Biochemical Effects of Losartan, a Nonpeptide Angiotensin II Receptor Antagonist, on the Renin-Angiotensin-Aldosterone System in Hypertensive Patients

We investigated the effects of angiotensin II (Ang II) type 1 receptor blockade with losartan on the renin-angiotensin-aldosterone system in hypertensive patients (supine diastolic blood pressure, 95 to 110 mm Hg). Qualifying patients (n = 51) were allocated to placebo, 25 or 100 mg losartan, or 20...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 1995-01, Vol.25 (1), p.37-46
Hauptverfasser:	Goldberg, Michael R, Bradstreet, Thomas E, McWilliams, Edward J, Tanaka, Wesley K, Lipert, Stephanie, Bjornsson, Thorir D, Waldman, Scott A, Osborne, Barbara, Pivadori, Lisa, Lewis, George, Blum, Robert, Herman, Theodore, Abraham, Paul A, Halstenson, Charles N, Lo, Man-Wai, Lu, Hannah, Spector, Reynold
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Angiotensin II - antagonists & inhibitors Angiotensin II - blood Angiotensin Receptor Antagonists Antihypertensive agents Biological and medical sciences Biphenyl Compounds - pharmacology Biphenyl Compounds - therapeutic use Cardiovascular system Double-Blind Method Enalapril - pharmacology Female Humans Hypertension - drug therapy Hypertension - physiopathology Imidazoles - pharmacology Imidazoles - therapeutic use Losartan Male Medical sciences Middle Aged Norepinephrine - blood Pharmacology. Drug treatments Renin - blood Renin-Angiotensin System - drug effects Tetrazoles - pharmacology Tetrazoles - therapeutic use
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