Bryostatin-5 stimulates normal human hematopoiesis and inhibits proliferation of HL60 leukemic cells
In this study we explored the effects of bryostatin-5 on the clonogenic response of normal bone marrow mononuclear (BM) cells and HL60 myeloid leukemia cells. Leukemic HL60 colony formation was strongly inhibited by bryostatin-5 depending on dose and schedule. An inhibitory effect on HL60 colony for...
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| Veröffentlicht in: | Leukemia research 1995, Vol.19 (1), p.7-13 |
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| creator | van der Hem, Klaas G. Dräger, Angelika M. Odding, Joan H. Langenhuijsen, Mart M.A.C. Huijgens, Peter C. |
| description | In this study we explored the effects of bryostatin-5 on the clonogenic response of normal bone marrow mononuclear (BM) cells and HL60 myeloid leukemia cells. Leukemic HL60 colony formation was strongly inhibited by bryostatin-5 depending on dose and schedule. An inhibitory effect on HL60 colony formation was readily demonstrated after 1 h of exposure, reaching a maximal inhibitory effect at 96 h.
Normal BM cells differed in their clonogenic response: short-term exposure to bryostatin-5 resulted in increased clonogenicity while longstanding exposure to bryostatin-5 permitted the survival of a substantial fraction of committed progenitors. This differential modulation of normal and leukemic myeloid clonogenicity by bryostatin-5 suggests a possible role for bryostatin-5 in the treatment of acute myeloid leukemia. |
| doi_str_mv | 10.1016/0145-2126(94)00118-T |
| format | Article |
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Normal BM cells differed in their clonogenic response: short-term exposure to bryostatin-5 resulted in increased clonogenicity while longstanding exposure to bryostatin-5 permitted the survival of a substantial fraction of committed progenitors. This differential modulation of normal and leukemic myeloid clonogenicity by bryostatin-5 suggests a possible role for bryostatin-5 in the treatment of acute myeloid leukemia.</description><identifier>ISSN: 0145-2126</identifier><identifier>EISSN: 1873-5835</identifier><identifier>DOI: 10.1016/0145-2126(94)00118-T</identifier><identifier>PMID: 7837820</identifier><identifier>CODEN: LEREDD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>acute myeloid leukemia ; Antineoplastic agents ; Antineoplastic Agents - pharmacology ; Biological and medical sciences ; Bone Marrow - drug effects ; Bone Marrow Cells ; Bryostatin-5 ; Bryostatins ; Cell Division - drug effects ; Cell Survival - drug effects ; colony forming assay ; General aspects ; hematopoiesis ; Hematopoiesis - drug effects ; HL60 ; Humans ; Lactones - pharmacology ; Leukemia, Promyelocytic, Acute - drug therapy ; Leukemia, Promyelocytic, Acute - pathology ; Macrolides ; Medical sciences ; Pharmacology. Drug treatments ; progenitor cells ; Stimulation, Chemical ; Tumor Cells, Cultured</subject><ispartof>Leukemia research, 1995, Vol.19 (1), p.7-13</ispartof><rights>1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-1995f825ceb423647fb81b24b0eeb57b16d146fc925f475dc8acd3af8730814b3</citedby><cites>FETCH-LOGICAL-c332t-1995f825ceb423647fb81b24b0eeb57b16d146fc925f475dc8acd3af8730814b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0145-2126(94)00118-T$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,4025,27927,27928,27929,45999</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3426604$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7837820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van der Hem, Klaas G.</creatorcontrib><creatorcontrib>Dräger, Angelika M.</creatorcontrib><creatorcontrib>Odding, Joan H.</creatorcontrib><creatorcontrib>Langenhuijsen, Mart M.A.C.</creatorcontrib><creatorcontrib>Huijgens, Peter C.</creatorcontrib><title>Bryostatin-5 stimulates normal human hematopoiesis and inhibits proliferation of HL60 leukemic cells</title><title>Leukemia research</title><addtitle>Leuk Res</addtitle><description>In this study we explored the effects of bryostatin-5 on the clonogenic response of normal bone marrow mononuclear (BM) cells and HL60 myeloid leukemia cells. Leukemic HL60 colony formation was strongly inhibited by bryostatin-5 depending on dose and schedule. An inhibitory effect on HL60 colony formation was readily demonstrated after 1 h of exposure, reaching a maximal inhibitory effect at 96 h.
