Bryostatin-5 stimulates normal human hematopoiesis and inhibits proliferation of HL60 leukemic cells

In this study we explored the effects of bryostatin-5 on the clonogenic response of normal bone marrow mononuclear (BM) cells and HL60 myeloid leukemia cells. Leukemic HL60 colony formation was strongly inhibited by bryostatin-5 depending on dose and schedule. An inhibitory effect on HL60 colony for...

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Veröffentlicht in:	Leukemia research 1995, Vol.19 (1), p.7-13
Hauptverfasser:	van der Hem, Klaas G., Dräger, Angelika M., Odding, Joan H., Langenhuijsen, Mart M.A.C., Huijgens, Peter C.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute myeloid leukemia Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Bone Marrow - drug effects Bone Marrow Cells Bryostatin-5 Bryostatins Cell Division - drug effects Cell Survival - drug effects colony forming assay General aspects hematopoiesis Hematopoiesis - drug effects HL60 Humans Lactones - pharmacology Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - pathology Macrolides Medical sciences Pharmacology. Drug treatments progenitor cells Stimulation, Chemical Tumor Cells, Cultured
Online-Zugang:	Volltext
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