Treatment of acute idiopathic thrombocytopenic purpura of childhood with intravenous immunoglobulin G: Comparative efficacy of 7S and 5S preparations
A prospective randomized study comparing 7S immunoglobulin G to a 5S IgG preparation for therapy of acute idiopathic thrombocytopenic purpura was conducted. The 5S preparation differed from the 7S preparation in that it lacked part of the Fc portion of the IgG molecule. Both groups were given 400 mg...
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| Veröffentlicht in: | The Journal of pediatrics 1986-11, Vol.109 (5), p.770-775 |
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| container_end_page | 775 |
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| container_issue | 5 |
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| container_title | The Journal of pediatrics |
| container_volume | 109 |
| creator | Burdach, St.E.G. Evers, K.G. Geursen, R.G. |
| description | A prospective randomized study comparing 7S immunoglobulin G to a 5S IgG preparation for therapy of acute idiopathic thrombocytopenic purpura was conducted. The 5S preparation differed from the 7S preparation in that it lacked part of the Fc portion of the IgG molecule. Both groups were given 400 mg IgG/kg body weight over 5 days. All patients had platelet counts ≤30×10
9/L before IgG infusion. Nine of the 10 patients in the 7S treatment group, compared with three of 10 patients in the 5S treatment group, responded to therapy with an increment in platelet counts >100×10
9/L within 4 days of completing the infusion treatment. Furthermore, the rate of increase of the platelets was more rapid in the 7S group. The results emphasize the efficacy of partial Fc for management of acute idiopathic thrombocytopenic purpura. |
| doi_str_mv | 10.1016/S0022-3476(86)80691-6 |
| format | Article |
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9/L before IgG infusion. Nine of the 10 patients in the 7S treatment group, compared with three of 10 patients in the 5S treatment group, responded to therapy with an increment in platelet counts >100×10
9/L within 4 days of completing the infusion treatment. Furthermore, the rate of increase of the platelets was more rapid in the 7S group. The results emphasize the efficacy of partial Fc for management of acute idiopathic thrombocytopenic purpura.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(86)80691-6</identifier><identifier>PMID: 2430084</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Acute Disease ; Adolescent ; Biological and medical sciences ; Child ; Child, Preschool ; Clinical Trials as Topic ; Female ; gamma-Globulins - therapeutic use ; Hematologic and hematopoietic diseases ; Humans ; Male ; Medical sciences ; Platelet Count ; Platelet diseases and coagulopathies ; Prospective Studies ; Purpura, Thrombocytopenic - blood ; Purpura, Thrombocytopenic - therapy ; Random Allocation</subject><ispartof>The Journal of pediatrics, 1986-11, Vol.109 (5), p.770-775</ispartof><rights>1986 The C. V. Mosby Company</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-9db54e803101dc90345fa3fb8a44941fe0035e5c47939c168193c682689538903</citedby><cites>FETCH-LOGICAL-c389t-9db54e803101dc90345fa3fb8a44941fe0035e5c47939c168193c682689538903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0022-3476(86)80691-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8073068$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2430084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burdach, St.E.G.</creatorcontrib><creatorcontrib>Evers, K.G.</creatorcontrib><creatorcontrib>Geursen, R.G.</creatorcontrib><title>Treatment of acute idiopathic thrombocytopenic purpura of childhood with intravenous immunoglobulin G: Comparative efficacy of 7S and 5S preparations</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>A prospective randomized study comparing 7S immunoglobulin G to a 5S IgG preparation for therapy of acute idiopathic thrombocytopenic purpura was conducted. The 5S preparation differed from the 7S preparation in that it lacked part of the Fc portion of the IgG molecule. Both groups were given 400 mg IgG/kg body weight over 5 days. All patients had platelet counts ≤30×10
9/L before IgG infusion. Nine of the 10 patients in the 7S treatment group, compared with three of 10 patients in the 5S treatment group, responded to therapy with an increment in platelet counts >100×10
