Pharmacokinetics Do Not Explain the Absence of an Anesthetic Effect of Perfluoropropane or Perfluoropentane

In conflict with the prediction of the Meyer-Overton hypothesis, perfluoropropane (C,F,) and perfluoropentane (C5F12) have no anesthetic effect in rats. To test whether this resulted from a failure of the inspired drugs to reach the brain, we determined the increase in partial pressures of C,F, and...

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Veröffentlicht in:	Anesthesia and analgesia 1994-08, Vol.79 (2), p.234-237
Hauptverfasser:	Chortkoff, Ben S., Laster, Michael J., Koblin, Donald D., Taheri, Shahram, Eger, Edmond I, Halsey, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia, Inhalation Anesthetics. Neuromuscular blocking agents Animals Biological and medical sciences Blood-Brain Barrier - drug effects Brain - metabolism Fluorocarbons - pharmacokinetics Fluorocarbons - pharmacology Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Specific Pathogen-Free Organisms
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