REM sleep enhancement by bupropion in depressed men
OBJECTIVE: The authors compared the effects of bupropion, fluoxetine, and cognitive behavior therapy on EEG sleep in depressed subjects. METHOD: All-night sleep EEG studies were performed before treatment and after partial or full remission on 18 men with depression diagnosed according to Research D...
Gespeichert in:
| Veröffentlicht in: | The American journal of psychiatry 1995-02, Vol.152 (2), p.274-276 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 276 |
|---|---|
| container_issue | 2 |
| container_start_page | 274 |
| container_title | The American journal of psychiatry |
| container_volume | 152 |
| creator | NOFZINGER, E. A REYNOLDS, C. F THASE, M. E FRANK, E JENNINGS, J. R FASICZKA, A. L SULLIVAN, L. R KUPFER, D. J |
| description | OBJECTIVE: The authors compared the effects of bupropion, fluoxetine,
and cognitive behavior therapy on EEG sleep in depressed subjects. METHOD:
All-night sleep EEG studies were performed before treatment and after
partial or full remission on 18 men with depression diagnosed according to
Research Diagnostic Criteria and randomly assigned to treatment with either
bupropion (N = 7) or fluoxetine (N = 11). Response to these drugs was
measured by changes in Hamilton Depression Rating Scale scores. Pre- and
posttreatment EEG sleep study results before and after treatment with
cognitive behavior therapy were also available for 18 men matched in age
and severity of Hamilton depression scale score, and one-time EEG sleep
measures were available for 36 men who were not depressed. RESULTS: REM
latency was reduced and REM sleep percent and REM time increased after
treatment in the depressed men given bupropion. These effects contrasted
with the effects of fluoxetine and cognitive behavior therapy. CONCLUSIONS:
This study represents the first report of an antidepressant medication that
shortens REM latency and increases REM sleep. If confirmed, this finding
may require a revision of our current understanding of the relation among
depression, REM sleep, and anti-depressant mechanisms. |
| doi_str_mv | 10.1176/ajp.152.2.274 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77135282</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77135282</sourcerecordid><originalsourceid>FETCH-LOGICAL-a438t-f6a4932a7922164ce82ab21f3c5bebaab509b50085615d855e3c57492dc2a2e53</originalsourceid><addsrcrecordid>eNqFkc1LxDAQxYMo67p69CgUFQ9C12TSNMlRlvUDVgRR8BbSdopd-mWzPex_b5Yti4giwzCE9-PNhEfIKaNTxmR8Y5ftlAmY-pLRHhkzwUUoAdQ-GVNKIdSCvx-SI-eW_km5hBEZSRVRHosx4S_zp8CViG2A9YetU6ywXgXJOkj6tmvaoqmDog4ybDt0DrPAy8fkILelw5NhTsjb3fx19hAunu8fZ7eL0EZcrcI8tpHmYKUGYHGUogKbAMt5KhJMrE0E1b6pEjETmRICvSIjDVkKFlDwCbna-vpDPnt0K1MVLsWytDU2vTNSMi5Awb-gkBJiBcqD5z_AZdN3tf-EAaCRUCzWHrr4C2Kc0ZgqRTdW4ZZKu8a5DnPTdkVlu7Vh1GyCMT4Y44MxvmTk-bPBtU8qzHb0kITXLwfdutSWeeezKNwO41wzqjfY9RazbVt8O-zXnV9szZ_N</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1310608808</pqid></control><display><type>article</type><title>REM sleep enhancement by bupropion in depressed men</title><source>MEDLINE</source><source>Psychiatry Legacy Collection Online Journals 1844-1996</source><source>Periodicals Index Online</source><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><creator>NOFZINGER, E. A ; REYNOLDS, C. F ; THASE, M. E ; FRANK, E ; JENNINGS, J. R ; FASICZKA, A. L ; SULLIVAN, L. R ; KUPFER, D. J</creator><creatorcontrib>NOFZINGER, E. A ; REYNOLDS, C. F ; THASE, M. E ; FRANK, E ; JENNINGS, J. R ; FASICZKA, A. L ; SULLIVAN, L. R ; KUPFER, D. J</creatorcontrib><description>OBJECTIVE: The authors compared the effects of bupropion, fluoxetine,
and cognitive behavior therapy on EEG sleep in depressed subjects. METHOD:
All-night sleep EEG studies were performed before treatment and after
partial or full remission on 18 men with depression diagnosed according to
Research Diagnostic Criteria and randomly assigned to treatment with either
bupropion (N = 7) or fluoxetine (N = 11). Response to these drugs was
measured by changes in Hamilton Depression Rating Scale scores. Pre- and
posttreatment EEG sleep study results before and after treatment with
cognitive behavior therapy were also available for 18 men matched in age
and severity of Hamilton depression scale score, and one-time EEG sleep
measures were available for 36 men who were not depressed. RESULTS: REM
latency was reduced and REM sleep percent and REM time increased after
treatment in the depressed men given bupropion. These effects contrasted
