effects Receptors, Aryl Hydrocarbon - metabolism Signal Transduction TCDD Toxicology Various organic compounds
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!