Model study detecting breast cancer cells in peripheral blood mononuclear cells at frequencies as low as 10(-7)

A flow cytometric assay was developed to detect rare cancer cells in blood and bone marrow. Multiple markers; each identified by a separate color of immunofluorescence (yellow and two shades of red), are used to reliably identify the cancer cells. Blood or bone marrow cells, which are not of interes...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1995-01, Vol.92 (2), p.537-541
Hauptverfasser:	Gross, H J, Verwer, B, Houck, D, Hoffman, R A, Recktenwald, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Biomarkers, Tumor Breast Neoplasms - pathology Carcinoma - pathology Diagnosis, Computer-Assisted - methods Flow Cytometry - methods Fluorescent Antibody Technique Humans Leukocytes, Mononuclear - cytology Neoplasm Metastasis Neoplastic Cells, Circulating - pathology Sensitivity and Specificity Tumor Cells, Cultured
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