Evidence for coupling of the κ opioid receptor to brain GTPase

In membranes from guinea pig cerebellum, a tissue which predominantly contains κ opioid receptors, exogenous and endogenous κ-selective opioid agonists stimulated low-Km GTPase activity by 11–20% with concentrations for half-maximal stimulation of 3–23 μM. Opioid ligands of the μ and δ type had no e...

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Veröffentlicht in:	Life sciences (1973) 1986-11, Vol.39 (19), p.1721-1727
Hauptverfasser:	Clark, Mary J., Levenson, Scott D., Medzihradsky, Fedor
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Animals Brain - metabolism Cell Membrane - metabolism Cerebellum - metabolism Endorphins - pharmacology GTP Phosphohydrolases - metabolism Guinea Pigs Macaca mulatta Naloxone - pharmacology Naltrexone - analogs & derivatives Naltrexone - pharmacology Phosphoric Monoester Hydrolases - metabolism Rats Receptors, Opioid - drug effects Receptors, Opioid - physiology Receptors, Opioid, kappa
Online-Zugang:	Volltext
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