Impact Of Metastases on Nodal Immunoreactivity in Head and Neck Cancer
It has been previously demonstrated by the authors that lymph nodes from patients with head and neck cancer are capable of regional immunoreactivity and that this immunoreactivity could be enhanced with certain nonspecific immunostimulants. However, it is unknown how metastases to the neck nodes wou...
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| Veröffentlicht in: | The Laryngoscope 1986-11, Vol.96 (11), p.1189-1192 |
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| container_title | The Laryngoscope |
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| creator | Schuller, David E. Koolemans‐Beynen, Antoinette R. Libby, Debora H. Rinehart, John J. Milo, George E. |
| description | It has been previously demonstrated by the authors that lymph nodes from patients with head and neck cancer are capable of regional immunoreactivity and that this immunoreactivity could be enhanced with certain nonspecific immunostimulants. However, it is unknown how metastases to the neck nodes would affect this immunoreactivity.
The purpose of this study is to compare the immunoreactivity of matched node pairs (metastatic versus nonmetastatic) from head and neck cancer patients. The soft agar assay system was the methodology employed. The effect of nodal lymphocytes on tumor growth in soft agar was studied with and without nonspecific immunostimulation in both normal and metastatic nodes from the same location in the neck in 16 patients.
The results demonstrate that lymph nodes from head and neck cancer patients are capable of an immune reaction to cancer, and that this immunoreactivity appears to be significantly increased in metastatic lymph nodes with and without the use of specific immunostimulants. |
| doi_str_mv | 10.1002/lary.1986.96.11.1189 |
| format | Article |
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The purpose of this study is to compare the immunoreactivity of matched node pairs (metastatic versus nonmetastatic) from head and neck cancer patients. The soft agar assay system was the methodology employed. The effect of nodal lymphocytes on tumor growth in soft agar was studied with and without nonspecific immunostimulation in both normal and metastatic nodes from the same location in the neck in 16 patients.
The results demonstrate that lymph nodes from head and neck cancer patients are capable of an immune reaction to cancer, and that this immunoreactivity appears to be significantly increased in metastatic lymph nodes with and without the use of specific immunostimulants.</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1002/lary.1986.96.11.1189</identifier><identifier>PMID: 3773614</identifier><identifier>CODEN: LARYA8</identifier><language>eng</language><publisher>Honboken, NJ: Wiley-Blackwell</publisher><subject>Antibody Formation ; Biological and medical sciences ; Carcinoma, Squamous Cell - immunology ; Head and Neck Neoplasms - immunology ; Humans ; Lymph Nodes - immunology ; Lymphatic Metastasis ; Medical sciences ; Neck ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology</subject><ispartof>The Laryngoscope, 1986-11, Vol.96 (11), p.1189-1192</ispartof><rights>Copyright © 1986 The Triological Society</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3909-5c12828d907ec4cad1ae6a03c20ecb3a84106c9fe8116360cfda15dca457c33b3</citedby><cites>FETCH-LOGICAL-c3909-5c12828d907ec4cad1ae6a03c20ecb3a84106c9fe8116360cfda15dca457c33b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,23909,23910,25118,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8142811$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3773614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schuller, David E.</creatorcontrib><creatorcontrib>Koolemans‐Beynen, Antoinette R.</creatorcontrib><creatorcontrib>Libby, Debora H.</creatorcontrib><creatorcontrib>Rinehart, John J.</creatorcontrib><creatorcontrib>Milo, George E.</creatorcontrib><title>Impact Of Metastases on Nodal Immunoreactivity in Head and Neck Cancer</title><title>The Laryngoscope</title><addtitle>Laryngoscope</addtitle><description>It has been previously demonstrated by the authors that lymph nodes from patients with head and neck cancer are capable of regional immunoreactivity and that this immunoreactivity could be enhanced with certain nonspecific immunostimulants. However, it is unknown how metastases to the neck nodes would affect this immunoreactivity.
The purpose of this study is to compare the immunoreactivity of matched node pairs (metastatic versus nonmetastatic) from head and neck cancer patients. The soft agar assay system was the methodology employed. The effect of nodal lymphocytes on tumor growth in soft agar was studied with and without nonspecific immunostimulation in both normal and metastatic nodes from the same location in the neck in 16 patients.
