Advantages and disadvantages of fludrocortisone or saline load in preventing post-spaceflight orthostatic hypotension

The purpose of this study was to compare the effectiveness of saline load to fludrocortisone (florinef) as countermeasures for reduced plasma volume and orthostatic intolerance after spaceflight. Eleven males (ages 30–50 yr) underwent a 3-day ambulatory baseline period followed by 7 days of 6° head-...

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Veröffentlicht in:	Acta astronautica 1994, Vol.33, p.259-266
Hauptverfasser:	Vernikos, Joan, Convertino, Victor A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Baroreflex - physiology Bed Rest - adverse effects Fludrocortisone - administration & dosage Fludrocortisone - therapeutic use Head-Down Tilt - adverse effects Hemodynamics Humans Hypotension, Orthostatic - etiology Hypotension, Orthostatic - physiopathology Hypotension, Orthostatic - prevention & control Male Middle Aged Norepinephrine - blood Plasma Volume Potassium - urine Sodium - urine Sodium Chloride - administration & dosage Sodium Chloride - therapeutic use Space life sciences Vascular Resistance - drug effects Vascular Resistance - physiology Weightlessness Countermeasures Weightlessness Simulation
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