Selective assay for CyPA and CyPB in human blood using highly specific anti-peptide antibodies

Cyclophilins A and B (CyPA and CyPB) are known to be the main binding proteins for cyclosporin A (CsA), a potent immunosuppressive drug. Due to the high homology between the two proteins, antibodies to CyPB were found to cross-react with CyPA. In order to avoid this phenomenon, we raised specific an...

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Veröffentlicht in:	Journal of immunological methods 1995, Vol.178 (1), p.113-120
Hauptverfasser:	Allain, Fabrice, Boutillon, Christophe, Mariller, Christophe, Spik, Geneviève
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Isomerases - blood Amino Acid Isomerases - immunology Amino Acid Sequence Analytical biochemistry: general aspects, technics, instrumentation Analytical, structural and metabolic biochemistry Anti-peptide antibody Antibody Specificity Binding and carrier proteins Biological and medical sciences Carrier Proteins - blood Carrier Proteins - immunology Cyclophilin Cyclophilins Cyclosporin A ELISA Enzyme-Linked Immunosorbent Assay - methods Fundamental and applied biological sciences. Psychology Molecular Sequence Data Neutrophils - chemistry Peptide Fragments - immunology Peptidylprolyl Isomerase Proteins Reference Values Sequence Homology, Amino Acid Tissue Distribution
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