The results demonstrate that lymph nodes from head and neck cancer patients are capable of an immune reaction to cancer, and that this immunoreactivity appears to be significantly increased in metastatic lymph nodes with and without the use of specific immunostimulants.</description><subject>Antibody Formation</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - immunology</subject><subject>Head and Neck Neoplasms - immunology</subject><subject>Humans</subject><subject>Lymph Nodes - immunology</subject><subject>Lymphatic Metastasis</subject><subject>Medical sciences</subject><subject>Neck</subject><subject>Otorhinolaryngology (head neck, general aspects and miscellaneous)</subject><subject>Otorhinolaryngology. Stomatology</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtLAzEQgIMotVb_gUIO4m1rZrOb3RxrsbZQWxAFPYVpdhZW91E3rdJ_b_qgZ2EgJPPNIx9j1yD6IER4X2K76YNOVV-rPoCPVJ-wLsQSgkjr-JR1PSaDNA7fz9mFc59CQCJj0WEdmSRSQdRlo0m1RLvi85w_0wqdD3K8qfmsybDkk6pa101LHil-itWGFzUfE2Yc64zPyH7xIdaW2kt2lmPp6Opw9tjb6PF1OA6m86fJcDANrNRCB7GFMA3TTIuEbGQxAySFQtpQkF1ITCMQyuqcUgAllbB5hhBnFqM4sVIuZI_d7fsu2-Z7TW5lqsJZKkusqVk7kyQgk1ApD0Z70LaNcy3lZtkWlTdmQJitPlPuLl6f0coAmK0-X3Zz6L9eVJQdiw6-fP72kEdnscxb__vCHbEUotCv7rGHPfZblLT512gzHbx8bN-0Atjt8gfUj4vp</recordid><startdate>198611</startdate><enddate>198611</enddate><creator>Schuller, David E.</creator><creator>Koolemans‐Beynen, Antoinette R.</creator><creator>Libby, Debora H.</creator><creator>Rinehart, John J.</creator><creator>Milo, George E.</creator><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>198611</creationdate><title>Impact Of Metastases on Nodal Immunoreactivity in Head and Neck Cancer</title><author>Schuller, David E. ; Koolemans‐Beynen, Antoinette R. ; Libby, Debora H. ; Rinehart, John J. ; Milo, George E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3909-5c12828d907ec4cad1ae6a03c20ecb3a84106c9fe8116360cfda15dca457c33b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Antibody Formation</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - immunology</topic><topic>Head and Neck Neoplasms - immunology</topic><topic>Humans</topic><topic>Lymph Nodes - immunology</topic><topic>Lymphatic Metastasis</topic><topic>Medical sciences</topic><topic>Neck</topic><topic>Otorhinolaryngology (head neck, general aspects and miscellaneous)</topic><topic>Otorhinolaryngology. Stomatology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schuller, David E.</creatorcontrib><creatorcontrib>Koolemans‐Beynen, Antoinette R.</creatorcontrib><creatorcontrib>Libby, Debora H.</creatorcontrib><creatorcontrib>Rinehart, John J.</creatorcontrib><creatorcontrib>Milo, George E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schuller, David E.</au><au>Koolemans‐Beynen, Antoinette R.</au><au>Libby, Debora H.</au><au>Rinehart, John J.</au><au>Milo, George E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact Of Metastases on Nodal Immunoreactivity in Head and Neck Cancer</atitle><jtitle>The Laryngoscope</jtitle><addtitle>Laryngoscope</addtitle><date>1986-11</date><risdate>1986</risdate><volume>96</volume><issue>11</issue><spage>1189</spage><epage>1192</epage><pages>1189-1192</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><coden>LARYA8</coden><abstract>It has been previously demonstrated by the authors that lymph nodes from patients with head and neck cancer are capable of regional immunoreactivity and that this immunoreactivity could be enhanced with certain nonspecific immunostimulants. However, it is unknown how metastases to the neck nodes would affect this immunoreactivity.
The purpose of this study is to compare the immunoreactivity of matched node pairs (metastatic versus nonmetastatic) from head and neck cancer patients. The soft agar assay system was the methodology employed. The effect of nodal lymphocytes on tumor growth in soft agar was studied with and without nonspecific immunostimulation in both normal and metastatic nodes from the same location in the neck in 16 patients.
The results demonstrate that lymph nodes from head and neck cancer patients are capable of an immune reaction to cancer, and that this immunoreactivity appears to be significantly increased in metastatic lymph nodes with and without the use of specific immunostimulants.</abstract><cop>Honboken, NJ</cop><pub>Wiley-Blackwell</pub><pmid>3773614</pmid><doi>10.1002/lary.1986.96.11.1189</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | The Laryngoscope, 1986-11, Vol.96 (11), p.1189-1192 |
| issn | 0023-852X 1531-4995 |
| language | eng |
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| source | Journals@Ovid Ovid Autoload; MEDLINE |
| subjects | Antibody Formation Biological and medical sciences Carcinoma, Squamous Cell - immunology Head and Neck Neoplasms - immunology Humans Lymph Nodes - immunology Lymphatic Metastasis Medical sciences Neck Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology |
| title | Impact Of Metastases on Nodal Immunoreactivity in Head and Neck Cancer |
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