Effects of leukotrienes C4, D4, and E4 on cerebral arteries of newborn pigs
We examined effects of topical application of leukotrienes (LT) C4, D4, and E4 on cerebral arteries of newborn pigs in vivo. Diameters of pial arteries were measured using a cranial window method during application of artificial cerebrospinal fluid without drug, and cerebrospinal fluid containing LT...
Gespeichert in:
| Veröffentlicht in: | Pediatric research 1986-10, Vol.20 (10), p.973-976 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 976 |
|---|---|
| container_issue | 10 |
| container_start_page | 973 |
| container_title | Pediatric research |
| container_volume | 20 |
| creator | BUSIJA, D. W LEFFLER, C. W BEASLEY, D. G |
| description | We examined effects of topical application of leukotrienes (LT) C4, D4, and E4 on cerebral arteries of newborn pigs in vivo. Diameters of pial arteries were measured using a cranial window method during application of artificial cerebrospinal fluid without drug, and cerebrospinal fluid containing LT C4, D4, and E4 (1, 10, 100, 1000, and 5000 ng/ml). Control diameters ranged from 51-345 micron. All three LT constricted pial arteries in a dose-dependent manner, with a threshold for detectable response at 10 ng/ml (7 +/- 3% for LTD4). The magnitude of constrictor response at the highest dose was 23 +/- 3% for LTC4, 17 +/- 2% for LTD4, and 17 +/- 3% for LTE4. The specific receptor antagonist FPL 55712 blocked the constrictor response to LT. We conclude that LT are potent constrictors of cerebral arteries in newborn pigs. |
| doi_str_mv | 10.1203/00006450-198610000-00016 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77137254</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77137254</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3046-eb48305b70a517ea78f309586d19404fb7a3c9360b9d69d7c4952b19af49c0363</originalsourceid><addsrcrecordid>eNo9kE1LAzEQhoMotVZ_gpCDeHI12XwfpdYPLHjRc8hmJ7K63a3JFvHfm9q1A0MY5nkT8iCEKbmmJWE3JJfkghTUaEm3U5GbygM0pYLlgXN1iKaEMFowY_QxOknpIxNcaD5BE0bKXHKKnhchgB8S7gNuYfPZD7GBDhKe8yt8l9t1NV5w3HfYQ4Qquha7OECm_jIdfFd97PC6eU-n6Ci4NsHZeM7Q2_3idf5YLF8enua3y8IzwmUBFdeMiEoRJ6gCp3RgxAgta2o44aFSjnnDJKlMLU2tPDeirKhxgRtPmGQzdLm7dx37rw2kwa6a5KFtXQf9JlmlKFOl4BnUO9DHPqUIwa5js3Lxx1Jitx7tv0e792j_PObo-fjGplpBvQ-O4vL-Yty75F0bout8k_aYpobmT7Ff24929Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77137254</pqid></control><display><type>article</type><title>Effects of leukotrienes C4, D4, and E4 on cerebral arteries of newborn pigs</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><source>SpringerLink Journals - AutoHoldings</source><creator>BUSIJA, D. W ; LEFFLER, C. W ; BEASLEY, D. G</creator><creatorcontrib>BUSIJA, D. W ; LEFFLER, C. W ; BEASLEY, D. G</creatorcontrib><description>We examined effects of topical application of leukotrienes (LT) C4, D4, and E4 on cerebral arteries of newborn pigs in vivo. Diameters of pial arteries were measured using a cranial window method during application of artificial cerebrospinal fluid without drug, and cerebrospinal fluid containing LT C4, D4, and E4 (1, 10, 100, 1000, and 5000 ng/ml). Control diameters ranged from 51-345 micron. All three LT constricted pial arteries in a dose-dependent manner, with a threshold for detectable response at 10 ng/ml (7 +/- 3% for LTD4). The magnitude of constrictor response at the highest dose was 23 +/- 3% for LTC4, 17 +/- 2% for LTD4, and 17 +/- 3% for LTE4. The specific receptor antagonist FPL 55712 blocked the constrictor response to LT. We conclude that LT are potent constrictors of cerebral arteries in newborn pigs.