Inhibition of Cardiac Sarcolemmal Sodium-Calcium Exchanger by Glycerophosphoinositol 4-Phosphate and Glycerophosphoinositol 4-5-Bisphosphate
The enrichment in phosphatidylinositol 4-phosphate and phosphatidylinositoI 4-5-bisphosphate of cardiac sarcolemmal vesicles stimulate Na+/Ca2+ exchange activity. On the contrary the deacylation products of polyphosphoinositides are powerful inhibitors of Na+/Ca2+ exchange: half maximal inhibition o...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1995-01, Vol.206 (2), p.674-680 |
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| container_end_page | 680 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Luciani, S. Antolini, M. Bova, S. Cargnelli, G. Cusinato, F. Debetto, P. Trevisi, L. Varotto, R. |
| description | The enrichment in phosphatidylinositol 4-phosphate and phosphatidylinositoI 4-5-bisphosphate of cardiac sarcolemmal vesicles stimulate Na+/Ca2+ exchange activity. On the contrary the deacylation products of polyphosphoinositides are powerful inhibitors of Na+/Ca2+ exchange: half maximal inhibition of 1.6 and 2.1 μM have been observed for glycerophosphoinositol 4-phosphate and glycerophosphoinositol 4-5-bisphosphate, respectively. The data indicate a bidirectional regulation of Na+/Ca2+ exchanger and suggest that phosphorylated glycerophosphoinositoIs can be regarded as novel signal transducers of intracellular Ca2+ regulation in heart cell. |
| doi_str_mv | 10.1006/bbrc.1995.1095 |
| format | Article |
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The data indicate a bidirectional regulation of Na+/Ca2+ exchanger and suggest that phosphorylated glycerophosphoinositoIs can be regarded as novel signal transducers of intracellular Ca2+ regulation in heart cell.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1006/bbrc.1995.1095</identifier><identifier>PMID: 7826386</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Calcium - metabolism ; Carrier Proteins - antagonists & inhibitors ; Cattle ; Heart Ventricles ; Inositol Phosphates - isolation & purification ; Inositol Phosphates - metabolism ; Inositol Phosphates - pharmacology ; Kinetics ; Myocardium - metabolism ; Phosphatidylinositol Phosphates - pharmacology ; Sarcolemma - metabolism ; Sodium - metabolism ; Sodium-Calcium Exchanger</subject><ispartof>Biochemical and biophysical research communications, 1995-01, Vol.206 (2), p.674-680</ispartof><rights>1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-2a6a595a24c9f8721459390e85a6c1ea265aa32e3fff71570e4c7adc80b44ba3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/bbrc.1995.1095$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7826386$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luciani, S.</creatorcontrib><creatorcontrib>Antolini, M.</creatorcontrib><creatorcontrib>Bova, S.</creatorcontrib><creatorcontrib>Cargnelli, G.</creatorcontrib><creatorcontrib>Cusinato, F.</creatorcontrib><creatorcontrib>Debetto, P.</creatorcontrib><creatorcontrib>Trevisi, L.</creatorcontrib><creatorcontrib>Varotto, R.</creatorcontrib><title>Inhibition of Cardiac Sarcolemmal Sodium-Calcium Exchanger by Glycerophosphoinositol 4-Phosphate and Glycerophosphoinositol 4-5-Bisphosphate</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>The enrichment in phosphatidylinositol 4-phosphate and phosphatidylinositoI 4-5-bisphosphate of cardiac sarcolemmal vesicles stimulate Na+/Ca2+ exchange activity. 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The data indicate a bidirectional regulation of Na+/Ca2+ exchanger and suggest that phosphorylated glycerophosphoinositoIs can be regarded as novel signal transducers of intracellular Ca2+ regulation in heart cell.</description><subject>Animals</subject><subject>Calcium - metabolism</subject><subject>Carrier Proteins - antagonists & inhibitors</subject><subject>Cattle</subject><subject>Heart Ventricles</subject><subject>Inositol Phosphates - isolation & purification</subject><subject>Inositol Phosphates - metabolism</subject><subject>Inositol Phosphates - pharmacology</subject><subject>Kinetics</subject><subject>Myocardium - metabolism</subject><subject>Phosphatidylinositol Phosphates - pharmacology</subject><subject>Sarcolemma - metabolism</subject><subject>Sodium - metabolism</subject><subject>Sodium-Calcium Exchanger</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFO4zAURS3ECAozW3ZIXrFLx47tJF5C1SlISCCVxeysF-eFGiVxsVNE_2E-GpeW2bGwrux3fKV3CLngbMoZK37XdbBTrrVKV62OyCQFy3LO5DGZsERkueZ_T8lZjC-McS4LfUJOyiovRFVMyL-7YeVqNzo_UN_SGYTGgaVLCNZ32PfQ0aVv3KbPZtDZlHT-blcwPGOg9ZYuuq3F4NcrH9Nxg49u9B2V2ePnC4xIYWi-x1R24-L6i_1JfrTQRfx1yHPy9Gf-NLvN7h8Wd7Pr-8wKoccshwKUVpBLq9uqzLlUWmiGlYLCcoS8UAAiR9G2bclVyVDaEhpbsVrKGsQ5udrXroN_3WAcTe-ixa6DAf0mmrLkvJJCJHC6B23wMQZszTq4HsLWcGZ29s3OvtnZNzv76cPloXlT99j8xw-607zazzFt9-YwmGgdDhYbF9COpvHuu-oP83WW-A</recordid><startdate>19950117</startdate><enddate>19950117</enddate><creator>Luciani, S.