alpha 1-Antitrypsin therapy in a case of thrombotic thrombocytopenic purpura

In thrombotic thrombocytopenic purpura (TTP), activated leucocytes release elastase which mobilises unusually large von Willebrand factor (vWF) multimers from the endothelium. We investigated the effect of an inhibitor of leucocyte elastase (alpha 1-antitrypsin) on circulating vWF and platelet count...

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Veröffentlicht in:	The Lancet (British edition) 1995-01, Vol.345 (8944), p.224-225
Hauptverfasser:	Galbusera, M, Ruggenenti, P, Noris, M, Burnouf-Radosevich, M, Benigni, A, Mannucci, P M, Remuzzi, G
Format:	Artikel
Sprache:	eng
Schlagworte:	a1-antitrypsin alpha 1-Antitrypsin - therapeutic use Case reports Chronic Disease Elastase Electrophoresis, Agar Gel Endothelium Enzyme-Linked Immunosorbent Assay Health risk assessment Humans Leukocyte Elastase Leukocytes Pancreatic Elastase - antagonists & inhibitors Platelet aggregation Platelet Count - drug effects Purpura Purpura, Thrombotic Thrombocytopenic - drug therapy Remission Thrombocytopenic purpura Thrombotic thrombocytopenic purpura Von Willebrand factor von Willebrand Factor - drug effects von Willebrand Factor - isolation & purification
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