with the effects of fluoxetine and cognitive behavior therapy. CONCLUSIONS:
This study represents the first report of an antidepressant medication that
shortens REM latency and increases REM sleep. If confirmed, this finding
may require a revision of our current understanding of the relation among
depression, REM sleep, and anti-depressant mechanisms.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/ajp.152.2.274</identifier><identifier>PMID: 7840365</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject>Adult ; Age Factors ; Antidepressant drugs ; Biological and medical sciences ; Bupropion - pharmacology ; Bupropion - therapeutic use ; Cognitive Therapy ; Depression ; Depressive Disorder - drug therapy ; Depressive Disorder - psychology ; Depressive Disorder - therapy ; Drugs ; Enhancement ; Fluoxetine - pharmacology ; Fluoxetine - therapeutic use ; Humans ; Male ; Medical sciences ; Men ; Mental depression ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychiatric Status Rating Scales ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Rapid eye movement sleep ; Severity of Illness Index ; Sleep disorders ; Sleep, REM - drug effects ; Sleep, REM - physiology</subject><ispartof>The American journal of psychiatry, 1995-02, Vol.152 (2), p.274-276</ispartof><rights>1995 INIST-CNRS</rights><rights>Copyright American Psychiatric Association Feb 1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a438t-f6a4932a7922164ce82ab21f3c5bebaab509b50085615d855e3c57492dc2a2e53</citedby><cites>FETCH-LOGICAL-a438t-f6a4932a7922164ce82ab21f3c5bebaab509b50085615d855e3c57492dc2a2e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/ajp.152.2.274$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/ajp.152.2.274$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,778,782,2848,21612,27852,27907,27908,30983,77542,77543</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3391095$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7840365$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NOFZINGER, E. A</creatorcontrib><creatorcontrib>REYNOLDS, C. F</creatorcontrib><creatorcontrib>THASE, M. E</creatorcontrib><creatorcontrib>FRANK, E</creatorcontrib><creatorcontrib>JENNINGS, J. R</creatorcontrib><creatorcontrib>FASICZKA, A. L</creatorcontrib><creatorcontrib>SULLIVAN, L. R</creatorcontrib><creatorcontrib>KUPFER, D. J</creatorcontrib><title>REM sleep enhancement by bupropion in depressed men</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>OBJECTIVE: The authors compared the effects of bupropion, fluoxetine,
and cognitive behavior therapy on EEG sleep in depressed subjects. METHOD:
All-night sleep EEG studies were performed before treatment and after
partial or full remission on 18 men with depression diagnosed according to
Research Diagnostic Criteria and randomly assigned to treatment with either
bupropion (N = 7) or fluoxetine (N = 11). Response to these drugs was
measured by changes in Hamilton Depression Rating Scale scores. Pre- and
posttreatment EEG sleep study results before and after treatment with
cognitive behavior therapy were also available for 18 men matched in age
and severity of Hamilton depression scale score, and one-time EEG sleep
measures were available for 36 men who were not depressed. RESULTS: REM
latency was reduced and REM sleep percent and REM time increased after
treatment in the depressed men given bupropion. These effects contrasted
with the effects of fluoxetine and cognitive behavior therapy. CONCLUSIONS:
This study represents the first report of an antidepressant medication that
shortens REM latency and increases REM sleep. If confirmed, this finding
may require a revision of our current understanding of the relation among
depression, REM sleep, and anti-depressant mechanisms.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Antidepressant drugs</subject><subject>Biological and medical sciences</subject><subject>Bupropion - pharmacology</subject><subject>Bupropion - therapeutic use</subject><subject>Cognitive Therapy</subject><subject>Depression</subject><subject>Depressive Disorder - drug therapy</subject><subject>Depressive Disorder - psychology</subject><subject>Depressive Disorder - therapy</subject><subject>Drugs</subject><subject>Enhancement</subject><subject>Fluoxetine - pharmacology</subject><subject>Fluoxetine - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Men</subject><subject>Mental depression</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rapid eye movement sleep</subject><subject>Severity of