</creator><creator>Antolini, M.</creator><creator>Bova, S.</creator><creator>Cargnelli, G.</creator><creator>Cusinato, F.</creator><creator>Debetto, P.</creator><creator>Trevisi, L.</creator><creator>Varotto, R.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950117</creationdate><title>Inhibition of Cardiac Sarcolemmal Sodium-Calcium Exchanger by Glycerophosphoinositol 4-Phosphate and Glycerophosphoinositol 4-5-Bisphosphate</title><author>Luciani, S. ; Antolini, M. ; Bova, S. ; Cargnelli, G. ; Cusinato, F. ; Debetto, P. ; Trevisi, L. ; Varotto, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-2a6a595a24c9f8721459390e85a6c1ea265aa32e3fff71570e4c7adc80b44ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Calcium - metabolism</topic><topic>Carrier Proteins - antagonists & inhibitors</topic><topic>Cattle</topic><topic>Heart Ventricles</topic><topic>Inositol Phosphates - isolation & purification</topic><topic>Inositol Phosphates - metabolism</topic><topic>Inositol Phosphates - pharmacology</topic><topic>Kinetics</topic><topic>Myocardium - metabolism</topic><topic>Phosphatidylinositol Phosphates - pharmacology</topic><topic>Sarcolemma - metabolism</topic><topic>Sodium - metabolism</topic><topic>Sodium-Calcium Exchanger</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luciani, S.</creatorcontrib><creatorcontrib>Antolini, M.</creatorcontrib><creatorcontrib>Bova, S.</creatorcontrib><creatorcontrib>Cargnelli, G.</creatorcontrib><creatorcontrib>Cusinato, F.</creatorcontrib><creatorcontrib>Debetto, P.</creatorcontrib><creatorcontrib>Trevisi, L.</creatorcontrib><creatorcontrib>Varotto, R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luciani, S.</au><au>Antolini, M.</au><au>Bova, S.</au><au>Cargnelli, G.</au><au>Cusinato, F.</au><au>Debetto, P.</au><au>Trevisi, L.</au><au>Varotto, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of Cardiac Sarcolemmal Sodium-Calcium Exchanger by Glycerophosphoinositol 4-Phosphate and Glycerophosphoinositol 4-5-Bisphosphate</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1995-01-17</date><risdate>1995</risdate><volume>206</volume><issue>2</issue><spage>674</spage><epage>680</epage><pages>674-680</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>The enrichment in phosphatidylinositol 4-phosphate and phosphatidylinositoI 4-5-bisphosphate of cardiac sarcolemmal vesicles stimulate Na+/Ca2+ exchange activity. On the contrary the deacylation products of polyphosphoinositides are powerful inhibitors of Na+/Ca2+ exchange: half maximal inhibition of 1.6 and 2.1 μM have been observed for glycerophosphoinositol 4-phosphate and glycerophosphoinositol 4-5-bisphosphate, respectively. The data indicate a bidirectional regulation of Na+/Ca2+ exchanger and suggest that phosphorylated glycerophosphoinositoIs can be regarded as novel signal transducers of intracellular Ca2+ regulation in heart cell.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7826386</pmid><doi>10.1006/bbrc.1995.1095</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Biochemical and biophysical research communications, 1995-01, Vol.206 (2), p.674-680 |
| issn | 0006-291X 1090-2104 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Calcium - metabolism Carrier Proteins - antagonists & inhibitors Cattle Heart Ventricles Inositol Phosphates - isolation & purification Inositol Phosphates - metabolism Inositol Phosphates - pharmacology Kinetics Myocardium - metabolism Phosphatidylinositol Phosphates - pharmacology Sarcolemma - metabolism Sodium - metabolism Sodium-Calcium Exchanger |
| title | Inhibition of Cardiac Sarcolemmal Sodium-Calcium Exchanger by Glycerophosphoinositol 4-Phosphate and Glycerophosphoinositol 4-5-Bisphosphate |
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