11 beta-Substituted estradiol derivatives, potential high-affinity carbon-11-labeled probes for the estrogen receptor: a structure-affinity relationship study

In view of their possible development as carbon-11-labeled receptor-based radiotracers for imaging estrogen-responsive breast tumors, we have synthesized a series of estradiols (1), estriols (2), 11 beta-ethylestradiols (3), 11 beta-ethylestriols (4), 11 beta-methoxyestradiols (5), and 11 beta-metho...

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Veröffentlicht in:	Journal of medicinal chemistry 1995-02, Vol.38 (3), p.429-434
Hauptverfasser:	Napolitano, E, Fiaschi, R, Carlson, K E, Katzenellenbogen, J A
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Carbon Isotopes Estradiol - analogs & derivatives Estradiol - metabolism Estradiol - pharmacology Magnetic Resonance Spectroscopy Molecular Probes Receptors, Estrogen - chemistry Receptors, Estrogen - drug effects Receptors, Estrogen - metabolism Structure-Activity Relationship
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