Illness Index</subject><subject>Sleep disorders</subject><subject>Sleep, REM - drug effects</subject><subject>Sleep, REM - physiology</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><sourceid>7QJ</sourceid><recordid>eNqFkc1LxDAQxYMo67p69CgUFQ9C12TSNMlRlvUDVgRR8BbSdopd-mWzPex_b5Yti4giwzCE9-PNhEfIKaNTxmR8Y5ftlAmY-pLRHhkzwUUoAdQ-GVNKIdSCvx-SI-eW_km5hBEZSRVRHosx4S_zp8CViG2A9YetU6ywXgXJOkj6tmvaoqmDog4ybDt0DrPAy8fkILelw5NhTsjb3fx19hAunu8fZ7eL0EZcrcI8tpHmYKUGYHGUogKbAMt5KhJMrE0E1b6pEjETmRICvSIjDVkKFlDwCbna-vpDPnt0K1MVLsWytDU2vTNSMi5Awb-gkBJiBcqD5z_AZdN3tf-EAaCRUCzWHrr4C2Kc0ZgqRTdW4ZZKu8a5DnPTdkVlu7Vh1GyCMT4Y44MxvmTk-bPBtU8qzHb0kITXLwfdutSWeeezKNwO41wzqjfY9RazbVt8O-zXnV9szZ_N</recordid><startdate>19950201</startdate><enddate>19950201</enddate><creator>NOFZINGER, E. A</creator><creator>REYNOLDS, C. F</creator><creator>THASE, M. E</creator><creator>FRANK, E</creator><creator>JENNINGS, J. R</creator><creator>FASICZKA, A. L</creator><creator>SULLIVAN, L. R</creator><creator>KUPFER, D. J</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>HAWNG</scope><scope>HBMBR</scope><scope>IBDFT</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QJ</scope><scope>7X8</scope></search><sort><creationdate>19950201</creationdate><title>REM sleep enhancement by bupropion in depressed men</title><author>NOFZINGER, E. A ; REYNOLDS, C. F ; THASE, M. E ; FRANK, E ; JENNINGS, J. R ; FASICZKA, A. L ; SULLIVAN, L. R ; KUPFER, D. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a438t-f6a4932a7922164ce82ab21f3c5bebaab509b50085615d855e3c57492dc2a2e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Antidepressant drugs</topic><topic>Biological and medical sciences</topic><topic>Bupropion - pharmacology</topic><topic>Bupropion - therapeutic use</topic><topic>Cognitive Therapy</topic><topic>Depression</topic><topic>Depressive Disorder - drug therapy</topic><topic>Depressive Disorder - psychology</topic><topic>Depressive Disorder - therapy</topic><topic>Drugs</topic><topic>Enhancement</topic><topic>Fluoxetine - pharmacology</topic><topic>Fluoxetine - therapeutic use</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Men</topic><topic>Mental depression</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rapid eye movement sleep</topic><topic>Severity of Illness Index</topic><topic>Sleep disorders</topic><topic>Sleep, REM - drug effects</topic><topic>Sleep, REM - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NOFZINGER, E. A</creatorcontrib><creatorcontrib>REYNOLDS, C. F</creatorcontrib><creatorcontrib>THASE, M. E</creatorcontrib><creatorcontrib>FRANK, E</creatorcontrib><creatorcontrib>JENNINGS, J. R</creatorcontrib><creatorcontrib>FASICZKA, A. L</creatorcontrib><creatorcontrib>SULLIVAN, L. R</creatorcontrib><creatorcontrib>KUPFER, D. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Periodicals Index Online Segment 13</collection><collection>Periodicals Index Online Segment 14</collection><collection>Periodicals Index Online Segment 27</collection><collection>Periodicals Index Online</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - West</collection><collection>Primary Sources Access (Plan D) - International</collection><collection>Primary Sources Access & Build (Plan A) - MEA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Midwest</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Northeast</collection><collection>Primary Sources Access (Plan D) - Southeast</collection><collection>Primary Sources Access (Plan D) - North Central</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Southeast</collection><collection>Primary Sources Access (Plan D) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - UK / I</collection><collection>Primary Sources Access (Plan D) - Canada</collection><collection>Primary Sources Access (Plan D) - EMEALA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - North Central</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - International</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - International</collection><collection>Primary Sources Access (Plan D) - West</collection><collection>Periodicals Index Online Segments 1-50</collection><collection>Primary Sources Access (Plan D) - APAC</collection><collection>Primary Sources Access (Plan D) - Midwest</collection><collection>Primary Sources Access (Plan D) - MEA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Canada</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - UK / I</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - EMEALA</collection><collection>Primary