9/L within 4 days of completing the infusion treatment. Furthermore, the rate of increase of the platelets was more rapid in the 7S group. The results emphasize the efficacy of partial Fc for management of acute idiopathic thrombocytopenic purpura.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical Trials as Topic</subject><subject>Female</subject><subject>gamma-Globulins - therapeutic use</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Platelet Count</subject><subject>Platelet diseases and coagulopathies</subject><subject>Prospective Studies</subject><subject>Purpura, Thrombocytopenic - blood</subject><subject>Purpura, Thrombocytopenic - therapy</subject><subject>Random Allocation</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdGqEzEQhoMox1p9hAO5ENGL1dkmm028ESl6FA540eN1SLOzNrKbrEm20gfxfc3a0lthIJD55p_k_wm5reFtDbV4twPYbCrGW_FaijcShKor8YisalBtJSRjj8nqijwlz1L6CQCKA9yQmw1nAJKvyJ-HiCaP6DMNPTV2zkhd58Jk8sFZmg8xjPtgTzlM6MvFNMdSZoHtwQ3dIYSO_nb5QJ3P0RzRhzlRN46zDz-GsJ8H5-nde7oN42Siye6IFPveWWNPi0i7o8Z3tNnRKeKZCD49J096MyR8cTnX5PvnTw_bL9X9t7uv24_3lWVS5Up1-4ajBFYM6awCxpvesH4vDeeK1z0CsAYby1vFlK2FrBWzQm6EVE0RALYmr866Uwy_ZkxZjy5ZHAbjsfxDt229abhoCticQRtDShF7PUU3mnjSNeglDv0vDr14rWWpJQ4tytztZcG8H7G7Tl38L_2Xl75J1gx9NN66dMUktAxKlmvy4YxhMePoMOpkHXqLnYtos-6C-89D_gJGeKiQ</recordid><startdate>19861101</startdate><enddate>19861101</enddate><creator>Burdach, St.E.G.</creator><creator>Evers, K.G.</creator><creator>Geursen, R.G.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19861101</creationdate><title>Treatment of acute idiopathic thrombocytopenic purpura of childhood with intravenous immunoglobulin G: Comparative efficacy of 7S and 5S preparations</title><author>Burdach, St.E.G. ; Evers, K.G. ; Geursen, R.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-9db54e803101dc90345fa3fb8a44941fe0035e5c47939c168193c682689538903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clinical Trials as Topic</topic><topic>Female</topic><topic>gamma-Globulins - therapeutic use</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Platelet Count</topic><topic>Platelet diseases and coagulopathies</topic><topic>Prospective Studies</topic><topic>Purpura, Thrombocytopenic - blood</topic><topic>Purpura, Thrombocytopenic - therapy</topic><topic>Random Allocation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burdach, St.E.G.</creatorcontrib><creatorcontrib>Evers, K.G.</creatorcontrib><creatorcontrib>Geursen, R.G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burdach, St.E.G.</au><au>Evers, K.G.</au><au>Geursen, R.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of acute idiopathic thrombocytopenic purpura of childhood with intravenous immunoglobulin G: Comparative efficacy of 7S and 5S preparations</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1986-11-01</date><risdate>1986</risdate><volume>109</volume><issue>5</issue><spage>770</spage><epage>775</epage><pages>770-775</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>A prospective randomized study comparing 7S immunoglobulin G to a 5S IgG preparation for therapy of acute idiopathic thrombocytopenic purpura was conducted. The 5S preparation differed from the 7S preparation in that it lacked part of the Fc portion of the IgG molecule. Both groups were given 400 mg IgG/kg body weight over 5 days. All patients had platelet counts ≤30×10
9/L before IgG infusion. Nine of the 10 patients in the 7S treatment group, compared with three of 10 patients in the 5S treatment group, responded to therapy with an increment in platelet counts >100×10
9/L within 4 days of completing the infusion treatment. Furthermore, the rate of increase of the platelets was more rapid in the 7S group. The results emphasize the efficacy of partial Fc for management of acute idiopathic thrombocytopenic purpura.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>2430084</pmid><doi>10.1016/S0022-3476(86)80691-6</doi><tpages>6</tpages></addata></record> |
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| ispartof | The Journal of pediatrics, 1986-11, Vol.109 (5), p.770-775 |
| issn | 0022-3476 1097-6833 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Acute Disease Adolescent Biological and medical sciences Child Child, Preschool Clinical Trials as Topic Female gamma-Globulins - therapeutic use Hematologic and hematopoietic diseases Humans Male Medical sciences Platelet Count Platelet diseases and coagulopathies Prospective Studies Purpura, Thrombocytopenic - blood Purpura, Thrombocytopenic - therapy Random Allocation |
| title | Treatment of acute idiopathic thrombocytopenic purpura of childhood with intravenous immunoglobulin G: Comparative efficacy of 7S and 5S preparations |
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