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1203/00006450-198610000-00016</identifier><identifier>PMID: 3022226</identifier><identifier>CODEN: PEREBL</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Animals ; Animals, Newborn - physiology ; Biological and medical sciences ; Cerebral Arteries - drug effects ; Cerebral Arteries - physiology ; Chromones - pharmacology ; Clonidine - pharmacology ; Dose-Response Relationship, Drug ; Fundamental and applied biological sciences. Psychology ; Leukotriene E4 ; Prostaglandins. Arachidonic acid metabolites ; SRS-A - analogs & derivatives ; SRS-A - antagonists & inhibitors ; SRS-A - pharmacology ; Swine ; Vasoconstriction - drug effects ; Vertebrates: endocrinology</subject><ispartof>Pediatric research, 1986-10, Vol.20 (10), p.973-976</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3046-eb48305b70a517ea78f309586d19404fb7a3c9360b9d69d7c4952b19af49c0363</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8191309$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3022226$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BUSIJA, D. W</creatorcontrib><creatorcontrib>LEFFLER, C. W</creatorcontrib><creatorcontrib>BEASLEY, D. G</creatorcontrib><title>Effects of leukotrienes C4, D4, and E4 on cerebral arteries of newborn pigs</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><description>We examined effects of topical application of leukotrienes (LT) C4, D4, and E4 on cerebral arteries of newborn pigs in vivo. Diameters of pial arteries were measured using a cranial window method during application of artificial cerebrospinal fluid without drug, and cerebrospinal fluid containing LT C4, D4, and E4 (1, 10, 100, 1000, and 5000 ng/ml). Control diameters ranged from 51-345 micron. All three LT constricted pial arteries in a dose-dependent manner, with a threshold for detectable response at 10 ng/ml (7 +/- 3% for LTD4). The magnitude of constrictor response at the highest dose was 23 +/- 3% for LTC4, 17 +/- 2% for LTD4, and 17 +/- 3% for LTE4. The specific receptor antagonist FPL 55712 blocked the constrictor response to LT. We conclude that LT are potent constrictors of cerebral arteries in newborn pigs.</description><subject>Animals</subject><subject>Animals, Newborn - physiology</subject><subject>Biological and medical sciences</subject><subject>Cerebral Arteries - drug effects</subject><subject>Cerebral Arteries - physiology</subject><subject>Chromones - pharmacology</subject><subject>Clonidine - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Leukotriene E4</subject><subject>Prostaglandins. Arachidonic acid metabolites</subject><subject>SRS-A - analogs & derivatives</subject><subject>SRS-A - antagonists & inhibitors</subject><subject>SRS-A - pharmacology</subject><subject>Swine</subject><subject>Vasoconstriction - drug effects</subject><subject>Vertebrates: endocrinology</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LAzEQhoMotVZ_gpCDeHI12XwfpdYPLHjRc8hmJ7K63a3JFvHfm9q1A0MY5nkT8iCEKbmmJWE3JJfkghTUaEm3U5GbygM0pYLlgXN1iKaEMFowY_QxOknpIxNcaD5BE0bKXHKKnhchgB8S7gNuYfPZD7GBDhKe8yt8l9t1NV5w3HfYQ4Qquha7OECm_jIdfFd97PC6eU-n6Ci4NsHZeM7Q2_3idf5YLF8enua3y8IzwmUBFdeMiEoRJ6gCp3RgxAgta2o44aFSjnnDJKlMLU2tPDeirKhxgRtPmGQzdLm7dx37rw2kwa6a5KFtXQf9JlmlKFOl4BnUO9DHPqUIwa5js3Lxx1Jitx7tv0e792j_PObo-fjGplpBvQ-O4vL-Yty75F0bout8k_aYpobmT7Ff24929Q</recordid><startdate>198610</startdate><enddate>198610</enddate><creator>BUSIJA, D. W</creator><creator>LEFFLER, C. W</creator><creator>BEASLEY, D. G</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198610</creationdate><title>Effects of leukotrienes C4, D4, and E4 on cerebral arteries of newborn pigs</title><author>BUSIJA, D. W ; LEFFLER, C. W ; BEASLEY, D. G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3046-eb48305b70a517ea78f309586d19404fb7a3c9360b9d69d7c4952b19af49c0363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Animals, Newborn - physiology</topic><topic>Biological and medical sciences</topic><topic>Cerebral Arteries - drug effects</topic><topic>Cerebral Arteries - physiology</topic><topic>Chromones - pharmacology</topic><topic>Clonidine - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Leukotriene E4</topic><topic>Prostaglandins. Arachidonic acid metabolites</topic><topic>SRS-A - analogs & derivatives</topic><topic>SRS-A - antagonists & inhibitors</topic><topic>SRS-A - pharmacology</topic><topic>Swine</topic><topic>Vasoconstriction - drug effects</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BUSIJA, D. W</creatorcontrib><creatorcontrib>LEFFLER, C. W</creatorcontrib><creatorcontrib>BEASLEY, D. G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BUSIJA, D. W</au><au>LEFFLER, C. W</au><au>BEASLEY, D. G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of leukotrienes C4, D4, and E4 on cerebral arteries of newborn pigs</atitle><jtitle>Pediatric research</jtitle><addtitle>Pediatr Res</addtitle><date>1986-10</date><risdate>1986</risdate><volume>20</volume><issue>10</issue><spage>973</spage><epage>976</epage><pages>973-976</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><coden>PEREBL</coden><abstract>We examined effects of topical application of leukotrienes (LT) C4, D4, and E4 on cerebral arteries of newborn pigs in vivo. Diameters of pial arteries were measured using a cranial window method during application of artificial cerebrospinal fluid without drug, and cerebrospinal fluid containing LT C4, D4, and E4 (1, 10, 100, 1000, and 5000 ng/ml). Control diameters ranged from 51-345 micron. All three LT constricted pial arteries in a dose-dependent manner, with a threshold for detectable response at 10 ng/ml (7 +/- 3% for LTD4). The magnitude of constrictor response at the highest dose was 23 +/- 3% for LTC4, 17 +/- 2% for LTD4, and 17 +/- 3% for LTE4. The specific receptor antagonist FPL 55712 blocked the constrictor response to LT. We conclude that LT are potent constrictors of cerebral arteries in newborn pigs.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>3022226</pmid><doi>10.1203/00006450-198610000-00016</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-3998 |
| ispartof | Pediatric research, 1986-10, Vol.20 (10), p.973-976 |
| issn | 0031-3998 1530-0447 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77137254 |
| source | MEDLINE; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | Animals Animals, Newborn - physiology Biological and medical sciences Cerebral Arteries - drug effects Cerebral Arteries - physiology Chromones - pharmacology Clonidine - pharmacology Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Leukotriene E4 Prostaglandins. Arachidonic acid metabolites SRS-A - analogs & derivatives SRS-A - antagonists & inhibitors SRS-A - pharmacology Swine Vasoconstriction - drug effects Vertebrates: endocrinology |
| title | Effects of leukotrienes C4, D4, and E4 on cerebral arteries of newborn pigs |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T03%3A02%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20leukotrienes%20C4,%20D4,%20and%20E4%20on%20cerebral%20arteries%20of%20newborn%20pigs&rft.jtitle=Pediatric%20research&rft.au=BUSIJA,%20D.%20W&rft.date=1986-10&rft.volume=20&rft.issue=10&rft.spage=973&rft.epage=976&rft.pages=973-976&rft.issn=0031-3998&rft.eissn=1530-0447&rft.coden=PEREBL&rft_id=info:doi/10.1203/00006450-198610000-00016&rft_dat=%3Cproquest_cross%3E77137254%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77137254&rft_id=info:pmid/3022226&rfr_iscdi=true |