Sources Access & Build (Plan A) - APAC</collection><collection>Primary Sources Access & Build (Plan A) - Canada</collection><collection>Primary Sources Access & Build (Plan A) - West</collection><collection>Primary Sources Access & Build (Plan A) - EMEALA</collection><collection>Primary Sources Access (Plan D) - Northeast</collection><collection>Primary Sources Access & Build (Plan A) - Midwest</collection><collection>Primary Sources Access & Build (Plan A) - North Central</collection><collection>Primary Sources Access & Build (Plan A) - Northeast</collection><collection>Primary Sources Access & Build (Plan A) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - Southeast</collection><collection>Primary Sources Access (Plan D) - UK / I</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - APAC</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - MEA</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NOFZINGER, E. A</au><au>REYNOLDS, C. F</au><au>THASE, M. E</au><au>FRANK, E</au><au>JENNINGS, J. R</au><au>FASICZKA, A. L</au><au>SULLIVAN, L. R</au><au>KUPFER, D. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>REM sleep enhancement by bupropion in depressed men</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>1995-02-01</date><risdate>1995</risdate><volume>152</volume><issue>2</issue><spage>274</spage><epage>276</epage><pages>274-276</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>OBJECTIVE: The authors compared the effects of bupropion, fluoxetine,
and cognitive behavior therapy on EEG sleep in depressed subjects. METHOD:
All-night sleep EEG studies were performed before treatment and after
partial or full remission on 18 men with depression diagnosed according to
Research Diagnostic Criteria and randomly assigned to treatment with either
bupropion (N = 7) or fluoxetine (N = 11). Response to these drugs was
measured by changes in Hamilton Depression Rating Scale scores. Pre- and
posttreatment EEG sleep study results before and after treatment with
cognitive behavior therapy were also available for 18 men matched in age
and severity of Hamilton depression scale score, and one-time EEG sleep
measures were available for 36 men who were not depressed. RESULTS: REM
latency was reduced and REM sleep percent and REM time increased after
treatment in the depressed men given bupropion. These effects contrasted
with the effects of fluoxetine and cognitive behavior therapy. CONCLUSIONS:
This study represents the first report of an antidepressant medication that
shortens REM latency and increases REM sleep. If confirmed, this finding
may require a revision of our current understanding of the relation among
depression, REM sleep, and anti-depressant mechanisms.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>7840365</pmid><doi>10.1176/ajp.152.2.274</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-953X |
| ispartof | The American journal of psychiatry, 1995-02, Vol.152 (2), p.274-276 |
| issn | 0002-953X 1535-7228 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77135282 |
| source | MEDLINE; Psychiatry Legacy Collection Online Journals 1844-1996; Periodicals Index Online; Applied Social Sciences Index & Abstracts (ASSIA) |
| subjects | Adult Age Factors Antidepressant drugs Biological and medical sciences Bupropion - pharmacology Bupropion - therapeutic use Cognitive Therapy Depression Depressive Disorder - drug therapy Depressive Disorder - psychology Depressive Disorder - therapy Drugs Enhancement Fluoxetine - pharmacology Fluoxetine - therapeutic use Humans Male Medical sciences Men Mental depression Neuropharmacology Pharmacology. Drug treatments Psychiatric Status Rating Scales Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rapid eye movement sleep Severity of Illness Index Sleep disorders Sleep, REM - drug effects Sleep, REM - physiology |
| title | REM sleep enhancement by bupropion in depressed men |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T09%3A52%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=REM%20sleep%20enhancement%20by%20bupropion%20in%20depressed%20men&rft.jtitle=The%20American%20journal%20of%20psychiatry&rft.au=NOFZINGER,%20E.%20A&rft.date=1995-02-01&rft.volume=152&rft.issue=2&rft.spage=274&rft.epage=276&rft.pages=274-276&rft.issn=0002-953X&rft.eissn=1535-7228&rft.coden=AJPSAO&rft_id=info:doi/10.1176/ajp.152.2.274&rft_dat=%3Cproquest_cross%3E77135282%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1310608808&rft_id=info:pmid/7840365&rfr_iscdi=true |