Normal BM cells differed in their clonogenic response: short-term exposure to bryostatin-5 resulted in increased clonogenicity while longstanding exposure to bryostatin-5 permitted the survival of a substantial fraction of committed progenitors. This differential modulation of normal and leukemic myeloid clonogenicity by bryostatin-5 suggests a possible role for bryostatin-5 in the treatment of acute myeloid leukemia.</description><subject>acute myeloid leukemia</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow - drug effects</subject><subject>Bone Marrow Cells</subject><subject>Bryostatin-5</subject><subject>Bryostatins</subject><subject>Cell Division - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>colony forming assay</subject><subject>General aspects</subject><subject>hematopoiesis</subject><subject>Hematopoiesis - drug effects</subject><subject>HL60</subject><subject>Humans</subject><subject>Lactones - pharmacology</subject><subject>Leukemia, Promyelocytic, Acute - drug therapy</subject><subject>Leukemia, Promyelocytic, Acute - pathology</subject><subject>Macrolides</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>progenitor cells</subject><subject>Stimulation, Chemical</subject><subject>Tumor Cells, Cultured</subject><issn>0145-2126</issn><issn>1873-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS0EKtvCNwDJB4TgkOK_iXNBgqpQpJV6Wc6W7Yy1hsRebKdSvz0Ju9ojPc1hfu_pzRuE3lByTQltPxEqZMMoaz_04iMhlKpm9wxtqOp4IxWXz9HmjLxEl6X8IoTInvYX6KJTvFOMbNDwNT-mUk0NsZG41DDNo6lQcEx5MiPez5OJeA-TqemQApRQsIkDDnEfbKgFH3Iag4e8OKSIk8d325bgEebfMAWHHYxjeYVeeDMWeH2aV-jnt9vdzV2zvf_-4-bLtnGcs9rQvpdeMenACsZb0XmrqGXCEgArO0vbgYrWu55JLzo5OGXcwI1fDiaKCsuv0Puj7xLqzwyl6imUNYGJkOaiu44yRZh4EqRtJ5Qk_QKKI-hyKiWD14ccJpMfNSV6_YJeK9ZrxboX-t8X9G6RvT35z3aC4Sw61b7s3532pjgz-myiC-WMccHalqwxPx8xWEp7CJB1cQGigyFkcFUPKfw_x18f76PO</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>van der Hem, Klaas G.</creator><creator>Dräger, Angelika M.</creator><creator>Odding, Joan H.</creator><creator>Langenhuijsen, Mart M.A.C.</creator><creator>Huijgens, Peter C.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>Bryostatin-5 stimulates normal human hematopoiesis and inhibits proliferation of HL60 leukemic cells</title><author>van der Hem, Klaas G. ; Dräger, Angelika M. ; Odding, Joan H. ; Langenhuijsen, Mart M.A.C. ; Huijgens, Peter C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-1995f825ceb423647fb81b24b0eeb57b16d146fc925f475dc8acd3af8730814b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>acute myeloid leukemia</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow - drug effects</topic><topic>Bone Marrow Cells</topic><topic>Bryostatin-5</topic><topic>Bryostatins</topic><topic>Cell Division - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>colony forming assay</topic><topic>General aspects</topic><topic>hematopoiesis</topic><topic>Hematopoiesis - drug effects</topic><topic>HL60</topic><topic>Humans</topic><topic>Lactones - pharmacology</topic><topic>Leukemia, Promyelocytic, Acute - drug therapy</topic><topic>Leukemia, Promyelocytic, Acute - pathology</topic><topic>Macrolides</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>progenitor cells</topic><topic>Stimulation, Chemical</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van der Hem, Klaas G.</creatorcontrib><creatorcontrib>Dräger, Angelika M.</creatorcontrib><creatorcontrib>Odding, Joan H.</creatorcontrib><creatorcontrib>Langenhuijsen, Mart M.A.C.</creatorcontrib><creatorcontrib>Huijgens, Peter C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van der Hem, Klaas G.</au><au>Dräger, Angelika M.</au><au>Odding, Joan H.</au><au>Langenhuijsen, Mart M.A.C.</au><au>Huijgens, Peter C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bryostatin-5 stimulates normal human hematopoiesis and inhibits proliferation of HL60 leukemic cells</atitle><jtitle>Leukemia research</jtitle><addtitle>Leuk Res</addtitle><date>1995</date><risdate>1995</risdate><volume>19</volume><issue>1</issue><spage>7</spage><epage>13</epage><pages>7-13</pages><issn>0145-2126</issn><eissn>1873-5835</eissn><coden>LEREDD</coden><abstract>In this study we explored the effects of bryostatin-5 on the clonogenic response of normal bone marrow mononuclear (BM) cells and HL60 myeloid leukemia cells. Leukemic HL60 colony formation was strongly inhibited by bryostatin-5 depending on dose and schedule. An inhibitory effect on HL60 colony formation was readily demonstrated after 1 h of exposure, reaching a maximal inhibitory effect at 96 h.
Normal BM cells differed in their clonogenic response: short-term exposure to bryostatin-5 resulted in increased clonogenicity while longstanding exposure to bryostatin-5 permitted the survival of a substantial fraction of committed progenitors. This differential modulation of normal and leukemic myeloid clonogenicity by bryostatin-5 suggests a possible role for bryostatin-5 in the treatment of acute myeloid leukemia.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>7837820</pmid><doi>10.1016/0145-2126(94)00118-T</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0145-2126 |
| ispartof | Leukemia research, 1995, Vol.19 (1), p.7-13 |
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| language | eng |
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| subjects | acute myeloid leukemia Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Bone Marrow - drug effects Bone Marrow Cells Bryostatin-5 Bryostatins Cell Division - drug effects Cell Survival - drug effects colony forming assay General aspects hematopoiesis Hematopoiesis - drug effects HL60 Humans Lactones - pharmacology Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - pathology Macrolides Medical sciences Pharmacology. Drug treatments progenitor cells Stimulation, Chemical Tumor Cells, Cultured |
| title | Bryostatin-5 stimulates normal human hematopoiesis and inhibits proliferation of HL60 leukemic cells |
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